BRPI0408613A - revestimento antifúngico de unhas e método de uso - Google Patents

revestimento antifúngico de unhas e método de uso

Info

Publication number
BRPI0408613A
BRPI0408613A BRPI0408613-9A BRPI0408613A BRPI0408613A BR PI0408613 A BRPI0408613 A BR PI0408613A BR PI0408613 A BRPI0408613 A BR PI0408613A BR PI0408613 A BRPI0408613 A BR PI0408613A
Authority
BR
Brazil
Prior art keywords
fungicidal
composition
coat
amount
antifungal
Prior art date
Application number
BRPI0408613-9A
Other languages
English (en)
Inventor
Stanley W Kepka
Y Joseph Mo
Hang-Yong Wang
Mingqi Lu
William R Pfister
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of BRPI0408613A publication Critical patent/BRPI0408613A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/806—Drug, bio-affecting and body treating compositions involving IgM
    • Y10S424/807—Monoclonal
    • Y10S424/808—Human

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"REVESTIMENTO ANTIFúNGICO DE UNHAS E MéTODO DE USO". A presente invenção refere-se a uma composição antifúngica de revestimento de unhas de ação dupla e método de uso para melhorar ou prevenir a infecção fúngica nas unhas, e onicomicose, particularmente. As modalidades da composição na forma de um tipo de um revestimento e um tipo de dois revestimentos apropriados para regimes fungicidas diários são descritas. Uma composição antifúngica de revestimento de unhas preferida compreende uma quantidade fungicida eficaz de um agente antifúngico, uma quantidade melhoradora de permeação de um melhorador de permeação substancialmente não volátil, uma quantidade formadora de película de um polímero hidrofílico, e um veículo sólido farmaceuticamente aceitável. A composição provê um revestimento fungicida substancialmente solúvel em água em contato com uma unha infectada ou susceptível fungicamente.
BRPI0408613-9A 2003-03-21 2004-03-22 revestimento antifúngico de unhas e método de uso BRPI0408613A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45668403P 2003-03-21 2003-03-21
PCT/US2004/008618 WO2004084826A2 (en) 2003-03-21 2004-03-22 Antifungal nail coat and method of use

Publications (1)

Publication Number Publication Date
BRPI0408613A true BRPI0408613A (pt) 2006-03-07

Family

ID=33098141

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408613-9A BRPI0408613A (pt) 2003-03-21 2004-03-22 revestimento antifúngico de unhas e método de uso

Country Status (28)

