BRPI0409413A - composição farmacêutica, uso de um ácido ou sal biliar não conjugado, e, métodos para intensificar a absorção de um princìpio macromolecular ativo em um pacinete e para tratar um paciente que esteja sofrendo de uma condição ou doença tratável - Google Patents

composição farmacêutica, uso de um ácido ou sal biliar não conjugado, e, métodos para intensificar a absorção de um princìpio macromolecular ativo em um pacinete e para tratar um paciente que esteja sofrendo de uma condição ou doença tratável

Info

Publication number
BRPI0409413A
BRPI0409413A BRPI0409413-1A BRPI0409413A BRPI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A
Authority
BR
Brazil
Prior art keywords
salt
pharmaceutical composition
absorption
treating
methods
Prior art date
Application number
BRPI0409413-1A
Other languages
English (en)
Inventor
Roger R C New
Original Assignee
Axcess Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcess Ltd filed Critical Axcess Ltd
Publication of BRPI0409413A publication Critical patent/BRPI0409413A/pt
Publication of BRPI0409413B1 publication Critical patent/BRPI0409413B1/pt
Publication of BRPI0409413B8 publication Critical patent/BRPI0409413B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1816Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH], i.e. somatotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA, USO DE UM áCIDO OU SAL BILIAR NãO CONJUGADO, E, MéTODOS PARA INTENSIFICAR A ABSORçãO DE UM PRINCìPIO MACROMOLECULAR ATIVO EM UM PACIENTE E PARA TRATAR UM PACIENTE QUE ESTEJA SOFRENDO DE UMA CONDIçãO OU DOENçA TRATáVEL". A invenção refere-se a uma composição farmacêutica compreendendo uma mistura de: (a) um princípio macromolecular ativo; e (b) um sal ou ácido biliar não conjugado; e um aditivo escolhido dentre galato de propila, butil hidróxi anisol (BHA) e seus análogos e derivados, ou misturas destes.
BRPI0409413A 2003-04-15 2004-04-15 composição farmacêutica, e, uso de um ácido ou sal biliar não conjugado BRPI0409413B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0308734.3A GB0308734D0 (en) 2003-04-15 2003-04-15 Uptake of macromolecules
PCT/GB2004/001651 WO2004091667A1 (en) 2003-04-15 2004-04-15 Uptake of macromolecules

Publications (3)

Publication Number Publication Date
BRPI0409413A true BRPI0409413A (pt) 2006-04-25
BRPI0409413B1 BRPI0409413B1 (pt) 2017-05-02
BRPI0409413B8 BRPI0409413B8 (pt) 2021-05-25

Family

ID=9956848

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409413A BRPI0409413B8 (pt) 2003-04-15 2004-04-15 composição farmacêutica, e, uso de um ácido ou sal biliar não conjugado

Country Status (19)

Country Link
US (1) US8314058B2 (pt)
EP (1) EP1613355B1 (pt)
JP (1) JP5047611B2 (pt)
KR (1) KR101135784B1 (pt)
CN (1) CN100506280C (pt)
AU (1) AU2004229217B2 (pt)
BR (1) BRPI0409413B8 (pt)
CA (1) CA2522146C (pt)
CY (1) CY1113461T1 (pt)
DK (1) DK1613355T3 (pt)
ES (1) ES2394640T3 (pt)
GB (1) GB0308734D0 (pt)
NZ (1) NZ543172A (pt)
PL (1) PL1613355T3 (pt)
PT (1) PT1613355E (pt)
RU (1) RU2349344C2 (pt)
SI (1) SI1613355T1 (pt)
WO (1) WO2004091667A1 (pt)
ZA (1) ZA200508344B (pt)

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GB0308732D0 (en) * 2003-04-15 2003-05-21 Axcess Ltd Absorption enhancers
GB0308734D0 (en) 2003-04-15 2003-05-21 Axcess Ltd Uptake of macromolecules
GB0603252D0 (en) * 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
WO2008132731A2 (en) * 2007-04-26 2008-11-06 Oramed Pharmaceuticals, Inc Methods and compositions for rectal administration of insulin
RU2494755C2 (ru) 2008-08-18 2013-10-10 Интера Био Лтд. Способы и композиции для перорального введения белков
GB0817969D0 (en) * 2008-10-01 2008-11-05 Axcess Ltd Pharmaceutical composition
SI3677252T1 (sl) 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
ES2540581T3 (es) 2012-10-17 2015-07-10 Methylation Sciences International Srl Composiciones que comprenden S-adenosilmetionina y un éster de ácido gálico
CR20200185A (es) * 2017-10-31 2020-06-19 Medimmune Ltd Administración oral de análogos del péptido glp-1
KR20220131946A (ko) * 2020-01-23 2022-09-29 액세스 (유케이) 리미티드 세포 흡수
IL303023A (en) * 2020-11-27 2023-07-01 D& D Pharmatech Inc An oral formulation of a biologically active substance conjugate linked to a biotin unit, a fatty acid unit or a combination thereof
WO2022157676A1 (en) * 2021-01-22 2022-07-28 Axcess (UK) Ltd Edta and egta for use in preserving the integrity of therapeutic compounds
GB2625490A (en) * 2021-01-27 2024-06-19 D&D Pharmatech Inc Pharmaceutical composition comprising large physiologically active substance and excipient
AU2022344774A1 (en) * 2021-09-07 2024-03-14 D&D Pharmatech Inc. Pharmaceutical composition comprising large physiologically active substance and excipient
KR102412437B1 (ko) 2022-03-10 2022-06-23 주식회사 보은기계 선택적 시공이 가능한 수로시스템
AU2024274445A1 (en) 2023-05-15 2025-11-27 Bonafide Health, Llc Sleep-improving compositions and methods of use

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Also Published As

Publication number Publication date
JP2006523663A (ja) 2006-10-19
JP5047611B2 (ja) 2012-10-10
CA2522146C (en) 2012-06-12
EP1613355B1 (en) 2012-09-19
CY1113461T1 (el) 2016-06-22
AU2004229217B2 (en) 2010-03-25
KR101135784B1 (ko) 2012-04-16
EP1613355A1 (en) 2006-01-11
BRPI0409413B1 (pt) 2017-05-02
ZA200508344B (en) 2007-12-27
US20060122097A1 (en) 2006-06-08
RU2005135428A (ru) 2006-06-10
CA2522146A1 (en) 2005-10-13
DK1613355T3 (da) 2013-01-02
PL1613355T3 (pl) 2013-09-30
HK1078277A1 (en) 2006-03-10
US8314058B2 (en) 2012-11-20
BRPI0409413B8 (pt) 2021-05-25
SI1613355T1 (sl) 2013-01-31
KR20060021293A (ko) 2006-03-07
PT1613355E (pt) 2012-12-26
CN100506280C (zh) 2009-07-01
WO2004091667A1 (en) 2004-10-28
AU2004229217A1 (en) 2004-10-28
GB0308734D0 (en) 2003-05-21
ES2394640T3 (es) 2013-02-04
CN1805759A (zh) 2006-07-19
RU2349344C2 (ru) 2009-03-20
NZ543172A (en) 2009-05-31

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B25G Requested change of headquarter approved

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/04/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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