AR048033A1 - Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion - Google Patents

Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion

Info

Publication number
AR048033A1
AR048033A1 ARP050100929A ARP050100929A AR048033A1 AR 048033 A1 AR048033 A1 AR 048033A1 AR P050100929 A ARP050100929 A AR P050100929A AR P050100929 A ARP050100929 A AR P050100929A AR 048033 A1 AR048033 A1 AR 048033A1
Authority
AR
Argentina
Prior art keywords
weight
pharmaceutical composition
pharmaceutical
amount
present
Prior art date
Application number
ARP050100929A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR048033A1 publication Critical patent/AR048033A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)

Abstract

Una composicion farmacéutica para moldear componentes, que comprende copolímero de poli(met)acrilato (Eudragit RL 100 o RS 100) presentes en una cantidad de aproximadamente 10 a aproximadamente 80% en peso/peso; al menos una excipiente modificador de la disolucion, presente en una cantidad total de aproximadamente 20% a aproximadamente 70% en peso/peso; un lubricante presente en una cantidad de aproximadamente 5% a aproximadamente 25% en peso/peso; y opcionalmente un tensioactivo presente en una cantidad de 0 a aproximadamente 10%, un plastificante presente en una cantidad de 0 a aproximadamente 10% en peso/peso, y un agente de polimerizacion presente en una cantidad de 0 a aproximadamente 10% en peso/peso. Cubierta, conector o espaciador de cápsula moldeado por inyeccion, que tiene una composicion como se define anteriormente. Forma de dosificacion farmacéutica de multicomponentes moldeadas a partir de la composicion farmacéutica descripta.
ARP050100929A 2004-03-12 2005-03-10 Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion AR048033A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55249904P 2004-03-12 2004-03-12

Publications (1)

Publication Number Publication Date
AR048033A1 true AR048033A1 (es) 2006-03-22

Family

ID=34993424

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100929A AR048033A1 (es) 2004-03-12 2005-03-10 Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion

Country Status (17)

