BRPI0408879A - compostos de pirrolo[1,2-b]piridazina e seus usos - Google Patents

compostos de pirrolo[1,2-b]piridazina e seus usos

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Publication number
BRPI0408879A
BRPI0408879A BRPI0408879-4A BRPI0408879A BRPI0408879A BR PI0408879 A BRPI0408879 A BR PI0408879A BR PI0408879 A BRPI0408879 A BR PI0408879A BR PI0408879 A BRPI0408879 A BR PI0408879A
Authority
BR
Brazil
Prior art keywords
crf
pyrrolo
stereoisomers
formula
pharmaceutically acceptable
Prior art date
Application number
BRPI0408879-4A
Other languages
English (en)
Inventor
Jian-Min Fu
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0408879A publication Critical patent/BRPI0408879A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
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Abstract

"COMPOSTOS DE PIRROLO¢1,2-B! PIRIDAZINA E SEUS USOS". Descreve-se inusitados antagonistas de receptores de CRF e seu uso no tratamento de uma série de distúrbios, incluindo os que manifestam hipersecreção de CRF ou associados a CRF ou receptores de CRF, tais como ansiedade e depressão. os antagonistas de receptores de CRF da invenção têm a estrutura de fórmula (I): incluindo seus estereoisómeros ou mistura de estereoisómeros, seus pró-medicamentos farmaceuticamente aceitáveis ou os seus sais farmaceuticamente aceitáveis, onde, na fórmula (I), R é H ou Me.
BRPI0408879-4A 2003-04-04 2004-03-22 compostos de pirrolo[1,2-b]piridazina e seus usos BRPI0408879A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46073403P 2003-04-04 2003-04-04
PCT/IB2004/000951 WO2004087709A1 (en) 2003-04-04 2004-03-22 Pyrrolo[1,2-b]pyridazine compounds and their uses

Publications (1)

Publication Number Publication Date
BRPI0408879A true BRPI0408879A (pt) 2006-04-11

Family

ID=33131931

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408879-4A BRPI0408879A (pt) 2003-04-04 2004-03-22 compostos de pirrolo[1,2-b]piridazina e seus usos

Country Status (7)

Country Link
US (1) US7056920B2 (pt)
EP (1) EP1613631A1 (pt)
JP (1) JP2006522094A (pt)
BR (1) BRPI0408879A (pt)
CA (1) CA2520899A1 (pt)
MX (1) MXPA05010667A (pt)
WO (1) WO2004087709A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006525309A (ja) * 2003-05-07 2006-11-09 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ピロロ（１，２−ｂ）ピリダジン化合物、ならびにＣＲＦ−１受容体拮抗薬としてのその使用
US20070224636A1 (en) * 2006-03-24 2007-09-27 Pfizer Inc Pyrrolo[1,2b]pyridazine compounds and their uses
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL332040A1 (en) 1996-08-28 1999-08-16 Pfizer Substitution 6,5-heterobicyclic derivatives
IL137019A0 (en) 1998-01-28 2001-06-14 Du Pont Pharm Co Azolo triazines and pyrimidines
KR20010034881A (ko) 1998-05-21 2001-04-25 시오노 요시히코 ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체
WO2002072101A1 (en) 2001-03-13 2002-09-19 Bristol-Myers Squibb Pharma Company A corticotropin releasing factor receptor ligand, its enantiomer and pharmaceutically acceptable salts
ES2282401T3 (es) 2001-03-13 2007-10-16 Bristol-Myers Squibb Pharma Company 4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
AR041470A1 (es) 2002-10-17 2005-05-18 Upjohn Co Compuestos de pirrolo (1,2 - b) piridazina y sus usos

Also Published As

Publication number Publication date
MXPA05010667A (es) 2005-12-12
JP2006522094A (ja) 2006-09-28
EP1613631A1 (en) 2006-01-11
CA2520899A1 (en) 2004-10-14
US20040204415A1 (en) 2004-10-14
WO2004087709A1 (en) 2004-10-14
US7056920B2 (en) 2006-06-06

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