Country Link
US (3) US7462362B2 (pt)
EP (2) EP2106805B1 (pt)
JP (1) JP4540667B2 (pt)
KR (1) KR101093990B1 (pt)
CN (2) CN102973420A (pt)
AT (2) ATE432087T1 (pt)
AU (1) AU2004224326B2 (pt)
BR (1) BRPI0408613A (pt)
CA (1) CA2519705C (pt)
CO (1) CO5640092A2 (pt)
CY (1) CY1111773T1 (pt)
DE (1) DE602004021253D1 (pt)
DK (2) DK2106805T3 (pt)
EC (1) ECSP056110A (pt)
ES (1) ES2366273T3 (pt)
HR (1) HRP20050918A2 (pt)
IL (1) IL170963A (pt)
IS (1) IS8078A (pt)
MA (1) MA27760A1 (pt)
MX (1) MXPA05010114A (pt)
NO (1) NO335895B1 (pt)
NZ (1) NZ542904A (pt)
PL (1) PL2106805T3 (pt)
RU (1) RU2358718C2 (pt)
SG (1) SG152065A1 (pt)
TN (1) TNSN05231A1 (pt)
WO (1) WO2004084826A2 (pt)
ZA (1) ZA200507972B (pt)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050238672A1 (en) * 2004-04-27 2005-10-27 Nimni Marcel E Antifungal drug delivery
MX2007006833A (es) * 2004-12-10 2007-10-08 Talima Therapeutics Inc Composiciones y metodos para tratar condiciones de la unidad de una.
US20060275230A1 (en) * 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
EP1698336A1 (en) * 2005-03-01 2006-09-06 Ferrer Internacional, S.A. Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent
FR2892023B1 (fr) * 2005-10-14 2009-09-25 Galderma Sa Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale
AU2006332425A1 (en) * 2006-01-02 2007-07-12 Tlt Medical Ltd. Pharmaceutical composition for the treatment of nail diseases
WO2007098591A2 (en) * 2006-03-02 2007-09-07 Nuvo Research Inc. Topical nail formulation
MX2008011435A (es) 2006-03-08 2009-02-03 Nihon Nohyaku Co Ltd Composicion farmaceutica para uso externo.
US8058303B2 (en) 2006-03-08 2011-11-15 Nihon Nohyaku Co, Ltd Pharmaceutical composition for external use
AU2006339841B2 (en) * 2006-03-08 2012-08-30 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
JP5529539B2 (ja) 2007-09-05 2014-06-25 株式会社ポーラファルマ 医薬組成物
JP5453093B2 (ja) 2007-09-05 2014-03-26 株式会社ポーラファルマ 抗真菌医薬組成物
JP5345937B2 (ja) 2007-09-05 2013-11-20 株式会社ポーラファルマ 抗真菌組成物
US20090175810A1 (en) * 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
CA2739376A1 (en) 2008-10-03 2010-04-08 Nexmed Holdings, Inc. Stabilized composition for treating psoriasis
CN102256602A (zh) * 2008-10-21 2011-11-23 诺沃德米克斯国际有限公司 用于治疗上皮组织的组合物
WO2010047288A1 (en) 2008-10-24 2010-04-29 Semiconductor Energy Laboratory Co., Ltd. Method for manufacturing semiconductordevice
CN108191846B (zh) * 2008-12-04 2021-08-20 于崇曦 高穿透性组合物及其应用
US20100291182A1 (en) * 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
JP2012516320A (ja) 2009-01-30 2012-07-19 イッスム リサーチ デベロプメント カンパニー オブ ザ ヘブライ ユニバーシティ オブ エルサレム リミテッド 爪および皮膚を処置するための組成物
WO2010086727A1 (en) * 2009-01-30 2010-08-05 Galderma Pharma Sa Stable compositions for nail onychomycosis treatment
US10130610B2 (en) 2009-04-09 2018-11-20 Pola Pharma Inc. Antimycotic pharmaceutical composition
EP2416758B8 (en) 2009-04-09 2017-10-18 Pola Pharma Inc. Antimycotic pharmaceutical composition
WO2011014850A2 (en) 2009-07-31 2011-02-03 Nuvo Research Inc. Topical eutectic-based formulations
US9173817B2 (en) 2009-08-24 2015-11-03 Arsenal Medical, Inc. In situ forming hemostatic foam implants
US12544491B2 (en) 2009-08-24 2026-02-10 Arsenal Medical, Inc. In situ forming hemostatic foam implants
US20110202016A1 (en) * 2009-08-24 2011-08-18 Arsenal Medical, Inc. Systems and methods relating to polymer foams
US9044580B2 (en) 2009-08-24 2015-06-02 Arsenal Medical, Inc. In-situ forming foams with outer layer
US10420862B2 (en) 2009-08-24 2019-09-24 Aresenal AAA, LLC. In-situ forming foams for treatment of aneurysms
WO2011024620A1 (en) 2009-08-25 2011-03-03 Pola Pharma Inc. Antimycotic pharmaceutical composition
JPWO2011052224A1 (ja) * 2009-11-02 2013-03-14 株式会社福元技研 皮膚美容用混練組成物およびその製造方法、皮膚美容用混練組成物の使用方法
AU2010336441B2 (en) 2009-12-23 2015-02-05 Nuvo Research Inc. Highly permeating terbinafine formulation for treating onychomycosis
SG10201600228QA (en) * 2010-05-04 2016-03-30 Nexmed Holdings Inc Therapeutic peptide composition and method
CN102858158A (zh) 2010-05-04 2013-01-02 尼克美控股公司 小分子治疗剂的组合物
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
RU2432158C1 (ru) * 2010-07-28 2011-10-27 Закрытое акционерное общество "Институт прикладной нанотехнологии" Профилактический бактерицидный лак для обработки ногтей
EP2646015B1 (en) * 2010-12-02 2020-04-22 Ferring International Center S.A. Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate
US9034240B2 (en) 2011-01-31 2015-05-19 Arsenal Medical, Inc. Electrospinning process for fiber manufacture