Country Link
US (3) US8147871B2 (es)
EP (1) EP1729744A4 (es)
JP (2) JP2007528901A (es)
KR (3) KR20130010511A (es)
CN (1) CN1953739B (es)
AR (1) AR048033A1 (es)
AU (1) AU2005222612C1 (es)
BR (1) BRPI0508342A (es)
CA (1) CA2559227A1 (es)
IL (1) IL177566A (es)
MA (1) MA28489B1 (es)
NO (1) NO20064570L (es)
NZ (1) NZ549264A (es)
PE (1) PE20060003A1 (es)
RU (2) RU2447885C2 (es)
TW (2) TW201240679A (es)
WO (1) WO2005089726A1 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1204410B1 (en) * 1999-07-30 2012-09-12 Capsugel Belgium NV Multi-component pharmaceutical dosage form
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US7842308B2 (en) * 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
TWI336260B (en) * 2002-07-25 2011-01-21 Glaxo Group Ltd Dosage form suitable for retaining drug substance
ES2665464T3 (es) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin costuras
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
EP1802287A2 (en) * 2004-09-27 2007-07-04 Sigmoid Biotechnologies Limited Minicapsule formulations
US8022032B2 (en) * 2004-11-19 2011-09-20 Smithkline Beecham Corporation Method for customized dispensing of variable dose drug combination products for individualizing of therapies
BRPI0520830A2 (pt) * 2005-12-30 2009-05-19 Accu Break Technologies Inc forma de dosagem farmacêutica sólida, método de subdividir uma forma de dosagem farmacêutica sólida, método de administração de uma parte de uma subunidade ativa de uma forma de dosagem farmacêutica sólida, método de administração de um ingrediente farmacêutico ativo que está presente dentro de uma subunidade ativa de uma forma de dosagem farmacêutica sólida e método de produção de uma forma de dosagem farmacêutica sólida
ES2459018T3 (es) 2006-02-09 2014-05-07 Alba Therapeutics Corporation Formulaciones de efectores de la unión estrecha
CN101460191A (zh) * 2006-06-02 2009-06-17 特瓦制药工业有限公司 包含湿敏性药物的稳定制剂及其制备方法
US8034776B2 (en) 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
ES2393814T3 (es) 2007-04-04 2012-12-28 Sigmoid Pharma Limited Una composición farmacéutica oral
CA2685118C (en) * 2007-04-26 2016-11-01 Sigmoid Pharma Limited Manufacture of multiple minicapsules
CA2685397C (en) * 2007-04-27 2016-07-26 Endo Pharmaceuticals Solutions Inc. Implant device release agents and methods of using same
WO2008132712A2 (en) * 2007-05-01 2008-11-06 Sigmoid Pharma Limited Combination pharmaceutical compositions
EP2209456B1 (en) * 2007-10-15 2013-03-06 Capsugel Belgium NV Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms
CN101827573A (zh) 2007-10-15 2010-09-08 葛兰素集团有限公司 已装填的连接件的制造装置和方法
US8454992B2 (en) * 2007-10-15 2013-06-04 Capsugel Belgium Nv Paneled capsule shells for release of pharmaceutical compositions
EP2219624A2 (en) 2007-11-08 2010-08-25 Glaxo Group Limited Pharmaceutical formulations
BRPI0821735A2 (pt) * 2007-12-21 2015-06-16 Mcneil Ppc Inc Fabricação de tablete
AU2009256572A1 (en) * 2008-06-13 2009-12-17 Capsugel Belgium Nv Hydroxypropyl cellulose capsule shell
IT1393245B1 (it) * 2008-07-24 2012-04-12 Universita' Degli Studi Di Milano Forme farmaceutiche per il rilascio tempo-specifico di farmaci
US8900634B2 (en) * 2008-11-03 2014-12-02 Nal Pharmaceuticals, Ltd. Diethylstilbestrol dosage form and methods of treatment using thereof
CN102369001A (zh) 2009-01-09 2012-03-07 前进制药公司 包含溶蚀骨架中的一种或多种富马酸酯的药物制剂
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
CN102573802A (zh) 2009-08-12 2012-07-11 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
MX339408B (es) * 2010-03-09 2016-05-24 Alkermes Pharma Ireland Ltd Composiciones farmaceuticas entericas resistentes al alcohol.
EP3354335A1 (en) * 2010-10-26 2018-08-01 Capsugel Belgium NV Bulk enteric capsule shells
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
IN2014CN02610A (es) 2011-10-12 2015-08-07 Dow Global Technologies Llc
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
US20160256399A1 (en) 2013-11-04 2016-09-08 Capsugel Belgium Nv Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
TWI535784B (zh) 2014-08-26 2016-06-01 財團法人工業技術研究院 剪切增稠配方、及包含其之複合材料
JP6716582B2 (ja) 2014-11-07 2020-07-01 サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ シクロスポリンを含む組成物
US20160331689A1 (en) 2015-05-12 2016-11-17 SE Tylose USA, Inc. Aqueous enteric coating composition
US11576859B2 (en) * 2015-10-23 2023-02-14 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
WO2017100367A1 (en) 2015-12-08 2017-06-15 Lyndra, Inc. Geometric configurations for gastric residence systems
CN109310639A (zh) 2016-05-27 2019-02-05 林德拉有限公司 用于胃驻留系统的材料结构
JP2019532947A (ja) 2016-09-30 2019-11-14 リンドラ，インコーポレイティド アダマンタン系薬物の持続的送達のための胃内滞留システム
CA3066658A1 (en) 2017-06-09 2018-12-13 Lyndra, Inc. Gastric residence systems with release rate-modulating films
WO2019082171A1 (en) * 2017-10-27 2019-05-02 Alvit Pharma ORAL CANNABINOID COMPOSITIONS HAVING ENHANCED BIOAVAILABILITY
CN112499717B (zh) * 2020-12-10 2021-10-22 江南大学 一种聚合物包含膜在染料吸附中的应用

