BRPI0409413A - composição farmacêutica, uso de um ácido ou sal biliar não conjugado, e, métodos para intensificar a absorção de um princìpio macromolecular ativo em um pacinete e para tratar um paciente que esteja sofrendo de uma condição ou doença tratável - Google Patents
composição farmacêutica, uso de um ácido ou sal biliar não conjugado, e, métodos para intensificar a absorção de um princìpio macromolecular ativo em um pacinete e para tratar um paciente que esteja sofrendo de uma condição ou doença tratávelInfo
- Publication number
- BRPI0409413A BRPI0409413A BRPI0409413-1A BRPI0409413A BRPI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- pharmaceutical composition
- absorption
- treating
- methods
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000010521 absorption reaction Methods 0.000 title abstract 2
- 239000003613 bile acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003833 bile salt Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 239000000473 propyl gallate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0308734.3A GB0308734D0 (en) | 2003-04-15 | 2003-04-15 | Uptake of macromolecules |
| PCT/GB2004/001651 WO2004091667A1 (en) | 2003-04-15 | 2004-04-15 | Uptake of macromolecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0409413A true BRPI0409413A (pt) | 2006-04-25 |
| BRPI0409413B1 BRPI0409413B1 (pt) | 2017-05-02 |
| BRPI0409413B8 BRPI0409413B8 (pt) | 2021-05-25 |
Family
ID=9956848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409413A BRPI0409413B8 (pt) | 2003-04-15 | 2004-04-15 | composição farmacêutica, e, uso de um ácido ou sal biliar não conjugado |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8314058B2 (pt) |
| EP (1) | EP1613355B1 (pt) |
| JP (1) | JP5047611B2 (pt) |
| KR (1) | KR101135784B1 (pt) |
| CN (1) | CN100506280C (pt) |
| AU (1) | AU2004229217B2 (pt) |
| BR (1) | BRPI0409413B8 (pt) |
| CA (1) | CA2522146C (pt) |
| CY (1) | CY1113461T1 (pt) |
| DK (1) | DK1613355T3 (pt) |
| ES (1) | ES2394640T3 (pt) |
| GB (1) | GB0308734D0 (pt) |
| NZ (1) | NZ543172A (pt) |
| PL (1) | PL1613355T3 (pt) |
| PT (1) | PT1613355E (pt) |
| RU (1) | RU2349344C2 (pt) |
| SI (1) | SI1613355T1 (pt) |
| WO (1) | WO2004091667A1 (pt) |
| ZA (1) | ZA200508344B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0308732D0 (en) * | 2003-04-15 | 2003-05-21 | Axcess Ltd | Absorption enhancers |
| GB0308734D0 (en) | 2003-04-15 | 2003-05-21 | Axcess Ltd | Uptake of macromolecules |
| GB0603252D0 (en) * | 2006-02-17 | 2006-03-29 | Axcess Ltd | Dissolution aids for oral peptide delivery |
| WO2008132731A2 (en) * | 2007-04-26 | 2008-11-06 | Oramed Pharmaceuticals, Inc | Methods and compositions for rectal administration of insulin |
| RU2494755C2 (ru) | 2008-08-18 | 2013-10-10 | Интера Био Лтд. | Способы и композиции для перорального введения белков |
| GB0817969D0 (en) * | 2008-10-01 | 2008-11-05 | Axcess Ltd | Pharmaceutical composition |
| SI3677252T1 (sl) | 2012-03-19 | 2024-02-29 | Cidara Therapeutics, Inc. | Sheme odmerjanja za spojine iz razreda ehinokandinov |
| ES2540581T3 (es) | 2012-10-17 | 2015-07-10 | Methylation Sciences International Srl | Composiciones que comprenden S-adenosilmetionina y un éster de ácido gálico |
| CR20200185A (es) * | 2017-10-31 | 2020-06-19 | Medimmune Ltd | Administración oral de análogos del péptido glp-1 |
| KR20220131946A (ko) * | 2020-01-23 | 2022-09-29 | 액세스 (유케이) 리미티드 | 세포 흡수 |
| IL303023A (en) * | 2020-11-27 | 2023-07-01 | D& D Pharmatech Inc | An oral formulation of a biologically active substance conjugate linked to a biotin unit, a fatty acid unit or a combination thereof |
