BRPI0413471A - métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica - Google Patents

métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica

Info

Publication number
BRPI0413471A
BRPI0413471A BRPI0413471-0A BRPI0413471A BRPI0413471A BR PI0413471 A BRPI0413471 A BR PI0413471A BR PI0413471 A BRPI0413471 A BR PI0413471A BR PI0413471 A BRPI0413471 A BR PI0413471A
Authority
BR
Brazil
Prior art keywords
complex
detecting
methods
biological sample
protein complexes
Prior art date
Application number
BRPI0413471-0A
Other languages
English (en)
Inventor
Po-Ying Chan-Hui
Sharat Singh
Hossein Salimi-Moosavi
Uining Shi
Ali Mukherjee
Sailaja Pidaparthi
Rajiv Dua
Original Assignee
Monogram Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monogram Biosciences Inc filed Critical Monogram Biosciences Inc
Publication of BRPI0413471A publication Critical patent/BRPI0413471A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"MéTODOS PARA DETECTAR UM OU MAIS COMPLEXOS DE PROTEìNAS E PARA DETECTAR UM COMPLEXO EM UMA AMOSTRA BIOLóGICA". São proporcionados métodos para detectar a formação de complexos de moléculas, especialmente de proteínas, em uma amostra, tal como um lisado de tecido ou célula. Em um aspecto, são proporcionados uma sonda de clivagem específica para uma primeira proteína em um complexo e um ou mais compostos ligantes específicos para uma ou mais segundas proteínas em um complexo. Sob ligação, a sonda de clivagem é induzida para gerar uma espécie ativa, tal como oxigênio singleto, que cliva marcadores moleculares ligados nos compostos ligantes apenas em uma região local da sonda de clivagem. Os marcadores moleculares liberados são separados da mistura de ensaio e um dos outros para proporcionar uma leitura que está relacionada com o número e com os tipos de proteínas presentes no complexo.
BRPI0413471-0A 2003-08-11 2004-08-10 métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica BRPI0413471A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49448203P 2003-08-11 2003-08-11
US50803403P 2003-10-01 2003-10-01
US51294103P 2003-10-20 2003-10-20
PCT/US2004/025945 WO2005019470A2 (en) 2003-08-11 2004-08-10 Detecting and profiling molecular complexes

Publications (1)

Publication Number Publication Date
BRPI0413471A true BRPI0413471A (pt) 2006-10-17

Family

ID=34222352

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413471-0A BRPI0413471A (pt) 2003-08-11 2004-08-10 métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica

Country Status (9)

Country Link
US (1) US8198031B2 (pt)
EP (1) EP1673399B1 (pt)
JP (1) JP2007502417A (pt)
AU (1) AU2004267420A1 (pt)
BR (1) BRPI0413471A (pt)
CA (1) CA2535510C (pt)
IL (1) IL173636A0 (pt)
NZ (1) NZ545873A (pt)
WO (1) WO2005019470A2 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US20100291594A1 (en) * 2003-07-17 2010-11-18 Laboratory Corporation Of America Holdings ErbB Surface Receptor Complexes as Biomarkers
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
FR2889700B1 (fr) * 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
MX344253B (es) * 2007-07-17 2016-12-09 Somalogic Inc Metodo para generar aptameros con constantes de disociacion mejoradas.
CA2706763C (en) 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
CA2711843C (en) 2007-12-20 2018-11-13 Laboratory Corporation Of America Holdings Her-2 diagnostic methods
US8470542B2 (en) * 2008-12-01 2013-06-25 Laboratory Corporation Of America Holdings Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95
SG172983A1 (en) 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-3
BRPI1007048A2 (pt) * 2009-01-15 2016-02-10 Lab Corp America Holdings método e kit para correlacionar os níveis relativos da quantidade de pelo menos um de her-2 ou homodímeros de her-2 em uma amostra biológica de um indivíduo, e , método para prognosticar se um indivíduo com câncer e que é tratado com um agente que atua em her-2 é provável ter um evento significante.
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
EP2971064B1 (en) * 2013-03-12 2019-10-16 Ventana Medical Systems, Inc. Proximity assay for in situ detection of targets
EP3004860A4 (en) 2013-05-28 2017-02-15 Fluidigm Canada Inc. Molecular cytometry
US9801880B2 (en) * 2013-12-02 2017-10-31 Bergenbio As Use of kinase inhibitors
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
JP2019515252A (ja) 2016-03-15 2019-06-06 ラボラトリー コーポレイション オブ アメリカ ホールディングス 細胞間のタンパク質相互作用を評価する方法
KR102264642B1 (ko) * 2016-10-31 2021-06-15 유니베르시태트 취리히 단백질 스크리닝 및 검출 방법
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
CN117607223B (zh) * 2024-01-22 2024-04-09 南昌航空大学 一种基于整体柱富集分离的自驱动微流控系统

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2153059A (en) 1936-02-26 1939-04-04 Gen Aniline Works Inc Chromable dyestuffs of the triarylmethane series and process of preparing them
US2242572A (en) 1939-06-21 1941-05-20 Gen Aniline & Film Corp Chromable dyestuffs of the triarylmethane series and a process of preparing them
US3932415A (en) 1972-04-17 1976-01-13 Eastman Kodak Company Pyrylium dyes having a fused rigidized nitrogen-containing ring
FR2431581A1 (fr) 1978-07-18 1980-02-15 Soum Rene Systeme d'assemblage de planchers
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4320558A (en) * 1980-05-08 1982-03-23 Teepak, Inc. Continuous shirring and spinning machine for casings
US4375407A (en) 1981-06-22 1983-03-01 The Franklin Institute High gradient magnetic separation device
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US4675300A (en) 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5597531A (en) 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
DE3821454A1 (de) 1987-06-24 1989-02-09 Hitachi Ltd Verfahren zur aufbereitung gebrauchter elektrophorese-gele fuer die wiederverwendung
US4997926A (en) * 1987-11-18 1991-03-05 Scripps Clinic And Research Foundation Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
JP2681061B2 (ja) 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
US4997928A (en) 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5698271A (en) 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5654442A (en) 1989-11-14 1997-08-05 The Perkin-Elmer Corporation 4,7-dichlorofluorescein dyes as molecular probes
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
WO1992008133A1 (en) 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
ES2094795T3 (es) 1990-11-02 1997-02-01 Ici Plc Ftalocianinas polisustituidas.
US5646001A (en) 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
JP2758730B2 (ja) 1991-04-25 1998-05-28 三菱電機株式会社 放電励起パルスレーザ発振装置
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
WO1993020236A1 (en) 1992-04-03 1993-10-14 Applied Biosystems, Inc. Probe composition and method
ES2113547T3 (es) 1992-07-31 1998-05-01 Behringwerke Ag Matrices quimioluminiscentes fotoactivables.
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5811098A (en) 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US5374527A (en) 1993-01-21 1994-12-20 Applied Biosystems, Inc. High resolution DNA sequencing method using low viscosity medium
US5324401A (en) 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
ES2135597T3 (es) 1993-09-03 1999-11-01 Dade Behring Marburg Gmbh Inmunoensayos fluorescentes de canalizacion del oxigeno.
WO1995016910A1 (en) 1993-12-17 1995-06-22 Perkin-Elmer Corporation Uncharged polymers for separation of biomolecules by capillary electrophoresis
US5543026A (en) 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments
DE4428851C2 (de) 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
US5705059A (en) 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
US5560811A (en) 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
US5756726A (en) 1995-06-02 1998-05-26 Pharmacyclics, Inc. Methods of producing singlet oxygen using compounds having improved functionalization
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US6045676A (en) 1996-08-26 2000-04-04 The Board Of Regents Of The University Of California Electrochemical detector integrated on microfabricated capilliary electrophoresis chips
US5763602A (en) 1996-10-01 1998-06-09 Li; Ying-Syi Methods of syntheses of phthalocyanine compounds
US6245937B1 (en) 1996-11-29 2001-06-12 Dupont Pharmaceuticals Research Laboratories, Inc. Liquid phase parallel synthesis of chemical libraries
US5856107A (en) 1997-02-04 1999-01-05 Trega Biosciences, Inc. Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
US5998224A (en) 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US5900130A (en) 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
BR9907852A (pt) 1998-02-12 2000-10-24 Immunivest Corp Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes
US6095661A (en) 1998-03-19 2000-08-01 Ppt Vision, Inc. Method and apparatus for an L.E.D. flashlight
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6001673A (en) 1999-02-11 1999-12-14 Ericsson Inc. Methods for packaging integrated circuit devices including cavities adjacent active regions
US6627400B1 (en) * 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US20040248150A1 (en) 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6682887B1 (en) 1999-04-30 2004-01-27 Aclara Biosciences, Inc. Detection using degradation of a tagged sequence
US20030092012A1 (en) 2001-11-09 2003-05-15 Ahmed Chenna Methods for detecting a plurality of analytes by chromatography
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US6649351B2 (en) 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US20030235832A1 (en) 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6142162A (en) 1999-06-18 2000-11-07 Odoreyes Technology, Inc. System and method for odorizing natural gas
US6162593A (en) * 1999-10-26 2000-12-19 Wyatt; Marion F. Diisopropylbenzene containing solvent and method of developing flexographic printing plates
US6372907B1 (en) 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
MY133839A (en) * 2000-03-14 2007-11-30 Shell Int Research Process for the carbonylation of pentenenitrile
US6346384B1 (en) 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US20030170734A1 (en) 2000-04-28 2003-09-11 Stephen Williams Multiplexed assays using electrophoretically separated molecular tags
US7537938B2 (en) 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US20040067498A1 (en) 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
WO2002012547A1 (en) 2000-08-08 2002-02-14 Aclara Biosciences, Inc. Multiplexed enzymatic assays
AU2002305658A1 (en) 2001-05-21 2002-12-03 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
JP2005505749A (ja) * 2001-05-21 2005-02-24 アクララ バイオサイエンシーズ， インコーポレイテッド タンパク質を分析するための方法および組成物
US7358052B2 (en) 2001-05-26 2008-04-15 Monogram Biosciences, Inc. Catalytic amplification of multiplexed assay signals
WO2003033741A1 (en) 2001-10-16 2003-04-24 Aclara Biosciences, Inc. Universal e-tag primer and probe compositions and methods
US7045311B2 (en) 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
JP2006509183A (ja) 2002-03-05 2006-03-16 アクララ バイオサイエンシーズ， インコーポレイテッド 膜結合増感剤を用いる多重分析
US20040229293A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US7105308B2 (en) * 2002-07-25 2006-09-12 Monogram Biosciences, Inc. Detecting receptor oligomerization
US20090111127A1 (en) 2002-05-21 2009-04-30 Monogram Biosciences Inc. Surface Receptor Complexes as Biomarkers
US20040229380A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229299A1 (en) 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040175765A1 (en) 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
EP2263691B1 (en) * 2002-07-15 2012-08-29 F.Hoffmann-La Roche Ag Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4)
CA2493671A1 (en) 2002-07-26 2004-02-05 Aclara Biosciences, Inc. Lipophilic electrophoretic probes
US20040091850A1 (en) 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
WO2004087887A2 (en) * 2003-04-01 2004-10-14 Monogram Biosciences, Inc. Intracellular complexes as biomarkers
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US7402399B2 (en) 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
CA2543830A1 (en) 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
WO2006044748A2 (en) 2004-10-15 2006-04-27 Monogram Biosciences, Inc. RESPONSE PREDICTORS FOR ErbB PATHWAY-SPECIFIC DRUGS
CA2706763C (en) 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample

