BRPI0406618A - Compostos possuindo atividade inibitória da propil oligopeptidase - Google Patents
Compostos possuindo atividade inibitória da propil oligopeptidaseInfo
- Publication number
- BRPI0406618A BRPI0406618A BR0406618-9A BRPI0406618A BRPI0406618A BR PI0406618 A BRPI0406618 A BR PI0406618A BR PI0406618 A BRPI0406618 A BR PI0406618A BR PI0406618 A BRPI0406618 A BR PI0406618A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- inhibitory activity
- propyl
- formula
- propyl oligopeptidase
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 108010032563 oligopeptidase Proteins 0.000 title abstract 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title abstract 4
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
"COMPOSTOS POSSUINDO ATIVIDADE INIBITóRIA DA PROPIL OLIGOPEPTIDASE". A invenção fornece um composto de fórmula (I), onde na fórmula X, R~ 1~, R~ 2~ e R~ 3~ são conforme definido na reivindicação 1, ou um sal farmaceuticamente aceitável ou seu éster, útil como um inibidor da propil oligopeptidase. Os compostos de fórmula (I) podem ser utilizados para o tratamento de doenças ou condições onde os inibidores da propil oligopeptidase são indicados como sendo eficazes, por exemplo, para o tratamento de doenças neuro-degenerativas, tais como doença de Alzheimer e demência senil.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20030014A FI20030014A0 (fi) | 2003-01-03 | 2003-01-03 | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä |
| PCT/FI2004/000001 WO2004060862A2 (en) | 2003-01-03 | 2004-01-02 | Compounds having prolyl oligopeptidase inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0406618A true BRPI0406618A (pt) | 2005-12-06 |
Family
ID=8565256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0406618-9A BRPI0406618A (pt) | 2003-01-03 | 2004-01-02 | Compostos possuindo atividade inibitória da propil oligopeptidase |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060229254A1 (pt) |
| EP (1) | EP1581489A2 (pt) |
| JP (1) | JP2006516557A (pt) |
| KR (1) | KR20060027789A (pt) |
| CN (1) | CN1747930A (pt) |
| AU (1) | AU2004203788A1 (pt) |
| BR (1) | BRPI0406618A (pt) |
| CA (1) | CA2511856A1 (pt) |
| EA (1) | EA010022B1 (pt) |
| FI (1) | FI20030014A0 (pt) |
| HR (1) | HRP20050693A2 (pt) |
| IS (1) | IS7963A (pt) |
| MX (1) | MXPA05007262A (pt) |
| NO (1) | NO20053726L (pt) |
| PL (1) | PL378329A1 (pt) |
| RS (1) | RS20050514A (pt) |
| WO (1) | WO2004060862A2 (pt) |
| ZA (1) | ZA200505183B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2513053T3 (pt) | 2009-12-18 | 2018-03-03 | ||
| EP2730571A1 (en) | 2012-11-12 | 2014-05-14 | Universitat De Barcelona | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives |
| CN105916500A (zh) * | 2013-11-27 | 2016-08-31 | 欧洲筛选有限公司 | 用于治疗炎性疾病的化合物、药物组合物和方法 |
| KR101913506B1 (ko) * | 2017-07-18 | 2018-10-30 | 경상대학교산학협력단 | 프롤릴 올리고펩티다아제 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물 |
| HUE068953T2 (hu) | 2020-07-07 | 2025-02-28 | Accure Therapeutics S L | 1-[1-(4-benziloxi-3,5-difluor-benzoil)-4-fluor-pirrolidin-2-karbonil]-pirrolidin-2-karbonitril |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4483991A (en) * | 1983-01-17 | 1984-11-20 | American Home Products Corporation | Hypotensive agents |
| US4873342A (en) * | 1985-04-16 | 1989-10-10 | Suntory Limited | Dipeptide derivative and synthesis and use thereof |
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| JPH0696563B2 (ja) * | 1986-02-04 | 1994-11-30 | サントリー株式会社 | アシルアミノ酸誘導体、その製法並びに用途 |
| CA2084412C (en) * | 1990-06-04 | 2000-05-09 | W. Stephen Faraci | Pyrrolidine and thiazolidine amides |
| WO1991018877A1 (en) * | 1990-06-07 | 1991-12-12 | Zeria Pharmaceutical Co., Ltd. | Novel arylalkanoylamine derivative and drug containing the same |
| ES2182203T3 (es) * | 1997-10-31 | 2003-03-01 | Hoffmann La Roche | Derivados de d-prolina. |
-
2003
- 2003-01-03 FI FI20030014A patent/FI20030014A0/fi unknown
-
2004
- 2004-01-02 US US10/541,387 patent/US20060229254A1/en not_active Abandoned
- 2004-01-02 EA EA200501083A patent/EA010022B1/ru not_active IP Right Cessation
- 2004-01-02 AU AU2004203788A patent/AU2004203788A1/en not_active Abandoned
- 2004-01-02 CN CNA2004800034680A patent/CN1747930A/zh active Pending
- 2004-01-02 KR KR1020057012201A patent/KR20060027789A/ko not_active Withdrawn
- 2004-01-02 CA CA002511856A patent/CA2511856A1/en not_active Abandoned
- 2004-01-02 WO PCT/FI2004/000001 patent/WO2004060862A2/en not_active Ceased
- 2004-01-02 BR BR0406618-9A patent/BRPI0406618A/pt not_active IP Right Cessation
- 2004-01-02 EP EP04700047A patent/EP1581489A2/en not_active Withdrawn
- 2004-01-02 RS YUP-2005/0514A patent/RS20050514A/sr unknown
- 2004-01-02 PL PL378329A patent/PL378329A1/pl unknown
- 2004-01-02 MX MXPA05007262A patent/MXPA05007262A/es not_active Application Discontinuation
- 2004-01-02 HR HR20050693A patent/HRP20050693A2/hr not_active Application Discontinuation
- 2004-01-02 JP JP2006500146A patent/JP2006516557A/ja active Pending
-
2005
- 2005-06-27 ZA ZA200505183A patent/ZA200505183B/en unknown
- 2005-07-28 IS IS7963A patent/IS7963A/is unknown
- 2005-08-03 NO NO20053726A patent/NO20053726L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2511856A1 (en) | 2004-07-22 |
| NO20053726D0 (no) | 2005-08-03 |
| EA010022B1 (ru) | 2008-06-30 |
| RS20050514A (sr) | 2007-12-31 |
| ZA200505183B (en) | 2006-04-26 |
| AU2004203788A1 (en) | 2004-07-22 |
| US20060229254A1 (en) | 2006-10-12 |
| PL378329A1 (pl) | 2006-03-20 |
| WO2004060862A3 (en) | 2004-11-25 |
| JP2006516557A (ja) | 2006-07-06 |
| FI20030014A0 (fi) | 2003-01-03 |
| HRP20050693A2 (en) | 2005-10-31 |
| CN1747930A (zh) | 2006-03-15 |
| IS7963A (is) | 2005-07-28 |
| WO2004060862A2 (en) | 2004-07-22 |
| NO20053726L (no) | 2005-09-28 |
| KR20060027789A (ko) | 2006-03-28 |
| EP1581489A2 (en) | 2005-10-05 |
| EA200501083A1 (ru) | 2006-02-24 |
| MXPA05007262A (es) | 2005-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |