BRPI0408961A - método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente - Google Patents

método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente

Info

Publication number
BRPI0408961A
BRPI0408961A BRPI0408961-8A BRPI0408961A BRPI0408961A BR PI0408961 A BRPI0408961 A BR PI0408961A BR PI0408961 A BRPI0408961 A BR PI0408961A BR PI0408961 A BRPI0408961 A BR PI0408961A
Authority
BR
Brazil
Prior art keywords
patient
determining
condition
erbb
cancer
Prior art date
Application number
BRPI0408961-8A
Other languages
English (en)
Inventor
Po-Ying Chan-Hui
Hossein Salimi-Moosavi
Yining Shi
Sharat Singh
Rajiv Dua
Ali Mukher-Jee
Sailaja Pidaparthi
Original Assignee
Monogram Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/623,057 external-priority patent/US7105308B2/en
Application filed by Monogram Biosciences Inc filed Critical Monogram Biosciences Inc
Publication of BRPI0408961A publication Critical patent/BRPI0408961A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODO PARA DETERMINAR UMA SITUAçãO DE DOENçA DE UM PACIENTE, MéTODO PARA SELECIONAR UM PACIENTE PARA TRATAMENTO DE UM CáNCER COM UM OU MAIS MEDICAMENTOS DE AçãO DIMéRICA DE ERBB, E, MéTODO PARA DETERMINAR UMA SITUAçãO CANCEROSA DE UM PACIENTE". A invenção está direcionada a uma nova classe de biomarcador em amostras de paciente que compreende dímeros de receptores de membrana de superfície celular de ErbB. Em um aspecto, a invenção inclui um método para determinar uma situação de uma doença ou condição saudável correlacionando-se tal condição com as quantidades de um ou mais dímeros de receptores de membrana de superfície celular de ErbB medidas diretamente em uma amostra do paciente, em particular uma amostra de tecido fixa. Em um outro aspecto, a invenção inclui um método para determinar uma situação de um câncer em um espécime de um indivíduo correlacionando-se medições de quantidades de um ou mais dímeros de receptores de membrana de superfície celular de ErbB nas células do espécime para tal situação, incluindo a presença ou ausência de um estado pré canceroso, presença ou ausência de um estado canceroso, prognóstico de um câncer ou responsividade ao tratamento. Preferivelmente, os métodos da invenção são implementados usando-se conjuntos de compostos de ligação tendo rótulos moleculares liberáveis que são específicos para componentes múltiplos de um ou mais tipos de dímeros receptores. Depois da ligação, os rótulos moleculares são liberados e separados da mistura de ensaio para análise.
BRPI0408961-8A 2003-04-01 2004-03-30 método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente BRPI0408961A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US45988803P 2003-04-01 2003-04-01
US10/623,057 US7105308B2 (en) 2002-07-25 2003-07-17 Detecting receptor oligomerization
US49448203P 2003-08-11 2003-08-11
US50803403P 2003-10-01 2003-10-01
US51294103P 2003-10-20 2003-10-20
US52325803P 2003-11-18 2003-11-18
PCT/US2004/009715 WO2004091384A2 (en) 2003-04-01 2004-03-30 Erbb surface receptor complexes as biomarkers

Publications (1)

Publication Number Publication Date
BRPI0408961A true BRPI0408961A (pt) 2006-10-31

Family

ID=33136354

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0408950-2A BRPI0408950A (pt) 2003-04-01 2004-03-30 método para determinar a situação de doença de um paciente, e, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica
BRPI0408961-8A BRPI0408961A (pt) 2003-04-01 2004-03-30 método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente
BRPI0408928-6A BRPI0408928A (pt) 2003-04-01 2004-03-30 métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0408950-2A BRPI0408950A (pt) 2003-04-01 2004-03-30 método para determinar a situação de doença de um paciente, e, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0408928-6A BRPI0408928A (pt) 2003-04-01 2004-03-30 métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente

Country Status (6)

Country Link
EP (3) EP1613732A4 (pt)
JP (2) JP2006521821A (pt)
AU (3) AU2004225439A1 (pt)
BR (3) BRPI0408950A (pt)
CA (3) CA2521082A1 (pt)
WO (3) WO2004087887A2 (pt)

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Also Published As

Publication number Publication date
AU2004225439A1 (en) 2004-10-14
EP1613205B1 (en) 2013-04-24
WO2004087887A2 (en) 2004-10-14
AU2004230700A1 (en) 2004-10-28
CA2521106A1 (en) 2004-10-14
JP2006523314A (ja) 2006-10-12
WO2004091384A3 (en) 2005-12-29
EP1613961A4 (en) 2007-03-07
AU2004229348A1 (en) 2004-10-28
WO2004092353A3 (en) 2005-03-03
WO2004092353A2 (en) 2004-10-28
EP1613961A2 (en) 2006-01-11
WO2004087887A3 (en) 2006-06-15
BRPI0408928A (pt) 2006-09-12
CA2521077A1 (en) 2004-10-28
EP1613732A2 (en) 2006-01-11
EP1613205A2 (en) 2006-01-11
CA2521082A1 (en) 2004-10-28
WO2004091384A2 (en) 2004-10-28
BRPI0408950A (pt) 2006-03-28
EP1613732A4 (en) 2012-03-14
JP2006521821A (ja) 2006-09-28
EP1613205A4 (en) 2006-11-29

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