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3186910A (en) * 1962-03-08 1965-06-01 Jacob A Glassman Method for producing peroral capsules
US3228789A (en) * 1962-10-22 1966-01-11 Jacob A Glassman Peroral capsules and tablets and the method for making same
US3314809A (en) * 1963-02-08 1967-04-18 Hercules Inc Process of making thermoplastic shaped articles from hydroxypropyl cellulose having an m.s. of at least 2
US3394983A (en) * 1963-06-14 1968-07-30 American Cyanamid Co Dip-dyeing capsules
FR1454013A (fr) 1965-08-18 1966-07-22 Pluripharm Mode de présentation de deux médicaments associés
US3399803A (en) 1966-10-11 1968-09-03 Parke Davis & Co Self-locking medicament capsule
US3779942A (en) 1970-12-04 1973-12-18 Minnesota Mining & Mfg Capsules and process for forming capsules
US3723312A (en) * 1970-12-18 1973-03-27 Ppg Industries Inc Combined stain retardant and separator interleaving material for glass sheets
DE2428397C3 (de) 1974-06-12 1978-05-18 Scherer Hartkapsel Gmbh, 6930 Eberbach Zweiteilige Kapsel aus Hartgelatine
NL7610038A (en) 1976-09-09 1978-03-13 Tapanahony N V Multichambered capsule for therapeutically active substances - has chambers of different solubility with contents differing quantitatively and qualitatively
DE2722822C2 (de) * 1977-05-20 1984-11-08 Capsugel AG, Basel Verfahren zum Herstellen einer zum Aufnehmen eines viskosen Stoffes, insbesondere eines flüssigen Arzneimittels, geeigneten Steckkapsel
US4250097A (en) * 1978-03-08 1981-02-10 Syntex (U.S.A.) Inc. Compositions for and a method of preventing diabetic complications
FI63335B (fi) 1979-02-02 1983-02-28 Orion Yhtymae Oy Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne
US4281763A (en) * 1979-10-31 1981-08-04 Pace Joseph A Two-piece hardshell, soluble and digestible liquid containing gelatin capsule
USRE34390E (en) 1980-12-31 1993-09-28 Nicolet Instrument Corporation Apparatus and method for topographic display of multichannel EEG data
US4766728A (en) * 1983-03-28 1988-08-30 Rexa Corporation Flow matching valve and hydraulic system employing same
US4417591A (en) 1980-12-31 1983-11-29 Braintech, Inc. Apparatus and method for topographic display of multichannel EEG data
US4498080A (en) * 1980-12-31 1985-02-05 Braintech, Inc. Apparatus and method for topographic display of multichannel data
US4378817A (en) * 1981-07-06 1983-04-05 Superior Valve Corporation Slide valve assembly
EP0091908A1 (en) 1981-10-21 1983-10-26 SMITH, Charles E A method and composition for substrate coating
US4790881A (en) 1982-03-26 1988-12-13 Warner-Lambert Company Molded hydrophilic polymer
EG16028A (en) * 1982-03-26 1986-12-30 Warner Lambert Co Apparatus and method for molding capsules
US4655840A (en) * 1982-03-26 1987-04-07 Warner-Lambert Company Hydrophilic polymer compositions for injection molding
FR2524311A1 (fr) 1982-04-05 1983-10-07 Azalbert Gilles Gelule compartimentee aux fins d'ingestions simultanees a effets differes
US4550238A (en) 1982-11-05 1985-10-29 Warner-Lambert Company Apparatus and method for sealing capsules
USD285837S (en) 1982-12-20 1986-09-23 Warner-Lambert Company Pharmaceutical capsule
US4487327A (en) 1982-12-21 1984-12-11 Grayson Robert E Locking capsule
US4625513A (en) 1983-03-28 1986-12-02 Rexa Corporation Controlled flow hydraulic system
US4696163A (en) 1983-03-28 1987-09-29 Rexa Corporation Control valve and hydraulic system employing same
US4557180A (en) 1983-03-28 1985-12-10 Rexa Corporation Control valve and hydraulic system employing same