| WO2022157676A1 (en) * | 2021-01-22 | 2022-07-28 | Axcess (UK) Ltd | Edta and egta for use in preserving the integrity of therapeutic compounds |
| GB2625490A (en) * | 2021-01-27 | 2024-06-19 | D&D Pharmatech Inc | Pharmaceutical composition comprising large physiologically active substance and excipient |
| AU2022344774A1 (en) * | 2021-09-07 | 2024-03-14 | D&D Pharmatech Inc. | Pharmaceutical composition comprising large physiologically active substance and excipient |
| KR102412437B1 (ko) | 2022-03-10 | 2022-06-23 | 주식회사 보은기계 | 선택적 시공이 가능한 수로시스템 |
| AU2024274445A1 (en) | 2023-05-15 | 2025-11-27 | Bonafide Health, Llc | Sleep-improving compositions and methods of use |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB354184A (en) | 1929-04-30 | 1931-07-29 | Pharmagans Pharmaceutisches In | An improved process for the production of hormone preparations |
| US3996355A (en) | 1975-01-02 | 1976-12-07 | American Home Products Corporation | Permanent suspension pharmaceutical dosage form |
| JPS5257313A (en) | 1975-11-07 | 1977-05-11 | Yamanouchi Pharmaceut Co Ltd | Manufacture of micellar insuline emulsion preparations |
| JPS56138168A (en) | 1980-03-31 | 1981-10-28 | Teijin Ltd | Movel active vitamin d3 derivative composition |
| IL68769A (en) | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| JPS61267528A (ja) | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
| US4760059A (en) * | 1985-08-05 | 1988-07-26 | Hoffmann-La Roche Inc. | Rectal dosage form |
| IE59934B1 (en) | 1987-06-19 | 1994-05-04 | Elan Corp Plc | Liquid suspension for oral administration |
| US4789660A (en) | 1987-09-10 | 1988-12-06 | American Home Products Corporation | Insulin administration using methyl and propyl paraben |
| US5756450A (en) | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| IT1251685B (it) | 1991-10-11 | 1995-05-19 | Isf Spa | Composizioni farmaceutiche contenenti una calcitonina |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US5849704A (en) | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5849700A (en) | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| JPH05246846A (ja) | 1992-03-03 | 1993-09-24 | Taiyo Kagaku Co Ltd | 蛋白質の消化促進組成物 |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| GB9417524D0 (en) * | 1994-08-31 | 1994-10-19 | Cortecs Ltd | Pharmaceutical compositions |
| US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| CA2224227A1 (en) * | 1995-06-07 | 1996-12-19 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| AU1808897A (en) | 1995-12-13 | 1997-07-03 | Dullatur Limited | A calcitonin preparation |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
| GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
| US5912240A (en) | 1997-04-10 | 1999-06-15 | Loria; Roger M. | 5-androstene 3β, 17α diol as an inhibitor of tumor growth |
| KR100514963B1 (ko) * | 1997-07-11 | 2005-09-15 | 도레이 가부시끼가이샤 | 4,5-에폭시모르피난 유도체를 함유하는 안정한 의약품 조성물 |
| US6180666B1 (en) | 1997-09-05 | 2001-01-30 | Anmax, Inc. | Use of gallic acid esters to increase bioavailability of orally administered pharmaceutical compounds |
| US5962522A (en) | 1997-09-05 | 1999-10-05 | Avmax, Inc. | Propyl gallate to increase bioavailability of orally administered pharmaceutical compounds |
| JP2001525371A (ja) | 1997-12-05 | 2001-12-11 | イーライ・リリー・アンド・カンパニー | Glp−1製剤 |
| AU1071200A (en) * | 1998-10-19 | 2000-05-08 | Biotech Australia Pty Limited | Systems for oral delivery |
