BRPI0408300A - processo para a preparação de derivados de fenetilamina - Google Patents

processo para a preparação de derivados de fenetilamina

Info

Publication number
BRPI0408300A
BRPI0408300A BRPI0408300-8A BRPI0408300A BRPI0408300A BR PI0408300 A BRPI0408300 A BR PI0408300A BR PI0408300 A BRPI0408300 A BR PI0408300A BR PI0408300 A BRPI0408300 A BR PI0408300A
Authority
BR
Brazil
Prior art keywords
alkyl
hydrogen
preparation
compound
formula
Prior art date
Application number
BRPI0408300-8A
Other languages
English (en)
Inventor
Keun-Sik Kim
Kwang-Il Kim
Ki-Byung Chai
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32990789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0408300(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0408300A publication Critical patent/BRPI0408300A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE FENETILAMINA". A presente invenção refere-se a um processo para a preparação de um composto de fórmula (I), na qual R~1~ E R~ 2~ são substituintes orto ou para, independentemente selecionados do grupo que consiste em hidrogênio, hidroxila, C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ alcóxi, C~ 7~-C~ 9~ aralcóxi, C~ 2~-C~ 7~ alcanoilóxi, C~ 1~-C~ 6~ alquilmercapto, halo ou trifluormetila; R~ 3~ é hidrogênio ou C~ 1~-C~ 6~ alquila; R~ 4~ é hidrogênio, C~ 1~-C~ 6~-alquila, formila ou C~ 2~-C~ 7~ alcanoíla; n é um dos inteiros 0, 1, 2, 3, ou 4; e a linha tracejada representa insaturação olefínica opcional; compreendendo a hidrogenação de um composto de fórmula (III), na presença de um catalisador de níquel ou cobalto a uma temperatura de 50C até 250C.
BRPI0408300-8A 2003-03-11 2004-03-09 processo para a preparação de derivados de fenetilamina BRPI0408300A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45358303P 2003-03-11 2003-03-11
PCT/US2004/007861 WO2004080934A2 (en) 2003-03-11 2004-03-09 Process for preparation of phenethylamine derivatives

Publications (1)

Publication Number Publication Date
BRPI0408300A true BRPI0408300A (pt) 2006-03-07

Family

ID=32990789

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408300-8A BRPI0408300A (pt) 2003-03-11 2004-03-09 processo para a preparação de derivados de fenetilamina

Country Status (20)

Country Link
US (2) US7179944B2 (pt)
EP (1) EP1601640A2 (pt)
JP (1) JP2006520391A (pt)
KR (1) KR20050106102A (pt)
CN (1) CN100480231C (pt)
AR (1) AR043538A1 (pt)
AU (1) AU2004220055A1 (pt)
BR (1) BRPI0408300A (pt)
CA (1) CA2517164A1 (pt)
CL (1) CL2004000492A1 (pt)
CO (1) CO5611119A2 (pt)
CR (1) CR7959A (pt)
EC (1) ECSP056012A (pt)
MX (1) MXPA05009555A (pt)
NO (1) NO20054300L (pt)
RU (1) RU2005131420A (pt)
SG (1) SG160193A1 (pt)
TW (1) TWI306092B (pt)
WO (1) WO2004080934A2 (pt)
ZA (1) ZA200507297B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
AU2002250058B2 (en) 2001-02-12 2007-08-16 Wyeth Llc Novel succinate salt of O-desmethyl-venlafaxine
WO2006067808A1 (en) * 2004-12-22 2006-06-29 Calyx Chemicals & Pharmaceuticals Private Limited An improved process for production of intermediate of antidepressant agent
US7196223B2 (en) * 2005-05-03 2007-03-27 Solutia, Inc. Higher alcohols for solvents in amine production
CN1955159B (zh) * 2005-06-17 2010-11-24 山东绿叶制药有限公司 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途
WO2007005961A2 (en) * 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
KR20080056311A (ko) * 2005-10-19 2008-06-20 테바 파마슈티컬 인더스트리즈 리미티드 고순도1-[2-디메틸아미노-(4-메톡시페닐)에틸)시클로헥산올염산염의 제조 방법
EP2043999A2 (en) * 2005-11-30 2009-04-08 Aarti Healthcare Limited A process for the preparation of venlafaxine hydrochloride
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
WO2008013995A2 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
US20090062572A1 (en) * 2006-07-26 2009-03-05 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US20100121108A1 (en) * 2006-08-04 2010-05-13 Medichem, S.A. Process for synthesizing desvenlafaxine free base and salts or solvates thereof
WO2008109093A1 (en) * 2007-03-06 2008-09-12 Exxonmobil Research And Engineering Company Fiber reinforced polypropylene composite front end modules
EP2297087A2 (en) * 2008-06-16 2011-03-23 Teva Pharmaceutical Industries Ltd. Solid states of o-desmethylvenlaf axine salts
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
WO2010100520A1 (en) * 2009-03-04 2010-09-10 Hikal Limited A process for preparation of phenethylamine derivative
EP2539313A2 (en) * 2010-03-29 2013-01-02 Pliva Hrvatska D.O.O. Crystal forms of o-desmethylvenlafaxine fumarate
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
US8933123B2 (en) 2010-10-08 2015-01-13 Cadila Healthcare Limited Polymorphic forms of O-desmethyl-venlafaxine succinate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
JP2811065B2 (ja) 1985-12-02 1998-10-15 ダイセル化学工業株式会社 ベンジルアミンの製造法
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
HU225019B1 (en) * 2000-12-20 2006-05-29 Ciba Sc Holding Ag Process for the preparation of phenethylamine derivatives
WO2002050012A1 (en) * 2000-12-21 2002-06-27 Inca International S.P.A. Use of osmotic membranes in therephthalic acid production

Also Published As

Publication number Publication date
US7563931B2 (en) 2009-07-21
KR20050106102A (ko) 2005-11-08
CL2004000492A1 (es) 2005-02-04
US20070149813A1 (en) 2007-06-28
NO20054300L (no) 2005-09-30
SG160193A1 (en) 2010-04-29
AU2004220055A1 (en) 2004-09-23
EP1601640A2 (en) 2005-12-07
ZA200507297B (en) 2010-02-24
US7179944B2 (en) 2007-02-20
MXPA05009555A (es) 2005-10-19
CR7959A (es) 2006-05-31
JP2006520391A (ja) 2006-09-07
RU2005131420A (ru) 2006-04-20
CN100480231C (zh) 2009-04-22
AR043538A1 (es) 2005-08-03
CO5611119A2 (es) 2006-02-28
US20040181093A1 (en) 2004-09-16
WO2004080934A3 (en) 2004-10-28
ECSP056012A (es) 2006-01-27
WO2004080934A2 (en) 2004-09-23
CN1756733A (zh) 2006-04-05
TWI306092B (en) 2009-02-11
CA2517164A1 (en) 2004-09-23
TW200427657A (en) 2004-12-16

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.