Also Published As

Publication number Publication date
EP1673399A2 (en) 2006-06-28
JP2007502417A (ja) 2007-02-08
EP1673399B1 (en) 2017-04-05
US8198031B2 (en) 2012-06-12
IL173636A0 (en) 2006-07-05
WO2005019470A2 (en) 2005-03-03
CA2535510C (en) 2013-10-15
CA2535510A1 (en) 2005-03-03
US20080233602A1 (en) 2008-09-25
NZ545873A (en) 2009-05-31
AU2004267420A1 (en) 2005-03-03
EP1673399A4 (en) 2009-06-10
WO2005019470A3 (en) 2005-06-09

Similar Documents

Publication Publication Date Title
BRPI0413471A (pt) métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica
BRPI0408928A (pt) métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente
Maly et al. A mechanism-based cross-linker for the identification of kinase− substrate pairs
Koushik et al. PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis
Wang et al. Identification of in vivo disulfide conformation of TRPA1 ion channel
BR0115715A (pt) Análise de expressão de ácidos nucleìcos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata
WO2005010215A3 (en) Methods for identifying tolerance modulatory compounds and uses therefor
Garate et al. NAD (P) H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b
Meyers et al. Targeted protein degradation through recruitment of the CUL4 complex adaptor protein DDB1
Park et al. Label-free target identification in drug discovery via phenotypic screening
SE0000538L (sv) Metoder och kit för analytdetektion mha proximitets-probning
EP1994142A4 (en) METHOD AND COMPOSITIONS FOR FAST ISOLATION OF SMALL RNA MOLECULES
EP1687283A4 (en) FOR THE DETERMINATION OF FK506 PROCEDURE AND COMPOSITION
Wang et al. Sulfation of the human cytomegalovirus protein UL22A enhances binding to the chemokine RANTES
ATE556717T1 (de) Neutralisierung monoklonaler antikörper gegen mit schwerem akutem respirationssyndrom assoziiertem coronavirus
Hamajima et al. Site-selective synthetic acylation of a target protein in living cells promoted by a chemical catalyst/donor system
WO2004063334A8 (en) Molecular cardiotoxicology modeling
ATE487141T1 (de) Hemmung von gasc1
Jennings et al. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase
Heidary et al. A light‐activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay
BRPI0416270A (pt) método para detectar um analito em uma amostra, e, método e kit para detectar um anticorpo especìfico de uma amostra
Di Pisa et al. Maximizing output in RNA‐programmed peptidyl‐transfer reactions
Jänsch et al. Switching the switch: ligand induced disulfide formation in HDAC8
Mittal et al. Changes in the mesenteric lymph proteome induced by hemorrhagic shock
Zheng et al. Chemical probes to directly profile palmitoleoylation of proteins

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]