US4543138A (en) 1983-07-07 1985-09-24 Eli Lilly & Company Capsule-sealing method and apparatus
US4564363A (en) * 1983-07-13 1986-01-14 Smithkline Beckman Corporation Delayed action assembly
US4576284A (en) * 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
US4738724A (en) * 1983-11-04 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from starch compositions
CH661878A5 (de) 1983-11-04 1987-08-31 Warner Lambert Co Kapsel-dosierungsformen.
US4738817A (en) * 1983-11-17 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from hydrophilic polymers
US4673438A (en) * 1984-02-13 1987-06-16 Warner-Lambert Company Polymer composition for injection molding
DE3581428D1 (de) 1984-06-13 1991-02-28 Roehm Gmbh Verfahren zum ueberziehen von arzneiformen.
US4629621A (en) * 1984-07-23 1986-12-16 Zetachron, Inc. Erodible matrix for sustained release bioactive composition
US5082655A (en) * 1984-07-23 1992-01-21 Zetachron, Inc. Pharmaceutical composition for drugs subject to supercooling
US4678516A (en) * 1984-10-09 1987-07-07 The Dow Chemical Company Sustained release dosage form based on highly plasticized cellulose ether gels
DE3438291A1 (de) * 1984-10-19 1986-04-24 Röhm GmbH, 6100 Darmstadt Verfahren zur herstellung einer waessrigen ueberzugsmitteldispersion und ihre verwendung zum ueberziehen von arzneimitteln
GB2172569A (en) 1985-03-21 1986-09-24 Warner Lambert Co Improved capsule construction
EP0211079A4 (en) 1985-01-31 1988-02-15 Fujisawa Pharmaceutical Co BENDABLE CAPSULE WITH SEVERAL CHAMBERS, METHOD AND DEVICE FOR THEIR PRODUCTION.
DE3524963A1 (de) 1985-07-12 1987-01-22 Scherer R P Hartkapsel Gmbh Zweiteilige steckkapsel
IL77186A0 (en) * 1985-11-29 1986-04-29 Touitou Elka Pharmaceutical insulin composition
DE3543912A1 (de) 1985-12-12 1987-06-19 Linde Ag Steuergeraet
ATE67401T1 (de) 1985-12-26 1991-10-15 Taisho Pharmaceutical Co Ltd Weiche nahtlose kapseln.
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
US4928840A (en) * 1986-02-25 1990-05-29 American Home Products Corporation Tamper proof encapsulated medicaments
CH674800A5 (es) 1986-03-12 1990-07-31 Warner Lambert Co
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
US4936461A (en) * 1986-09-18 1990-06-26 Makiej Jr Walter J Multidose capsules
US4793493A (en) 1986-09-18 1988-12-27 Makiej Jr Walter J Multidose capsules
DE3631826A1 (de) * 1986-09-19 1988-03-31 Roehm Gmbh Herstellung eines methylmethacrylat-copolymerisats
US5074426A (en) 1986-11-13 1991-12-24 Warner-Lambert Company Dividable capsule
KR890003520Y1 (ko) 1986-12-20 1989-05-27 주식회사 서흥캅셀 의약용 캅셀
US4724019A (en) * 1987-03-20 1988-02-09 Warner-Lambert Company Method and apparatus for sealing capsules
US5236689A (en) 1987-06-25 1993-08-17 Alza Corporation Multi-unit delivery system
US4795644A (en) * 1987-08-03 1989-01-03 Merck & Co., Inc. Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins
DE3727894A1 (de) 1987-08-21 1989-03-02 Stephan Dieter Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge
DE3735260A1 (de) * 1987-10-17 1989-04-27 Bosch Gmbh Robert Verschliessvorrichtung fuer zweiteilige kapseln
DE3830013C2 (de) 1988-09-03 1996-10-17 Bosch Gmbh Robert Füll- und Schließmaschine für zweiteilige Kapseln
US4944906A (en) 1988-10-11 1990-07-31 Spirex Corporation Methods of injection molding and extruding wet hygroscopic ionomers
US5244668A (en) 1988-10-14 1993-09-14 Zetachron, Inc. Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