| US6342249B1 (en) | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| WO2001074169A1 (en) | 2000-03-31 | 2001-10-11 | Council Of Scientific And Industrial Research | Highly nutritius cereal based food |
| JP2003532691A (ja) | 2000-05-05 | 2003-11-05 | ノボ ノルディスク アクティーゼルスカブ | 重症疾患神経障害 |
| AU2001225459B2 (en) | 2000-09-18 | 2005-12-22 | Rpg Life Sciences Limited | Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities |
| GB2368792A (en) * | 2000-10-06 | 2002-05-15 | Roger Randal Charles New | Absorption enhancers |
| US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| US6951655B2 (en) | 2001-10-11 | 2005-10-04 | Imi Biomed, Inc. | Pro-micelle pharmaceutical compositions |
| US20030232078A1 (en) | 2001-12-19 | 2003-12-18 | Dong Liang C. | Formulation & dosage form for the controlled delivery of therapeutic agents |
| GB0206792D0 (en) | 2002-03-22 | 2002-05-01 | Leuven K U Res & Dev | Normoglycemia |
| GB0308732D0 (en) | 2003-04-15 | 2003-05-21 | Axcess Ltd | Absorption enhancers |
| GB0308734D0 (en) | 2003-04-15 | 2003-05-21 | Axcess Ltd | Uptake of macromolecules |
-
2003
- 2003-04-15 GB GBGB0308734.3A patent/GB0308734D0/en not_active Ceased
-
2004
- 2004-04-15 PL PL04727588T patent/PL1613355T3/pl unknown
- 2004-04-15 SI SI200431970T patent/SI1613355T1/sl unknown
- 2004-04-15 CA CA2522146A patent/CA2522146C/en not_active Expired - Lifetime
- 2004-04-15 US US10/553,169 patent/US8314058B2/en not_active Expired - Fee Related
- 2004-04-15 CN CNB200480016322XA patent/CN100506280C/zh not_active Expired - Lifetime
- 2004-04-15 EP EP04727588A patent/EP1613355B1/en not_active Expired - Lifetime
- 2004-04-15 PT PT47275888T patent/PT1613355E/pt unknown
- 2004-04-15 ES ES04727588T patent/ES2394640T3/es not_active Expired - Lifetime
- 2004-04-15 DK DK04727588.8T patent/DK1613355T3/da active
- 2004-04-15 WO PCT/GB2004/001651 patent/WO2004091667A1/en not_active Ceased
- 2004-04-15 JP JP2006506135A patent/JP5047611B2/ja not_active Expired - Lifetime
- 2004-04-15 AU AU2004229217A patent/AU2004229217B2/en not_active Expired
- 2004-04-15 KR KR1020057019654A patent/KR101135784B1/ko not_active Expired - Lifetime
- 2004-04-15 RU RU2005135428/15A patent/RU2349344C2/ru not_active IP Right Cessation
- 2004-04-15 BR BRPI0409413A patent/BRPI0409413B8/pt not_active IP Right Cessation
- 2004-04-15 NZ NZ543172A patent/NZ543172A/xx not_active IP Right Cessation
-
2005
- 2005-10-14 ZA ZA200508344A patent/ZA200508344B/en unknown
-
2012
- 2012-12-12 CY CY20121101212T patent/CY1113461T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006523663A (ja) | 2006-10-19 |
| JP5047611B2 (ja) | 2012-10-10 |
| CA2522146C (en) | 2012-06-12 |
| EP1613355B1 (en) | 2012-09-19 |
| CY1113461T1 (el) | 2016-06-22 |
| AU2004229217B2 (en) | 2010-03-25 |
| KR101135784B1 (ko) | 2012-04-16 |
| EP1613355A1 (en) | 2006-01-11 |
| BRPI0409413B1 (pt) | 2017-05-02 |
| ZA200508344B (en) | 2007-12-27 |
| US20060122097A1 (en) | 2006-06-08 |
| RU2005135428A (ru) | 2006-06-10 |
| CA2522146A1 (en) | 2005-10-13 |
| DK1613355T3 (da) | 2013-01-02 |
| PL1613355T3 (pl) | 2013-09-30 |
| HK1078277A1 (en) | 2006-03-10 |
| US8314058B2 (en) | 2012-11-20 |
| BRPI0409413B8 (pt) | 2021-05-25 |
| SI1613355T1 (sl) | 2013-01-31 |
| KR20060021293A (ko) | 2006-03-07 |
| PT1613355E (pt) | 2012-12-26 |
| CN100506280C (zh) | 2009-07-01 |
| WO2004091667A1 (en) | 2004-10-28 |
| AU2004229217A1 (en) | 2004-10-28 |
| GB0308734D0 (en) | 2003-05-21 |
| ES2394640T3 (es) | 2013-02-04 |
| CN1805759A (zh) | 2006-07-19 |
| RU2349344C2 (ru) | 2009-03-20 |
| NZ543172A (en) | 2009-05-31 |
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