ECSP056012A - Proceso para preparar derivados de feniltilamina - Google Patents

Proceso para preparar derivados de feniltilamina

Info

Publication number
ECSP056012A
ECSP056012A EC2005006012A ECSP056012A ECSP056012A EC SP056012 A ECSP056012 A EC SP056012A EC 2005006012 A EC2005006012 A EC 2005006012A EC SP056012 A ECSP056012 A EC SP056012A EC SP056012 A ECSP056012 A EC SP056012A
Authority
EC
Ecuador
Prior art keywords
hydrogen
alkyl
phenyltilamine
compound
formula
Prior art date
Application number
EC2005006012A
Other languages
English (en)
Inventor
Keun-Sik Kim
Ki Ki-Byung Chai
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32990789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP056012(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP056012A publication Critical patent/ECSP056012A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Proceso para preparar un compuesto de fórmula (I), en donde R, y R2 son sustituyentes en posición orto o para, seleccionado; independientemente entre el grupo integrado por hidrógeno, hidroxilo alquilo de 1 a 6 C, alcoxilo de 1 a 6 C, arilalcoxilo de 7 a 9 C alcanoiloxilo de 2 a 7 C, alquilmercapto de 1 a 6 C, halógeno y trifluorometilo; R3 es hidrógeno o alquilo de 1 a 6 C; R4 es hidrógeno alquilo de 1 a 6 C, formilo o alcanoílo de 2 a 7 C; n es un número entero que puede ser O, 1. 2, 3 ó 4; y la línea de puntos representa una insaturación olefínica opcional; que comprende la hidrogenación de un compuesto de fórmula (III), en presencia de un catalizador de níquel o de cobalto a una temperatura entre aproximadamente 5 °C y 25 °C.
EC2005006012A 2003-03-11 2005-09-12 Proceso para preparar derivados de feniltilamina ECSP056012A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45358303P 2003-03-11 2003-03-11

Publications (1)

Publication Number Publication Date
ECSP056012A true ECSP056012A (es) 2006-01-27

Family

ID=32990789

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006012A ECSP056012A (es) 2003-03-11 2005-09-12 Proceso para preparar derivados de feniltilamina

Country Status (20)

Country Link
US (2) US7179944B2 (es)
EP (1) EP1601640A2 (es)
JP (1) JP2006520391A (es)
KR (1) KR20050106102A (es)
CN (1) CN100480231C (es)
AR (1) AR043538A1 (es)
AU (1) AU2004220055A1 (es)
BR (1) BRPI0408300A (es)
CA (1) CA2517164A1 (es)
CL (1) CL2004000492A1 (es)
CO (1) CO5611119A2 (es)
CR (1) CR7959A (es)
EC (1) ECSP056012A (es)
MX (1) MXPA05009555A (es)
NO (1) NO20054300L (es)
RU (1) RU2005131420A (es)
SG (1) SG160193A1 (es)
TW (1) TWI306092B (es)
WO (1) WO2004080934A2 (es)
ZA (1) ZA200507297B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
DE60221642T3 (de) 2001-02-12 2017-10-26 Wyeth LLC (n.d.Ges.d. Staates Delaware) O-desmethyl-venlafaxine succinat salz
WO2006067808A1 (en) * 2004-12-22 2006-06-29 Calyx Chemicals & Pharmaceuticals Private Limited An improved process for production of intermediate of antidepressant agent
US7196223B2 (en) * 2005-05-03 2007-03-27 Solutia, Inc. Higher alcohols for solvents in amine production
CN1955159B (zh) 2005-06-17 2010-11-24 山东绿叶制药有限公司 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途
JP2009500420A (ja) * 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びｏ−デスメチルベンラファキシンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
KR20080056311A (ko) * 2005-10-19 2008-06-20 테바 파마슈티컬 인더스트리즈 리미티드 고순도1-[2-디메틸아미노-(4-메톡시페닐)에틸)시클로헥산올염산염의 제조 방법
WO2007069277A2 (en) * 2005-11-30 2007-06-21 Aarti Healthcare Limited A process for the preparation of venlafaxine hydrochloride
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
EP1934167A2 (en) * 2006-07-26 2008-06-25 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
CA2656285A1 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
WO2008015584A2 (en) * 2006-08-04 2008-02-07 Medichem, S.A. Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof
WO2008109093A1 (en) * 2007-03-06 2008-09-12 Exxonmobil Research And Engineering Company Fiber reinforced polypropylene composite front end modules
KR20100132069A (ko) * 2008-06-16 2010-12-16 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신염의 고체 상태
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
WO2010100520A1 (en) * 2009-03-04 2010-09-10 Hikal Limited A process for preparation of phenethylamine derivative
WO2011121452A2 (en) * 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Crystal forms of o-desmethylvenlafaxine fumarate
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
US8933123B2 (en) 2010-10-08 2015-01-13 Cadila Healthcare Limited Polymorphic forms of O-desmethyl-venlafaxine succinate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
JP2811065B2 (ja) 1985-12-02 1998-10-15 ダイセル化学工業株式会社 ベンジルアミンの製造法
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
AU2002238421A1 (en) * 2000-12-20 2002-07-01 Ciba Specialty Chemicals Holding Inc. Process for the preparation of phenethylamine derivatives
AU2002220961A1 (en) * 2000-12-21 2002-07-01 Inca International S.P.A. Use of osmotic membranes in therephthalic acid production

Also Published As

Publication number Publication date
RU2005131420A (ru) 2006-04-20
US7179944B2 (en) 2007-02-20
SG160193A1 (en) 2010-04-29
WO2004080934A2 (en) 2004-09-23
EP1601640A2 (en) 2005-12-07
AR043538A1 (es) 2005-08-03
US7563931B2 (en) 2009-07-21
CL2004000492A1 (es) 2005-02-04
US20070149813A1 (en) 2007-06-28
CR7959A (es) 2006-05-31
TWI306092B (en) 2009-02-11
CN100480231C (zh) 2009-04-22
CO5611119A2 (es) 2006-02-28
BRPI0408300A (pt) 2006-03-07
CN1756733A (zh) 2006-04-05
KR20050106102A (ko) 2005-11-08
MXPA05009555A (es) 2005-10-19
AU2004220055A1 (en) 2004-09-23
JP2006520391A (ja) 2006-09-07
ZA200507297B (en) 2010-02-24
US20040181093A1 (en) 2004-09-16
NO20054300L (no) 2005-09-30
WO2004080934A3 (en) 2004-10-28
TW200427657A (en) 2004-12-16
CA2517164A1 (en) 2004-09-23

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