BRPI0409381A - formulações farmacêuticas nasais e métodos de utilizar as mesmas - Google Patents

formulações farmacêuticas nasais e métodos de utilizar as mesmas

Info

Publication number
BRPI0409381A
BRPI0409381A BRPI0409381-0A BRPI0409381A BRPI0409381A BR PI0409381 A BRPI0409381 A BR PI0409381A BR PI0409381 A BRPI0409381 A BR PI0409381A BR PI0409381 A BRPI0409381 A BR PI0409381A
Authority
BR
Brazil
Prior art keywords
pharmaceutical formulations
drug substance
nasal pharmaceutical
formulations
methods
Prior art date
Application number
BRPI0409381-0A
Other languages
English (en)
Inventor
Imtiaz Chaudry
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0409381A publication Critical patent/BRPI0409381A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"FORMULAçõES FARMACêUTICAS NASAIS E MéTODOS DE UTILIZAR MESMAS". A presente invenção refere-se a formulações farmacêuticas nasais compreendendo uma substância de droga tendo um perfil específico de distribuição de tamanho de partícula. Tal perfil proporciona biodisponibilidade aumentada, eficácia aumentada ou efeito terapêutico prolongado da substância de droga, quando administrada de modo intranasal. As formulações da presente invenção podem compreender um ou mais corticosteróides tendo um perfil específico de distribuição de tamanho de partícula. Em uma modalidade preferida, o corticosteróide é a beclometasona, ou um derivado farmaceuticamente aceitável da mesma, para o tratamento de um ou mais sintomas de rinite. De preferência, a substância de droga é o dipropionato de beclometasona. As formulações aqui contidas podem ser proporcionadas como uma suspensão aquosa, adequada para a inalação através da via intranasal.
BRPI0409381-0A 2003-04-16 2004-03-29 formulações farmacêuticas nasais e métodos de utilizar as mesmas BRPI0409381A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/414,682 US9808471B2 (en) 2003-04-16 2003-04-16 Nasal pharmaceutical formulations and methods of using the same
PCT/EP2004/003314 WO2004091574A1 (en) 2003-04-16 2004-03-29 Nasal pharmaceutical formulations and methods of using the same

Publications (1)

Publication Number Publication Date
BRPI0409381A true BRPI0409381A (pt) 2006-04-18

Family

ID=33158745

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409381-0A BRPI0409381A (pt) 2003-04-16 2004-03-29 formulações farmacêuticas nasais e métodos de utilizar as mesmas

Country Status (14)

Country Link
US (3) US9808471B2 (pt)
EP (1) EP1613280B1 (pt)
JP (1) JP4680180B2 (pt)
KR (1) KR101312311B1 (pt)
CN (3) CN1805730A (pt)
AU (2) AU2004229147A1 (pt)
BR (1) BRPI0409381A (pt)
CA (1) CA2522292C (pt)
ES (1) ES2643077T3 (pt)
MX (1) MXPA05011107A (pt)
PL (2) PL208784B1 (pt)
RU (1) RU2380090C2 (pt)
WO (1) WO2004091574A1 (pt)
ZA (2) ZA200509240B (pt)

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Also Published As

Publication number Publication date
RU2380090C2 (ru) 2010-01-27
CN1774238B (zh) 2013-09-04
EP1613280B1 (en) 2017-07-12
CN1805730A (zh) 2006-07-19
AU2010203026A1 (en) 2010-08-05
CA2522292A1 (en) 2004-10-28
JP2006523630A (ja) 2006-10-19
PL377931A1 (pl) 2006-02-20
CN1774238A (zh) 2006-05-17
US20040208830A1 (en) 2004-10-21
WO2004091574A1 (en) 2004-10-28
CN102319209A (zh) 2012-01-18
JP4680180B2 (ja) 2011-05-11
PL208784B1 (pl) 2011-06-30
AU2004229147A1 (en) 2004-10-28
KR20060003010A (ko) 2006-01-09
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