US9194058B2 (en) 2011-01-31 2015-11-24 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US8968626B2 (en) 2011-01-31 2015-03-03 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
CN103459394B (zh) * 2011-04-08 2016-04-27 辉瑞大药厂 结晶和非结晶形式的托法替尼，以及包含托法替尼和渗透增强剂的药物组合物
EP2707007B1 (en) * 2011-05-11 2018-03-07 Veloce BioPharma LLC Antifungal compositions for the treatment of nails
CA2745320A1 (en) 2011-07-06 2013-01-06 Duoject Medical Systems Inc. Reconstitution device
US8993831B2 (en) 2011-11-01 2015-03-31 Arsenal Medical, Inc. Foam and delivery system for treatment of postpartum hemorrhage
MX367393B (es) * 2012-02-17 2019-08-16 Veloce Biopharma Llc Composiciones antifungicas para el tratamiento de piel y uñas.
CA2775393C (en) * 2012-05-02 2014-04-29 Samy Saad Topical non-aqueous pharmaceutical formulations
US20150209301A1 (en) 2012-07-30 2015-07-30 Nichiban Company Limited Patch for anti-dermatophytosis
TW201410239A (zh) * 2012-07-30 2014-03-16 Meiji Seika Pharma Co Ltd 抗白癬菌症外用液劑
US8900625B2 (en) * 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
CN105377355A (zh) 2013-03-14 2016-03-02 拇趾公司 治疗甲单元的感染、疾病或病症的方法
WO2014159930A1 (en) * 2013-03-14 2014-10-02 Alc Therapeutics, Llc Antifungal compositions for the treatment of secondary skin and nail infections
GB201317005D0 (en) * 2013-09-25 2013-11-06 Blueberry Therapeutics Ltd Composition and methods of treatment
MX363386B (es) 2013-10-03 2019-03-20 Dow Pharmaceutical Sciences Formulaciones de efinaconazol estabilizadas.
KR102612453B1 (ko) 2013-11-22 2023-12-08 다우 파마슈티컬 사이언시즈, 인코포레이티드 항­감염 방법，조성물，및 장치
EP2952208A1 (en) * 2014-06-04 2015-12-09 Universidade de Santiago de Compostela Hydroalcoholic system for nail treatment
WO2016024602A1 (ja) 2014-08-13 2016-02-18 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 結晶性抗白癬菌薬およびその製造方法
KR20180011882A (ko) 2015-01-20 2018-02-02 벨로체 바이오파르마 엘엘씨 신규한 요오드포 조성물 및 사용 방법
JP6591100B1 (ja) * 2019-01-25 2019-10-16 ロート製薬株式会社 爪及び爪周り用医薬組成物
CN112791048B (zh) * 2020-12-31 2023-01-17 海南海神同洲制药有限公司 一种硝酸舍他康唑栓及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1410A (en) 1979-08-22 1988-04-22 Sandoz Ag Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
DE3045914A1 (de) 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
US4406509A (en) * 1981-11-25 1983-09-27 E. I. Du Pont De Nemours & Co. Jack and plug electrical assembly
DE3544983A1 (de) 1985-12-19 1987-06-25 Hoechst Ag Antimykotisch wirksamer nagellack
US4861764A (en) 1986-11-17 1989-08-29 Macro Chem. Corp. Percutaneous absorption enhancers, compositions containing same and method of use
FR2613227B1 (fr) * 1987-04-01 1990-12-28 Oreal Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles
US5082866A (en) * 1988-06-01 1992-01-21 Odontex, Inc. Biodegradable absorption enhancers
US4980378A (en) 1988-06-01 1990-12-25 Odontex, Inc. Biodegradable absorption enhancers
FR2673537B1 (fr) * 1991-03-08 1993-06-11 Oreal Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes.
HU219480B (hu) * 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
WO1995009590A1 (en) * 1993-10-07 1995-04-13 Odontex, Inc. Absorption enhancers for topical pharmaceutical formulations
US6019988A (en) * 1996-11-18 2000-02-01 Bristol-Myers Squibb Company Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
US6046244A (en) * 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
RU2141854C1 (ru) * 1998-11-25 1999-11-27 Закрытое акционерное общество "Интермед" Способ лечения грибковых заболеваний ногтей
US6118020A (en) 1999-05-19 2000-09-12 Nexmed Holdings, Inc. Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate
US6495124B1 (en) 2000-02-14 2002-12-17 Macrochem Corporation Antifungal nail lacquer and method using same
JP2005503318A (ja) 2000-02-16 2005-02-03 ベントレー ファーマシューティカルズ インコーポレイテッド 医薬組成物
US7074392B1 (en) * 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
AU2000255769A1 (en) * 2000-07-01 2002-01-14 Chemtech Research Incorporation Process for preparation of terbinafine and its hydrochloride as an antifungal agent
JP4899139B2 (ja) * 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
JP4803511B2 (ja) * 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
JP2002068975A (ja) * 2000-08-25 2002-03-08 Pola Chem Ind Inc 抗真菌医薬組成物
US6585963B1 (en) * 2001-02-15 2003-07-01 Watson Pharmaceuticals, Inc. Nail compositions and methods of administering same
US6846837B2 (en) * 2002-06-21 2005-01-25 Howard I. Maibach Topical administration of basic antifungal compositions to treat fungal infections of the nails

