PL378329A1 - Związki o aktywności hamującej wobec oligopeptydazy prolilowej - Google Patents
Związki o aktywności hamującej wobec oligopeptydazy prolilowejInfo
- Publication number
- PL378329A1 PL378329A1 PL378329A PL37832904A PL378329A1 PL 378329 A1 PL378329 A1 PL 378329A1 PL 378329 A PL378329 A PL 378329A PL 37832904 A PL37832904 A PL 37832904A PL 378329 A1 PL378329 A1 PL 378329A1
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- inhibitory activity
- prolyl oligopeptidase
- oligopeptidase inhibitory
- prolyl
- Prior art date
Links
- 101001095266 Homo sapiens Prolyl endopeptidase Proteins 0.000 title 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20030014A FI20030014A0 (fi) | 2003-01-03 | 2003-01-03 | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL378329A1 true PL378329A1 (pl) | 2006-03-20 |
Family
ID=8565256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL378329A PL378329A1 (pl) | 2003-01-03 | 2004-01-02 | Związki o aktywności hamującej wobec oligopeptydazy prolilowej |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060229254A1 (pl) |
| EP (1) | EP1581489A2 (pl) |
| JP (1) | JP2006516557A (pl) |
| KR (1) | KR20060027789A (pl) |
| CN (1) | CN1747930A (pl) |
| AU (1) | AU2004203788A1 (pl) |
| BR (1) | BRPI0406618A (pl) |
| CA (1) | CA2511856A1 (pl) |
| EA (1) | EA010022B1 (pl) |
| FI (1) | FI20030014A0 (pl) |
| HR (1) | HRP20050693A2 (pl) |
| IS (1) | IS7963A (pl) |
| MX (1) | MXPA05007262A (pl) |
| NO (1) | NO20053726L (pl) |
| PL (1) | PL378329A1 (pl) |
| RS (1) | RS20050514A (pl) |
| WO (1) | WO2004060862A2 (pl) |
| ZA (1) | ZA200505183B (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102812003B (zh) | 2009-12-18 | 2015-01-21 | 欧洲筛选有限公司 | 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法 |
| EP2730571A1 (en) | 2012-11-12 | 2014-05-14 | Universitat De Barcelona | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives |
| CN105916500A (zh) * | 2013-11-27 | 2016-08-31 | 欧洲筛选有限公司 | 用于治疗炎性疾病的化合物、药物组合物和方法 |
| KR101913506B1 (ko) * | 2017-07-18 | 2018-10-30 | 경상대학교산학협력단 | 프롤릴 올리고펩티다아제 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물 |
| KR20230035604A (ko) | 2020-07-07 | 2023-03-14 | 어큐어 테라퓨틱스, 에스.엘. | 1-[1-(4-벤질옥시-3,5-디플루오로-벤조일)-4-플루오로-피롤리딘-2-카보닐]-피롤리딘-2-카보니트릴 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4483991A (en) * | 1983-01-17 | 1984-11-20 | American Home Products Corporation | Hypotensive agents |
| CA1309805C (en) * | 1985-04-16 | 1992-11-03 | Naoki Higuchi | Dipeptide derivative and synthesis and use thereof |
| JPH0696563B2 (ja) * | 1986-02-04 | 1994-11-30 | サントリー株式会社 | アシルアミノ酸誘導体、その製法並びに用途 |
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| FI925500A7 (fi) * | 1990-06-04 | 1992-12-03 | Pfizer | Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja |
| AU643300B2 (en) * | 1990-06-07 | 1993-11-11 | Zeria Pharmaceutical Co., Ltd. | Novel arylalkanoylamine derivative and drug containing the same |
| DK0915088T3 (da) * | 1997-10-31 | 2003-01-27 | Hoffmann La Roche | D-prolinderivater |
-
2003
- 2003-01-03 FI FI20030014A patent/FI20030014A0/fi unknown
-
2004
- 2004-01-02 CN CNA2004800034680A patent/CN1747930A/zh active Pending
- 2004-01-02 JP JP2006500146A patent/JP2006516557A/ja active Pending
- 2004-01-02 EP EP04700047A patent/EP1581489A2/en not_active Withdrawn
- 2004-01-02 CA CA002511856A patent/CA2511856A1/en not_active Abandoned
- 2004-01-02 EA EA200501083A patent/EA010022B1/ru not_active IP Right Cessation
- 2004-01-02 MX MXPA05007262A patent/MXPA05007262A/es not_active Application Discontinuation
- 2004-01-02 KR KR1020057012201A patent/KR20060027789A/ko not_active Withdrawn
- 2004-01-02 US US10/541,387 patent/US20060229254A1/en not_active Abandoned
- 2004-01-02 HR HR20050693A patent/HRP20050693A2/hr not_active Application Discontinuation
- 2004-01-02 AU AU2004203788A patent/AU2004203788A1/en not_active Abandoned
- 2004-01-02 WO PCT/FI2004/000001 patent/WO2004060862A2/en not_active Ceased
- 2004-01-02 BR BR0406618-9A patent/BRPI0406618A/pt not_active IP Right Cessation
- 2004-01-02 RS YUP-2005/0514A patent/RS20050514A/sr unknown
- 2004-01-02 PL PL378329A patent/PL378329A1/pl unknown
-
2005
- 2005-06-27 ZA ZA200505183A patent/ZA200505183B/en unknown
- 2005-07-28 IS IS7963A patent/IS7963A/is unknown
- 2005-08-03 NO NO20053726A patent/NO20053726L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1747930A (zh) | 2006-03-15 |
| KR20060027789A (ko) | 2006-03-28 |
| FI20030014A0 (fi) | 2003-01-03 |
| WO2004060862A3 (en) | 2004-11-25 |
| NO20053726L (no) | 2005-09-28 |
| MXPA05007262A (es) | 2005-09-08 |
| BRPI0406618A (pt) | 2005-12-06 |
| AU2004203788A1 (en) | 2004-07-22 |
| EP1581489A2 (en) | 2005-10-05 |
| HRP20050693A2 (en) | 2005-10-31 |
| WO2004060862A2 (en) | 2004-07-22 |
| EA200501083A1 (ru) | 2006-02-24 |
| CA2511856A1 (en) | 2004-07-22 |
| NO20053726D0 (no) | 2005-08-03 |
| IS7963A (is) | 2005-07-28 |
| EA010022B1 (ru) | 2008-06-30 |
| JP2006516557A (ja) | 2006-07-06 |
| RS20050514A (sr) | 2007-12-31 |
| ZA200505183B (en) | 2006-04-26 |
| US20060229254A1 (en) | 2006-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DISC | Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications) |