BRPI0408843A - compostos de pirrolo[1,2-b]piridazina e seu uso como antagonistas dos receptores de crf1 - Google Patents

compostos de pirrolo[1,2-b]piridazina e seu uso como antagonistas dos receptores de crf1

Info

Publication number
BRPI0408843A
BRPI0408843A BRPI0408843-3A BRPI0408843A BRPI0408843A BR PI0408843 A BRPI0408843 A BR PI0408843A BR PI0408843 A BRPI0408843 A BR PI0408843A BR PI0408843 A BRPI0408843 A BR PI0408843A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
crf
pyrrolo
pyridazine compounds
crf1 receptor
Prior art date
Application number
BRPI0408843-3A
Other languages
English (en)
Inventor
Jian-Min Fu
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0408843A publication Critical patent/BRPI0408843A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
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  • Hospice & Palliative Care (AREA)
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Abstract

"COMPOSTOS DE PIRROLO¢1,2-B!PIRIDAZINA E SEU USO COMO ANTAGONISTAS DOS RECEPTORES DE CRF1". Descreve-se inusitados antagonistas de receptores de CRF e seu uso no tratamento de uma série de distúrbios, incluindo os que manifestam hipersecreção de CRF ou associados a CRF ou receptores de CRF, tais como ansiedade e depressão. Os antagonistas de receptores de CRF da invenção têm a estrutura de fórmula (I) incluindo seus estereoisómeros ou mistura de estereoisómeros, seus pró-medicamentos farmaceuticamente aceitáveis ou os seus sais farmaceuticamente aceitáveis, onde, na fórmula (I), R é H ou Me.
BRPI0408843-3A 2003-04-02 2004-03-22 compostos de pirrolo[1,2-b]piridazina e seu uso como antagonistas dos receptores de crf1 BRPI0408843A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45974403P 2003-04-02 2003-04-02
PCT/IB2004/000971 WO2004087710A1 (en) 2003-04-02 2004-03-22 Pyrrolo`1,2-b!pyridazine compounds and their use as crf1 receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0408843A true BRPI0408843A (pt) 2006-04-04

Family

ID=33131904

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408843-3A BRPI0408843A (pt) 2003-04-02 2004-03-22 compostos de pirrolo[1,2-b]piridazina e seu uso como antagonistas dos receptores de crf1

Country Status (7)

Country Link
US (1) US7041671B2 (pt)
EP (1) EP1613630A1 (pt)
JP (1) JP2006522095A (pt)
BR (1) BRPI0408843A (pt)
CA (1) CA2520900A1 (pt)
MX (1) MXPA05010620A (pt)
WO (1) WO2004087710A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006525309A (ja) * 2003-05-07 2006-11-09 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ピロロ（１，２−ｂ）ピリダジン化合物、ならびにＣＲＦ−１受容体拮抗薬としてのその使用
US20060148807A1 (en) * 2004-03-12 2006-07-06 Pfizer Inc Pyrrolo[1,2b]pyridazine compounds and their uses
PH12012500778A1 (en) * 2009-10-30 2012-11-26 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
AU2012247564B2 (en) * 2011-04-28 2016-05-26 Janssen Pharmaceutica Nv Salt of an inhibitor of phosphodiesterase 10 enzyme
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
AU2013289284B2 (en) 2012-07-09 2017-03-30 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
PL332040A1 (en) 1996-08-28 1999-08-16 Pfizer Substitution 6,5-heterobicyclic derivatives
US6081118A (en) * 1998-04-07 2000-06-27 Kaplan; Jerome I. Rapid high-accuracy magnetic resonance imaging
KR20010034881A (ko) 1998-05-21 2001-04-25 시오노 요시히코 ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체
WO2002072101A1 (en) 2001-03-13 2002-09-19 Bristol-Myers Squibb Pharma Company A corticotropin releasing factor receptor ligand, its enantiomer and pharmaceutically acceptable salts
ES2282401T3 (es) 2001-03-13 2007-10-16 Bristol-Myers Squibb Pharma Company 4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
AR041470A1 (es) * 2002-10-17 2005-05-18 Upjohn Co Compuestos de pirrolo (1,2 - b) piridazina y sus usos

Also Published As

Publication number Publication date
MXPA05010620A (es) 2005-11-23
US7041671B2 (en) 2006-05-09
WO2004087710A1 (en) 2004-10-14
US20040204414A1 (en) 2004-10-14
CA2520900A1 (en) 2004-10-14
JP2006522095A (ja) 2006-09-28
EP1613630A1 (en) 2006-01-11

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