US5139790A (en) 1988-10-14 1992-08-18 Zetachron, Inc. Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
US5004601A (en) * 1988-10-14 1991-04-02 Zetachron, Inc. Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
US5135752A (en) 1988-10-14 1992-08-04 Zetachron, Inc. Buccal dosage form
US4936074A (en) * 1988-11-17 1990-06-26 D. M. Graham Laboratories, Inc. Process for preparing solid encapsulated medicament
DE3902653A1 (de) * 1989-01-30 1990-08-02 Roehm Gmbh Elastomere acrylharze
US6200600B1 (en) * 1989-02-16 2001-03-13 Btg International Limited Controlled delay release device
DE3907019A1 (de) * 1989-03-04 1990-09-06 Roehm Gmbh Thermoplastisch verarbeitbare loesungsmittelbestaendige kunststoffmischungen
JPH0729926B2 (ja) 1989-07-25 1995-04-05 大塚製薬株式会社 易吸収性製剤用組成物
US5456919A (en) 1989-12-29 1995-10-10 Bristol-Myers Squibb Company Capsule and caplet combination
DE4002904A1 (de) * 1990-02-01 1991-08-08 Roehm Gmbh Verfahren zum imidieren eines methacrylester-polymerisats
FI933397A7 (fi) * 1991-01-30 1993-07-29 Alza Corp Osmoottinen laite aineen viivästettyyn vapauttamiseen
US5387421A (en) * 1991-01-31 1995-02-07 Tsrl, Inc. Multi stage drug delivery system
US5976571A (en) * 1991-01-31 1999-11-02 Port Systems, L.L.C. Method for making a multi-stage drug delivery system
US5674530A (en) 1991-01-31 1997-10-07 Port Systems, L.L.C. Method for making a multi-stage drug delivery system
CA2068402C (en) * 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets
DE4121652A1 (de) 1991-06-29 1993-01-07 Roehm Gmbh Schlagzaeh-modifizierungsmittel
US5225202A (en) * 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
DE4138513A1 (de) 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
GB9223144D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Controlled release device
GB9223172D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Capsule construction
US5312008A (en) * 1993-05-26 1994-05-17 Davis Bradford L Personal time capsule
WO1996010996A1 (en) * 1993-07-21 1996-04-18 The University Of Kentucky Research Foundation A multicompartment hard capsule with control release properties
US5443461A (en) 1993-08-31 1995-08-22 Alza Corporation Segmented device for simultaneous delivery of multiple beneficial agents
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
DE4402666A1 (de) 1994-01-29 1995-08-03 Roehm Gmbh Verfahren zum kurzzeitigen Behandeln einer Kunststoffschmelze mit einem flüssigen Behandlungsmittel und dabei hergestellter thermoplastischer Kunststoff
DE4413350A1 (de) 1994-04-18 1995-10-19 Basf Ag Retard-Matrixpellets und Verfahren zu ihrer Herstellung
ES2188657T3 (es) 1994-04-22 2003-07-01 Yamanouchi Pharma Co Ltd Sistema para la liberacion especifica en el colon de un farmaco.
DE19509807A1 (de) * 1995-03-21 1996-09-26 Basf Ag Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen
DE9414066U1 (de) * 1994-08-31 1994-11-03 Röhm GmbH & Co. KG, 64293 Darmstadt Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform
DE9414065U1 (de) * 1994-08-31 1994-11-03 Röhm GmbH & Co. KG, 64293 Darmstadt Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen
DE4445498A1 (de) * 1994-12-20 1996-06-27 Roehm Gmbh Universell verträgliche Pigmentdispergatoren
DE19504831A1 (de) 1995-02-14 1996-09-05 Basf Ag Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose
DE19504832A1 (de) 1995-02-14 1996-08-22 Basf Ag Feste Wirkstoff-Zubereitungen
DE29502547U1 (de) 1995-02-16 1995-03-30 Röhm GmbH, 64293 Darmstadt Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
