BRPI0408928A - métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente - Google Patents
métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um pacienteInfo
- Publication number
- BRPI0408928A BRPI0408928A BRPI0408928-6A BRPI0408928A BRPI0408928A BR PI0408928 A BRPI0408928 A BR PI0408928A BR PI0408928 A BRPI0408928 A BR PI0408928A BR PI0408928 A BRPI0408928 A BR PI0408928A
- Authority
- BR
- Brazil
- Prior art keywords
- situation
- patient
- apoptotic
- complexes
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODOS PARA DETERMINAR UMA SITUAçãO DE DOENçA EM UM PACIENTE, UMA SITUAçãO APOPTóTICA DE CéLULAS EM UMA AMOSTRA, E UMA SITUAçãO DE UM CáNCER EM UM PACIENTE". A invenção fornece um método para determinar uma situação de doença em um paciente medindo-se níveis de expressão de complexos intracelulares selecionados. Em um aspecto da invenção, a situação de ativação de trajetos apoptóticos em uma amostra do paciente é determinada medindo-se quantidades relativas de complexos de proteína-proteína que são característicos dos trajetos apoptóticos. Em particular, a invenção fornece um método para determinar a situação de ativação do trajeto apoptótico mitocondrial medindo-se simultaneamente quantidades relativas de complexos entre proteínas 14-3-3 e proteinas BAD por um lado e complexos de proteínas Bcl-2 e proteínas BAD por outro lado. Preferivelmente, os métodos da invenção são implementados usando-se conjuntos de compostos de ligação tendo rótulos moleculares liberáveis que são específicos para componentes múltiplos de um ou mais complexos formados dentro de trajetos apoptóticos. Depois da ligação, os rótulos moleculares são liberados e separados da mistura de ensaio para análise.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45988803P | 2003-04-01 | 2003-04-01 | |
| US10/623,057 US7105308B2 (en) | 2002-07-25 | 2003-07-17 | Detecting receptor oligomerization |
| US49448203P | 2003-08-11 | 2003-08-11 | |
| US50803403P | 2003-10-01 | 2003-10-01 | |
| US51294103P | 2003-10-20 | 2003-10-20 | |
| US52325803P | 2003-11-18 | 2003-11-18 | |
| PCT/US2004/009805 WO2004087887A2 (en) | 2003-04-01 | 2004-03-30 | Intracellular complexes as biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0408928A true BRPI0408928A (pt) | 2006-09-12 |
Family
ID=33136354
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408950-2A BRPI0408950A (pt) | 2003-04-01 | 2004-03-30 | método para determinar a situação de doença de um paciente, e, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica |
| BRPI0408961-8A BRPI0408961A (pt) | 2003-04-01 | 2004-03-30 | método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente |
| BRPI0408928-6A BRPI0408928A (pt) | 2003-04-01 | 2004-03-30 | métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408950-2A BRPI0408950A (pt) | 2003-04-01 | 2004-03-30 | método para determinar a situação de doença de um paciente, e, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica |
| BRPI0408961-8A BRPI0408961A (pt) | 2003-04-01 | 2004-03-30 | método para determinar uma situação de doença de um paciente, método para selecionar um paciente para tratamento de um cáncer com um ou mais medicamentos de ação dimérica de erbb, e, método para determinar uma situação cancerosa de um paciente |
Country Status (6)
| Country | Link |
|---|---|
| EP (3) | EP1613732A4 (pt) |
| JP (2) | JP2006521821A (pt) |
| AU (3) | AU2004225439A1 (pt) |
| BR (3) | BRPI0408950A (pt) |
| CA (3) | CA2521082A1 (pt) |
| WO (3) | WO2004087887A2 (pt) |
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| AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
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| EP1613732A4 (en) * | 2003-04-01 | 2012-03-14 | Monogram Biosciences Inc | INTRA-CELLULAR COMPLEXES AS BIOMARKERS |
| WO2005037071A2 (en) * | 2003-10-14 | 2005-04-28 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
-
2004
- 2004-03-30 EP EP20040758577 patent/EP1613732A4/en not_active Withdrawn
- 2004-03-30 BR BRPI0408950-2A patent/BRPI0408950A/pt not_active IP Right Cessation
- 2004-03-30 BR BRPI0408961-8A patent/BRPI0408961A/pt not_active IP Right Cessation
- 2004-03-30 JP JP2006509481A patent/JP2006521821A/ja active Pending
- 2004-03-30 BR BRPI0408928-6A patent/BRPI0408928A/pt not_active IP Right Cessation
- 2004-03-30 CA CA002521082A patent/CA2521082A1/en not_active Abandoned
- 2004-03-30 AU AU2004225439A patent/AU2004225439A1/en not_active Abandoned
- 2004-03-30 WO PCT/US2004/009805 patent/WO2004087887A2/en not_active Ceased
- 2004-03-30 CA CA002521106A patent/CA2521106A1/en not_active Abandoned
- 2004-03-30 EP EP04759065A patent/EP1613961A4/en not_active Withdrawn
- 2004-03-30 JP JP2006509479A patent/JP2006523314A/ja active Pending
- 2004-03-30 EP EP04759064.1A patent/EP1613205B1/en not_active Expired - Lifetime
- 2004-03-30 WO PCT/US2004/009715 patent/WO2004091384A2/en not_active Ceased
- 2004-03-30 AU AU2004230700A patent/AU2004230700A1/en not_active Abandoned
- 2004-03-30 AU AU2004229348A patent/AU2004229348A1/en not_active Abandoned
- 2004-03-30 CA CA002521077A patent/CA2521077A1/en not_active Abandoned
- 2004-03-30 WO PCT/US2004/009717 patent/WO2004092353A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004225439A1 (en) | 2004-10-14 |
| EP1613205B1 (en) | 2013-04-24 |
| WO2004087887A2 (en) | 2004-10-14 |
| AU2004230700A1 (en) | 2004-10-28 |
| CA2521106A1 (en) | 2004-10-14 |
| JP2006523314A (ja) | 2006-10-12 |
| WO2004091384A3 (en) | 2005-12-29 |
| EP1613961A4 (en) | 2007-03-07 |
| BRPI0408961A (pt) | 2006-10-31 |
| AU2004229348A1 (en) | 2004-10-28 |
| WO2004092353A3 (en) | 2005-03-03 |
| WO2004092353A2 (en) | 2004-10-28 |
| EP1613961A2 (en) | 2006-01-11 |
| WO2004087887A3 (en) | 2006-06-15 |
| CA2521077A1 (en) | 2004-10-28 |
| EP1613732A2 (en) | 2006-01-11 |
| EP1613205A2 (en) | 2006-01-11 |
| CA2521082A1 (en) | 2004-10-28 |
| WO2004091384A2 (en) | 2004-10-28 |
| BRPI0408950A (pt) | 2006-03-28 |
| EP1613732A4 (en) | 2012-03-14 |
| JP2006521821A (ja) | 2006-09-28 |
| EP1613205A4 (en) | 2006-11-29 |
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