Also Published As

Publication number Publication date
JP4540667B2 (ja) 2010-09-08
NZ542904A (en) 2009-04-30
TNSN05231A1 (fr) 2007-06-11
CN102973420A (zh) 2013-03-20
US20130323189A1 (en) 2013-12-05
ZA200507972B (en) 2007-02-28
EP1635770A2 (en) 2006-03-22
DK1635770T3 (da) 2009-08-03
EP1635770B1 (en) 2009-05-27
WO2004084826A3 (en) 2004-11-04
NO20054830L (no) 2005-12-16
DE602004021253D1 (de) 2009-07-09
SG152065A1 (en) 2009-05-29
KR101093990B1 (ko) 2011-12-16
AU2004224326A1 (en) 2004-10-07
HRP20050918A2 (en) 2006-12-31
US7462362B2 (en) 2008-12-09
ECSP056110A (es) 2006-03-01
DK2106805T3 (da) 2011-08-15
WO2004084826A2 (en) 2004-10-07
EP1635770A4 (en) 2007-12-26
NO20054830D0 (no) 2005-10-19
AU2004224326B2 (en) 2010-04-22
MA27760A1 (fr) 2006-02-01
US20090099266A1 (en) 2009-04-16
CO5640092A2 (es) 2006-05-31
EP2106805B1 (en) 2011-06-15
CN1791378A (zh) 2006-06-21
ATE512672T1 (de) 2011-07-15
NO335895B1 (no) 2015-03-16
ES2366273T3 (es) 2011-10-18
RU2358718C2 (ru) 2009-06-20
CY1111773T1 (el) 2015-10-07
PL2106805T3 (pl) 2011-10-31
ATE432087T1 (de) 2009-06-15
JP2006520800A (ja) 2006-09-14
EP2106805A1 (en) 2009-10-07
CA2519705A1 (en) 2004-10-07
KR20060003868A (ko) 2006-01-11
US20060067898A1 (en) 2006-03-30
RU2005132390A (ru) 2006-06-27
CA2519705C (en) 2013-07-02
IS8078A (is) 2005-10-18
IL170963A (en) 2010-12-30
MXPA05010114A (es) 2006-04-27

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