DE19509805A1 (de) * 1995-03-21 1996-09-26 Basf Ag Transparente, schnell freisetzende Zubereitungen von nichtsteroidalen Analgetica
SG80553A1 (en) 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
DE19531277A1 (de) * 1995-08-25 1997-02-27 Basf Ag Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren
US5769267A (en) * 1995-11-09 1998-06-23 Warner-Lambert Company Container
DE19544562B4 (de) 1995-11-30 2004-05-27 Röhm GmbH & Co. KG Verfahren zur Herstellung von Poly(meth)acrylimiden mit bei thermischer Belastung verbesserter Farbstabilität und daraus erhältliche Formkörper
DE19701441C2 (de) * 1997-01-17 1998-11-05 Roehm Gmbh Verfahren zur Herstellung farbneutraler Polymethylmethacrylat-Formmassen
DE19718597C1 (de) 1997-05-02 1999-01-07 Roehm Gmbh Zweistufiges Verfahren zur Entwässerung von Kunststoffdispersionen
DE19721467A1 (de) * 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
CA2290966C (en) * 1997-07-01 2005-12-20 Pfizer Inc. Sertraline salts and sustained-release dosage forms of sertraline
DE19733505A1 (de) 1997-08-01 1999-02-04 Knoll Ag Schnell wirksames Analgeticum
DE19753299A1 (de) 1997-12-01 1999-06-02 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19753300A1 (de) 1997-12-01 1999-06-02 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19753298A1 (de) * 1997-12-01 1999-06-02 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19800927A1 (de) 1998-01-13 1999-07-15 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
DE19843904A1 (de) * 1998-09-24 2000-03-30 Basf Ag Feste Dosierungsform mit polymerem Bindemittel
US6139875A (en) 1998-09-29 2000-10-31 Eastman Chemical Company Aqueous enteric coating composition and low gastric permeability enteric coating
MXPA01005346A (es) * 1998-11-27 2003-03-27 Kanji Takada Una formulacion oral para suministro de farmaco gastrointestinal.
US6797283B1 (en) * 1998-12-23 2004-09-28 Alza Corporation Gastric retention dosage form having multiple layers
IT1316684B1 (it) * 1999-03-13 2003-04-24 Bosch Gmbh Robert Supporto delle parti di capsule in una macchina di caricamento e dichiusura per capsule in due parti
US6248807B1 (en) * 1999-03-15 2001-06-19 Fina Technology, Inc. Method for the preparation of core-shell morphologies from polybutadiene-polystyrene graft copolymers
DE19914605A1 (de) * 1999-03-30 2000-10-05 Roehm Gmbh Polyalkylmethacrylat-Plastisole mit verbesserten Fließeigenschaften
EP1204410B1 (en) * 1999-07-30 2012-09-12 Capsugel Belgium NV Multi-component pharmaceutical dosage form
DE19958007A1 (de) * 1999-12-02 2001-06-07 Roehm Gmbh Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
DE19960494A1 (de) * 1999-12-15 2001-06-21 Knoll Ag Vorrichtung und Verfahren zum Herstellen von festen wirkstoffhaltigen Formen
DE19961334A1 (de) * 1999-12-17 2001-06-21 Roehm Gmbh Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
IL150895A0 (en) * 2000-02-18 2003-02-12 Teva Pharma Oral, nasal and pulmonary formulations of copolymer-1
US6551617B1 (en) * 2000-04-20 2003-04-22 Bristol-Myers Squibb Company Taste masking coating composition
US6270797B1 (en) * 2000-05-18 2001-08-07 Usv Limited Sustained release pharmaceutical composition containing glipizide and method for producing same
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
DE10043868A1 (de) * 2000-09-04 2002-04-04 Roehm Gmbh PMMA Formmassen mit verbesserter Schlagzähigkeit
DE10054051A1 (de) * 2000-10-31 2002-05-29 Roehm Gmbh PMMA-Formmasse mit verbesserter Kälteschlagzähigkeit
