PL378329A1 - Związki o aktywności hamującej wobec oligopeptydazy prolilowej - Google Patents

Związki o aktywności hamującej wobec oligopeptydazy prolilowej

Info

Publication number
PL378329A1
PL378329A1 PL378329A PL37832904A PL378329A1 PL 378329 A1 PL378329 A1 PL 378329A1 PL 378329 A PL378329 A PL 378329A PL 37832904 A PL37832904 A PL 37832904A PL 378329 A1 PL378329 A1 PL 378329A1
Authority
PL
Poland
Prior art keywords
compounds
inhibitory activity
prolyl oligopeptidase
oligopeptidase inhibitory
prolyl
Prior art date
Application number
PL378329A
Other languages
English (en)
Inventor
Jukka Gynther
Erik Wallen
Elina Jarho
Pekka Männistö
Markus Forsberg
Antti Poso
Johannes Christiaans
Jarkko Venäläinen
Jouko Vepsäläinen
Taija Saarinen
Tomi Järvinen
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of PL378329A1 publication Critical patent/PL378329A1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PL378329A 2003-01-03 2004-01-02 Związki o aktywności hamującej wobec oligopeptydazy prolilowej PL378329A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20030014A FI20030014A0 (fi) 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä

Publications (1)

Publication Number Publication Date
PL378329A1 true PL378329A1 (pl) 2006-03-20

Family

ID=8565256

Family Applications (1)

Application Number Title Priority Date Filing Date
PL378329A PL378329A1 (pl) 2003-01-03 2004-01-02 Związki o aktywności hamującej wobec oligopeptydazy prolilowej

Country Status (18)

Country Link
US (1) US20060229254A1 (pl)
EP (1) EP1581489A2 (pl)
JP (1) JP2006516557A (pl)
KR (1) KR20060027789A (pl)
CN (1) CN1747930A (pl)
AU (1) AU2004203788A1 (pl)
BR (1) BRPI0406618A (pl)
CA (1) CA2511856A1 (pl)
EA (1) EA010022B1 (pl)
FI (1) FI20030014A0 (pl)
HR (1) HRP20050693A2 (pl)
IS (1) IS7963A (pl)
MX (1) MXPA05007262A (pl)
NO (1) NO20053726L (pl)
PL (1) PL378329A1 (pl)
RS (1) RS20050514A (pl)
WO (1) WO2004060862A2 (pl)
ZA (1) ZA200505183B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102812003B (zh) 2009-12-18 2015-01-21 欧洲筛选有限公司 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
CN105916500A (zh) * 2013-11-27 2016-08-31 欧洲筛选有限公司 用于治疗炎性疾病的化合物、药物组合物和方法
KR101913506B1 (ko) * 2017-07-18 2018-10-30 경상대학교산학협력단 프롤릴 올리고펩티다아제 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물
KR20230035604A (ko) 2020-07-07 2023-03-14 어큐어 테라퓨틱스, 에스.엘. 1-[1-(4-벤질옥시-3,5-디플루오로-벤조일)-4-플루오로-피롤리딘-2-카보닐]-피롤리딘-2-카보니트릴

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
CA1309805C (en) * 1985-04-16 1992-11-03 Naoki Higuchi Dipeptide derivative and synthesis and use thereof
JPH0696563B2 (ja) * 1986-02-04 1994-11-30 サントリー株式会社 アシルアミノ酸誘導体、その製法並びに用途
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
FI925500A7 (fi) * 1990-06-04 1992-12-03 Pfizer Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja
AU643300B2 (en) * 1990-06-07 1993-11-11 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
DK0915088T3 (da) * 1997-10-31 2003-01-27 Hoffmann La Roche D-prolinderivater

Also Published As

Publication number Publication date
CN1747930A (zh) 2006-03-15
KR20060027789A (ko) 2006-03-28
FI20030014A0 (fi) 2003-01-03
WO2004060862A3 (en) 2004-11-25
NO20053726L (no) 2005-09-28
MXPA05007262A (es) 2005-09-08
BRPI0406618A (pt) 2005-12-06
AU2004203788A1 (en) 2004-07-22
EP1581489A2 (en) 2005-10-05
HRP20050693A2 (en) 2005-10-31
WO2004060862A2 (en) 2004-07-22
EA200501083A1 (ru) 2006-02-24
CA2511856A1 (en) 2004-07-22
NO20053726D0 (no) 2005-08-03
IS7963A (is) 2005-07-28
EA010022B1 (ru) 2008-06-30
JP2006516557A (ja) 2006-07-06
RS20050514A (sr) 2007-12-31
ZA200505183B (en) 2006-04-26
US20060229254A1 (en) 2006-10-12

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Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)