BRPI0409413A - composição farmacêutica, uso de um ácido ou sal biliar não conjugado, e, métodos para intensificar a absorção de um princìpio macromolecular ativo em um pacinete e para tratar um paciente que esteja sofrendo de uma condição ou doença tratável - Google Patents

composição farmacêutica, uso de um ácido ou sal biliar não conjugado, e, métodos para intensificar a absorção de um princìpio macromolecular ativo em um pacinete e para tratar um paciente que esteja sofrendo de uma condição ou doença tratável

Info

Publication number
BRPI0409413A
BRPI0409413A BRPI0409413-1A BRPI0409413A BRPI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A BR PI0409413 A BRPI0409413 A BR PI0409413A
Authority
BR
Brazil
Prior art keywords
salt
pharmaceutical composition
absorption
treating
methods
Prior art date
Application number
BRPI0409413-1A
Other languages
English (en)
Inventor
Roger R C New
Original Assignee
Axcess Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcess Ltd filed Critical Axcess Ltd
Publication of BRPI0409413A publication Critical patent/BRPI0409413A/pt
Publication of BRPI0409413B1 publication Critical patent/BRPI0409413B1/pt
Publication of BRPI0409413B8 publication Critical patent/BRPI0409413B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA, USO DE UM áCIDO OU SAL BILIAR NãO CONJUGADO, E, MéTODOS PARA INTENSIFICAR A ABSORçãO DE UM PRINCìPIO MACROMOLECULAR ATIVO EM UM PACIENTE E PARA TRATAR UM PACIENTE QUE ESTEJA SOFRENDO DE UMA CONDIçãO OU DOENçA TRATáVEL". A invenção refere-se a uma composição farmacêutica compreendendo uma mistura de: (a) um princípio macromolecular ativo; e (b) um sal ou ácido biliar não conjugado; e um aditivo escolhido dentre galato de propila, butil hidróxi anisol (BHA) e seus análogos e derivados, ou misturas destes.
BRPI0409413A 2003-04-15 2004-04-15 composição farmacêutica, e, uso de um ácido ou sal biliar não conjugado BRPI0409413B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0308734.3A GB0308734D0 (en) 2003-04-15 2003-04-15 Uptake of macromolecules
PCT/GB2004/001651 WO2004091667A1 (en) 2003-04-15 2004-04-15 Uptake of macromolecules

Publications (3)

Publication Number Publication Date
BRPI0409413A true BRPI0409413A (pt) 2006-04-25
BRPI0409413B1 BRPI0409413B1 (pt) 2017-05-02
BRPI0409413B8 BRPI0409413B8 (pt) 2021-05-25

Family

ID=9956848

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409413A BRPI0409413B8 (pt) 2003-04-15 2004-04-15 composição farmacêutica, e, uso de um ácido ou sal biliar não conjugado

Country Status (19)

Country Link
US (1) US8314058B2 (pt)
EP (1) EP1613355B1 (pt)
JP (1) JP5047611B2 (pt)
KR (1) KR101135784B1 (pt)
CN (1) CN100506280C (pt)
AU (1) AU2004229217B2 (pt)
BR (1) BRPI0409413B8 (pt)
CA (1) CA2522146C (pt)
CY (1) CY1113461T1 (pt)
DK (1) DK1613355T3 (pt)
ES (1) ES2394640T3 (pt)
GB (1) GB0308734D0 (pt)
NZ (1) NZ543172A (pt)
PL (1) PL1613355T3 (pt)
PT (1) PT1613355E (pt)
RU (1) RU2349344C2 (pt)
SI (1) SI1613355T1 (pt)
WO (1) WO2004091667A1 (pt)
ZA (1) ZA200508344B (pt)

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GB0308732D0 (en) * 2003-04-15 2003-05-21 Axcess Ltd Absorption enhancers
GB0308734D0 (en) 2003-04-15 2003-05-21 Axcess Ltd Uptake of macromolecules
GB0603252D0 (en) * 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
WO2008132731A2 (en) * 2007-04-26 2008-11-06 Oramed Pharmaceuticals, Inc Methods and compositions for rectal administration of insulin
JP5740689B2 (ja) 2008-08-18 2015-06-24 エンテラ バイオ エルティーディー． タンパク質の経口投与用の方法および組成物
GB0817969D0 (en) * 2008-10-01 2008-11-05 Axcess Ltd Pharmaceutical composition
HRP20231151T1 (hr) 2012-03-19 2024-01-05 Cidara Therapeutics, Inc. Režimi za doziranje spojeva iz klase ehinokandina
EP2949331A1 (en) 2012-10-17 2015-12-02 Methylation Sciences International SRL Compositions comprising s-adenosylmethionine and a gallic acid ester
CN111655338A (zh) * 2017-10-31 2020-09-11 免疫医疗有限公司 Glp-1肽类似物的口服递送
CA3168207A1 (en) * 2020-01-23 2021-07-29 Axcess (Uk) Ltd. Cellular uptake
EP4252781A1 (en) * 2020-11-27 2023-10-04 D&D Pharmatech Inc. Oral formulation of biologically active material conjugate having biotin moiety, fatty acid moiety, or combination thereof coupled thereto
EP4281062A1 (en) * 2021-01-22 2023-11-29 AXCESS (UK) Ltd. Edta and egta for use in preserving the integrity of therapeutic compounds
GB2625490A (en) * 2021-01-27 2024-06-19 D&D Pharmatech Inc Pharmaceutical composition comprising large physiologically active substance and excipient
KR20230039783A (ko) * 2021-09-07 2023-03-21 ㈜ 디앤디파마텍 거대 생리활성 물질 및 부형제를 포함하는 약학 조성물
KR102412437B1 (ko) 2022-03-10 2022-06-23 주식회사 보은기계 선택적 시공이 가능한 수로시스템
EP4712796A2 (en) 2023-05-15 2026-03-25 Bonafide Health, LLC Sleep-improving compositions and methods of use

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Also Published As

Publication number Publication date
EP1613355A1 (en) 2006-01-11
RU2005135428A (ru) 2006-06-10
WO2004091667A1 (en) 2004-10-28
PL1613355T3 (pl) 2013-09-30
CA2522146A1 (en) 2005-10-13
ZA200508344B (en) 2007-12-27
RU2349344C2 (ru) 2009-03-20
CN100506280C (zh) 2009-07-01
CY1113461T1 (el) 2016-06-22
BRPI0409413B1 (pt) 2017-05-02
KR20060021293A (ko) 2006-03-07
CN1805759A (zh) 2006-07-19
HK1078277A1 (en) 2006-03-10
NZ543172A (en) 2009-05-31
PT1613355E (pt) 2012-12-26
CA2522146C (en) 2012-06-12
DK1613355T3 (da) 2013-01-02
US20060122097A1 (en) 2006-06-08
ES2394640T3 (es) 2013-02-04
JP2006523663A (ja) 2006-10-19
AU2004229217A1 (en) 2004-10-28
BRPI0409413B8 (pt) 2021-05-25
SI1613355T1 (sl) 2013-01-31
KR101135784B1 (ko) 2012-04-16
US8314058B2 (en) 2012-11-20
EP1613355B1 (en) 2012-09-19
JP5047611B2 (ja) 2012-10-10
GB0308734D0 (en) 2003-05-21
AU2004229217B2 (en) 2010-03-25

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