US7842308B2 (en) * 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US20050175687A1 (en) 2001-01-30 2005-08-11 Mcallister Stephen M. Pharmaceutical formulations
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
DE10127134A1 (de) * 2001-06-05 2002-12-12 Roehm Gmbh verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß
JP4426286B2 (ja) * 2001-07-10 2010-03-03 テバ ファーマシューティカル インダストリーズ リミティド ０次、０次−二相性、上昇型又は下降型薬物放出のための薬物送達システム
US6949154B2 (en) * 2001-07-28 2005-09-27 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules
US7217381B2 (en) * 2001-09-28 2007-05-15 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
USD481456S1 (en) * 2002-01-30 2003-10-28 Smithkline Beecham P.L.C. Capsule
DE10204890A1 (de) * 2002-02-06 2003-08-14 Roehm Gmbh Schlagzähe Formmasse und Formkörper
US20030194429A1 (en) 2002-04-10 2003-10-16 Miller Frederick H. Multi-phase, multi-compartment capsular delivery apparatus for therapeutic compositions and methods for using same
US7670612B2 (en) * 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
TWI336260B (en) * 2002-07-25 2011-01-21 Glaxo Group Ltd Dosage form suitable for retaining drug substance
USD506545S1 (en) * 2002-07-29 2005-06-21 Smithkline Beecham P.L.C. Capsule linker
DE10243062A1 (de) 2002-09-16 2004-03-25 Röhm GmbH & Co. KG Heißwasserwechseltestbeständiges Sanitärmaterial aus PMMA-Formmasse oder schlagzäher PMMA-Formmasse
DE10260065A1 (de) * 2002-12-19 2004-07-01 Röhm GmbH & Co. KG Kern-Schale-Teilchen zur Schlagzähmodifizierung von Poly(meth)acrylat-Formmassen
DE10260089A1 (de) * 2002-12-19 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von wässrigen Dispersionen
DE10329938A1 (de) * 2003-07-02 2005-03-17 Röhm GmbH & Co. KG Kunststoffkörper mit mikrostrukturierter Oberfläche
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
DE10349142A1 (de) * 2003-10-17 2005-05-12 Roehm Gmbh Polymermischung sowie deren Verwendung für Spritzgußteile
DE10349144A1 (de) * 2003-10-17 2005-05-12 Roehm Gmbh Polymermischung für mattierte Spritzgußteile
DE10351535A1 (de) * 2003-11-03 2005-06-09 Röhm GmbH & Co. KG Mehrschichtfolie aus (Meth)acrylatcopolymer und Polycarbonat
DE10354379A1 (de) * 2003-11-20 2005-06-23 Röhm GmbH & Co. KG Formmasse, enthaltend ein Mattierungsmittel
JP2007517908A (ja) 2004-01-16 2007-07-05 グラクソ　グループ　リミテッド 腸溶性ポリマー中における脂質基材の処方のカプセル封入
DE102004022540A1 (de) 2004-05-05 2005-12-08 Röhm GmbH & Co. KG Formmasse für Formkörper mit hoher Witterungsbeständigkeit
JP4354360B2 (ja) * 2004-07-26 2009-10-28 Ｏｋｉセミコンダクタ株式会社 降圧電源装置
DE102004045296A1 (de) 2004-09-16 2006-03-23 Röhm GmbH & Co. KG Verwendung von Polyalkyl (meth) acrylat-Perlpolymerisaten und Formmasse zur Herstellung von extrudierten Formteilen mit mattierter Oberfläche
US9713592B2 (en) 2005-04-06 2017-07-25 Mallinckrodt Llc Matrix-based pulse release pharmaceutical formulation
EP2209456B1 (en) * 2007-10-15 2013-03-06 Capsugel Belgium NV Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms
WO2009050189A2 (en) * 2007-10-15 2009-04-23 Glaxo Group Limited Multipart capsule for staged release of one or more substances
US8454992B2 (en) * 2007-10-15 2013-06-04 Capsugel Belgium Nv Paneled capsule shells for release of pharmaceutical compositions
CN101827573A (zh) * 2007-10-15 2010-09-08 葛兰素集团有限公司 已装填的连接件的制造装置和方法
EP2219624A2 (en) * 2007-11-08 2010-08-25 Glaxo Group Limited Pharmaceutical formulations
AU2009256572A1 (en) * 2008-06-13 2009-12-17 Capsugel Belgium Nv Hydroxypropyl cellulose capsule shell

