BRPI0408653A - sìntese de ésteres de ácido 2-clorometil-6-metilbenzóico - Google Patents

sìntese de ésteres de ácido 2-clorometil-6-metilbenzóico

Info

Publication number
BRPI0408653A
BRPI0408653A BRPI0408653-8A BRPI0408653A BRPI0408653A BR PI0408653 A BRPI0408653 A BR PI0408653A BR PI0408653 A BRPI0408653 A BR PI0408653A BR PI0408653 A BRPI0408653 A BR PI0408653A
Authority
BR
Brazil
Prior art keywords
synthesis
chloromethyl
acid esters
methylbenzoic acid
alkyl
Prior art date
Application number
BRPI0408653-8A
Other languages
English (en)
Inventor
Claus-Juergen Maier
Tobias Metzenthin
Joachim Graeser
Richard Bicker
Javier Manero
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BRPI0408653A publication Critical patent/BRPI0408653A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"SìNTESE DE éSTERES DE áCIDO 2-CLOROMETIL-6-METILBENZóICO". A presente invenção refere-se a um processo para preparação de compostos de fórmula (I), na qual R, H, opcionalmente representam alquila substituída por halogênio, cicloalquila, arila, alquil-arila ou heteroarila e que podem ser substituídos, em alquila e cicloalquila, um ou mais grupos CH~ 2~- por -O-. Os compostos de fórmula (I) são produtos intermediários valiosos na síntese de agonistas PPAR.
BRPI0408653-8A 2003-03-25 2004-03-12 sìntese de ésteres de ácido 2-clorometil-6-metilbenzóico BRPI0408653A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10313228A DE10313228A1 (de) 2003-03-25 2003-03-25 Synthese von 2-Chlormethyl-6-methylbenzoesäureestern
PCT/EP2004/002579 WO2004085377A1 (de) 2003-03-25 2004-03-12 Synthese von 2-chlormethyl-6-methylbenzoesäureestern

Publications (1)

Publication Number Publication Date
BRPI0408653A true BRPI0408653A (pt) 2006-03-07

Family

ID=33015963

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408653-8A BRPI0408653A (pt) 2003-03-25 2004-03-12 sìntese de ésteres de ácido 2-clorometil-6-metilbenzóico

Country Status (24)

Country Link
EP (1) EP1611083B1 (pt)
JP (1) JP4510805B2 (pt)
KR (1) KR20050116388A (pt)
CN (1) CN100378065C (pt)
AR (1) AR043752A1 (pt)
AT (1) ATE374742T1 (pt)
AU (1) AU2004224177B2 (pt)
BR (1) BRPI0408653A (pt)
CA (1) CA2519715A1 (pt)
CO (1) CO5690546A2 (pt)
CY (1) CY1107029T1 (pt)
DE (2) DE10313228A1 (pt)
DK (1) DK1611083T3 (pt)
ES (1) ES2293237T3 (pt)
IL (1) IL171031A (pt)
MX (1) MXPA05010001A (pt)
NO (1) NO20054875L (pt)
NZ (1) NZ542603A (pt)
PL (1) PL1611083T3 (pt)
PT (1) PT1611083E (pt)
RU (1) RU2345982C2 (pt)
TW (1) TW200502213A (pt)
WO (1) WO2004085377A1 (pt)
ZA (1) ZA200506499B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005029382B3 (de) 2005-06-24 2006-12-21 Sanofi-Aventis Deutschland Gmbh Alkoxymethylyl-substituierte Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
CN114805120A (zh) * 2022-05-23 2022-07-29 江苏瑞达环保科技有限公司 一种间氰甲基苯甲酸甲酯的合成工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689425A (en) * 1986-11-06 1987-08-25 Stauffer Chemical Company Photochlorination of aromatic compounds in the side chain
WO1999018066A1 (en) * 1997-10-02 1999-04-15 Sankyo Company, Limited Amidocarboxylic acid derivatives
WO2000064876A1 (en) * 1999-04-28 2000-11-02 Aventis Pharma Deutschland Gmbh Tri-aryl acid derivatives as ppar receptor ligands
EP1177187B1 (en) * 1999-04-28 2007-07-25 Sanofi-Aventis Deutschland GmbH Di-aryl acid derivatives as ppar receptor ligands
JP4436129B2 (ja) * 2001-08-31 2010-03-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ジアリールシクロアルキル誘導体、その製造法及びｐｐａｒ−活性剤としてのその使用

Also Published As

Publication number Publication date
NZ542603A (en) 2007-12-21
CN100378065C (zh) 2008-04-02
HK1087098A1 (zh) 2006-10-06
PL1611083T3 (pl) 2008-01-31
AU2004224177A1 (en) 2004-10-07
PT1611083E (pt) 2007-11-26
AR043752A1 (es) 2005-08-10
RU2345982C2 (ru) 2009-02-10
ES2293237T3 (es) 2008-03-16
MXPA05010001A (es) 2005-11-17
DK1611083T3 (da) 2008-01-21
DE502004005137D1 (en) 2007-11-15
RU2005132827A (ru) 2006-02-10
NO20054875D0 (no) 2005-10-21
JP2006521307A (ja) 2006-09-21
NO20054875L (no) 2005-12-27
DE10313228A1 (de) 2004-10-21
TW200502213A (en) 2005-01-16
CA2519715A1 (en) 2004-10-07
ZA200506499B (en) 2006-07-26
KR20050116388A (ko) 2005-12-12
IL171031A (en) 2010-11-30
EP1611083B1 (de) 2007-10-03
JP4510805B2 (ja) 2010-07-28
WO2004085377A1 (de) 2004-10-07
CO5690546A2 (es) 2006-10-31
AU2004224177B2 (en) 2010-01-21
CN1759092A (zh) 2006-04-12
EP1611083A1 (de) 2006-01-04
ATE374742T1 (de) 2007-10-15
CY1107029T1 (el) 2012-09-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.