BRPI0409302A - derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos - Google Patents

derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos

Info

Publication number
BRPI0409302A
BRPI0409302A BRPI0409302-0A BRPI0409302A BRPI0409302A BR PI0409302 A BRPI0409302 A BR PI0409302A BR PI0409302 A BRPI0409302 A BR PI0409302A BR PI0409302 A BRPI0409302 A BR PI0409302A
Authority
BR
Brazil
Prior art keywords
muscarinic receptor
preparation
pharmaceutical composition
composition containing
receptor antagonists
Prior art date
Application number
BRPI0409302-0A
Other languages
English (en)
Inventor
Mohammad Salman
Pakala Kumara Savithru Sarma
Sankaranarayanan Dharmarajan
Anita Chugh
Naresh Kumar
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2003/001367 external-priority patent/WO2004005252A1/en
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BRPI0409302A publication Critical patent/BRPI0409302A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"DERIVADOS AZABICICLO COMO ANTAGONISTAS DE RECEPTORES MUSCARìNICOS, MéTODO PARA SUA PREPARAçãO E COMPOSIçãO FARMACêUTICA CONTENDO OS MESMOS". A presente invenção refere-se a antagonistas de receptores muscarínicos de Fórmula (I) que são úteis, entre outros usos, para o tratamento de várias doenças dos sistemas respiratório, urinário e gastrointestinal mediados através de receptores muscarínicos. Especificamente, a invenção refere-se a derivados de compostos azabicíclicos que incluem, por exemplo, 6-substituído azabiciclo ¢3.1.0! hexanos, bem como composições farmacêuticas contendo tais compostos e métodos de tratamento de doenças mediadas por receptores muscarínicos.
BRPI0409302-0A 2003-04-11 2004-01-06 derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos BRPI0409302A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2003/001367 WO2004005252A1 (en) 2002-07-08 2003-04-11 Azabicyclo derivatives as muscarinic receptor antagonists
PCT/IB2004/000008 WO2004089900A1 (en) 2003-04-11 2004-01-06 Azabicyclo derivatives as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0409302A true BRPI0409302A (pt) 2006-04-11

Family

ID=33156169

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0409302-0A BRPI0409302A (pt) 2003-04-11 2004-01-06 derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
BRPI0409308-9A BRPI0409308A (pt) 2003-04-11 2004-01-07 derivados azabiciclo como antagonistas de receptores muscarìnicos, composição farmacêutica e processo para sua preparação

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0409308-9A BRPI0409308A (pt) 2003-04-11 2004-01-07 derivados azabiciclo como antagonistas de receptores muscarìnicos, composição farmacêutica e processo para sua preparação

Country Status (10)

Country Link
US (2) US20070021487A1 (pt)
EP (2) EP1626957A1 (pt)
JP (2) JP2006522787A (pt)
CN (2) CN100436414C (pt)
AU (2) AU2004228452A1 (pt)
BR (2) BRPI0409302A (pt)
CA (2) CA2522071A1 (pt)
EA (1) EA009387B1 (pt)
NZ (2) NZ542952A (pt)
WO (2) WO2004089900A1 (pt)

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DE60230683D1 (de) 2002-07-08 2009-02-12 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
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CN101838271A (zh) * 2003-10-14 2010-09-22 辉瑞产品公司 作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物
US20100035954A1 (en) * 2004-12-15 2010-02-11 Mohammad Salman Acid addition salts of muscarinic receptor antagonists
US20080319043A1 (en) * 2005-05-03 2008-12-25 Mohammad Salman 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists
EP1904446A2 (en) * 2005-07-11 2008-04-02 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
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RU2008119323A (ru) * 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
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Also Published As

Publication number Publication date
CN100436414C (zh) 2008-11-26
BRPI0409308A (pt) 2006-05-02
EP1620087A1 (en) 2006-02-01
CN1794985A (zh) 2006-06-28
NZ542951A (en) 2008-11-28
JP2006522787A (ja) 2006-10-05
CA2521989A1 (en) 2004-10-21
CA2522071A1 (en) 2004-10-21
US20060287380A1 (en) 2006-12-21
US7446123B2 (en) 2008-11-04
EA009387B1 (ru) 2007-12-28
WO2004089364A1 (en) 2004-10-21
NZ542952A (en) 2008-11-28
AU2004228452A2 (en) 2004-10-21
AU2004228452A1 (en) 2004-10-21
AU2004228760A1 (en) 2004-10-21
EA200501593A1 (ru) 2006-06-30
EP1626957A1 (en) 2006-02-22
US20070021487A1 (en) 2007-01-25
WO2004089900A1 (en) 2004-10-21
JP2006522788A (ja) 2006-10-05
CN1795176A (zh) 2006-06-28

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