Also Published As

Publication number Publication date
IL177566A (en) 2011-03-31
IL177566A0 (en) 2006-12-10
CN1953739B (zh) 2011-12-14
BRPI0508342A (pt) 2007-07-24
AU2005222612A1 (en) 2005-09-29
US8147871B2 (en) 2012-04-03
MA28489B1 (fr) 2007-03-01
CA2559227A1 (en) 2005-09-29
US20120196940A1 (en) 2012-08-02
RU2011127852A (ru) 2013-01-20
KR101242988B1 (ko) 2013-03-13
TW201240679A (en) 2012-10-16
US20070178156A1 (en) 2007-08-02
JP2007528901A (ja) 2007-10-18
NZ549264A (en) 2010-07-30
US20050249807A1 (en) 2005-11-10
JP2012097088A (ja) 2012-05-24
NO20064570L (no) 2006-10-10
RU2447885C2 (ru) 2012-04-20
EP1729744A1 (en) 2006-12-13
RU2006136020A (ru) 2008-04-20
CN1953739A (zh) 2007-04-25
TW200539903A (en) 2005-12-16
KR20130010511A (ko) 2013-01-28
PE20060003A1 (es) 2006-03-01
KR20070002004A (ko) 2007-01-04
AU2005222612B2 (en) 2011-04-21
WO2005089726A1 (en) 2005-09-29
EP1729744A4 (en) 2012-10-31
KR20120044365A (ko) 2012-05-07
AU2005222612C1 (en) 2011-12-08

Similar Documents

Publication Publication Date Title
AR048033A1 (es) Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion
AR032524A1 (es) Composicion farmaceutica para capsulas moldeadas; composicion farmaceutica para envueltas de capsulas moldeadas; envuelta, elemento de union o separador de capsula moldeados por inyeccion con las mismas; forma de dosificacion farmaceutica de varios componentes y conjunto de formas de dosificacion de
SV2008003106A (es) Composicion farmaceutica estable que contiene docetaxel y un metodo para fabricarla
MX2010005092A (es) Formulaciones farmaceuticas.
BRPI0707044B8 (pt) comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais
CL2003002277A1 (es) Composicion farmaceutica inyectable, de deposito de liberacion prolongada, que comprende un agente beneficioso disuelto o disperso en un gel constituido por un polimero bioerosionable y biocompatible; y un solvente.
TN2009000093A1 (en) Pharmaceutical compositions comprising nilotinib or its salt
WO2006039704A3 (en) Pharmaceutical composition and method for treating a joint capsule arthropathy
MX2010013731A (es) Cubierta de capsula de hidroxipropil celulosa.
EA200801926A1 (ru) Таблетки парацетамола с быстрым высвобождением
MX2009004439A (es) Composicion de ibuprofeno.
WO2011116139A3 (en) Improved pharmaceutical compositions comprising cck- 8 and methods of delivery
WO2006011159A3 (en) Stabilized pharmaceutical composition containing rabeprazole sodium with improved bioavailability
AR046399A1 (es) Composicion farmaceutica para componentes moldeados, cubierta de capsula, material de union o de separacion moldeado por inyeccion que la comprende y forma de dosificacion farmaceutica multicomponente
BRPI0515815A (pt) forma medicamentosa de multipartìculas contendo substáncias ativas de ácido nucléico formuladas mucoadesivas bem como processo para preparação da forma medicamentosa
BRPI0411752A (pt) implantes subcutáneos apresentando liberação inicial limitada do princìpio ativo e liberação ampliada subseqüente linearmente variável do mesmo
BR112015027024A2 (pt) formulações de gel para liberação prolongada de compostos voláteis
UY29395A1 (es) Formulación de medicamentos conteniendo vardenafilo.
AR054238A1 (es) Composicion farmaceutica que contiene una biguanida y un derivado de tiazolidindiona
AR060869A1 (es) Composicion farmaceutica solida de gabapentina
PT1499278E (pt) Forma de dosagem farmaceutica de libertacao imediata compreendendo tibolona polimorfa
WO2008037224A3 (es) Forma de dosificación de liberación controlada que contiene lercanidipina y un ácido que mejora el funcionamiento
TH144451A (th) อนุภาคเชิงซ้อนของสารที่ถูกฉีดเมื่ออยู่ในสภาวะหลอมละลาย
BR0202759A (pt) Composição farmacêutica de liberação modificada contendo bupropiona como substância ativa
EA200701010A1 (ru) Препарат гепирона с высокой дозировкой и длительным высвобождением

Legal Events

Date Code Title Description
FB Suspension of granting procedure