BRPI0410305A - composições de um inibidor seletivo de ciclooxigenase-2 á base de benzenossulfonamida ou metilsulfonilbenzeno e um agente colinérgico para o tratamento de redução de fluxo sangüìneo ou traumatismo do sistema nervoso central - Google Patents
composições de um inibidor seletivo de ciclooxigenase-2 á base de benzenossulfonamida ou metilsulfonilbenzeno e um agente colinérgico para o tratamento de redução de fluxo sangüìneo ou traumatismo do sistema nervoso centralInfo
- Publication number
- BRPI0410305A BRPI0410305A BRPI0410305-0A BRPI0410305A BRPI0410305A BR PI0410305 A BRPI0410305 A BR PI0410305A BR PI0410305 A BRPI0410305 A BR PI0410305A BR PI0410305 A BRPI0410305 A BR PI0410305A
- Authority
- BR
- Brazil
- Prior art keywords
- nervous system
- central nervous
- compositions
- treatment
- inhibitor
- Prior art date
Links
- 210000003169 central nervous system Anatomy 0.000 title abstract 4
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title abstract 3
- 208000001738 Nervous System Trauma Diseases 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 title abstract 3
- 230000001713 cholinergic effect Effects 0.000 title abstract 3
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 3
- JCDWETOKTFWTHA-UHFFFAOYSA-N methylsulfonylbenzene Chemical compound CS(=O)(=O)C1=CC=CC=C1 JCDWETOKTFWTHA-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 title abstract 2
- 230000017531 blood circulation Effects 0.000 title abstract 2
- 208000028412 nervous system injury Diseases 0.000 abstract 2
- 238000002648 combination therapy Methods 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSIçõES DE UM INIBIDOR SELETIVO DE CICLOOXIGENASE-2 à BASE DE BENZENOSSULFONAMIDA OU METILSULFONILBENZENO E UM AGENTE COLINéRGICO PARA O TRATAMENTO DE REDUçãO DE FLUXO SANGüìNEO OU TRAUMATISMO DO SISTEMA NERVOSO CENTRAL". A presente invenção refere-se a métodos e composições para o tratamento de lesão no sistema nervoso central em um indivíduo. Mais particularmente, a invenção providencia uma terapia de combinação para o tratamento de uma condição isquêmica do sistema nervoso central ou uma lesão traumática do sistema nervoso central, incluíndo a administração a um indivíduo de um agente colinérgico em combinação com um inibidor seletivo de ciclooxigenase-2 à base de benzenossulfonamida ou metilsulfonilbenzeno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47037303P | 2003-05-14 | 2003-05-14 | |
| PCT/US2004/014984 WO2004103284A2 (en) | 2003-05-14 | 2004-05-13 | Compositions of a benzenesulfonamide or methylsulfonylbenzene cyclooxygenase-2 selective inhibitor and a cholinergic agent for the treatment of reduced blood flow or trauma to the central nervous system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0410305A true BRPI0410305A (pt) | 2006-05-23 |
Family
ID=33476701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410305-0A BRPI0410305A (pt) | 2003-05-14 | 2004-05-13 | composições de um inibidor seletivo de ciclooxigenase-2 á base de benzenossulfonamida ou metilsulfonilbenzeno e um agente colinérgico para o tratamento de redução de fluxo sangüìneo ou traumatismo do sistema nervoso central |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050159471A1 (pt) |
| EP (1) | EP1628653A2 (pt) |
| JP (1) | JP2006528695A (pt) |
| BR (1) | BRPI0410305A (pt) |
| CA (1) | CA2525571A1 (pt) |
| MX (1) | MXPA05012280A (pt) |
| WO (1) | WO2004103284A2 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201602145D0 (en) | 2016-02-05 | 2016-03-23 | Achieve Pharma Uk Ltd | Salt |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06214699A (ja) * | 1993-01-14 | 1994-08-05 | Toshiba Corp | キーボード装置 |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| GEP20032998B (en) * | 1996-04-12 | 2003-06-25 | Searle & Co | Substituted Benzenesulfonamide Derivatives as Prodrugs of Cox-2 Inhibitors |
| IL138686A0 (en) * | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
-
2004
- 2004-05-13 CA CA002525571A patent/CA2525571A1/en not_active Abandoned
- 2004-05-13 EP EP04752099A patent/EP1628653A2/en not_active Withdrawn
- 2004-05-13 MX MXPA05012280A patent/MXPA05012280A/es not_active Application Discontinuation
- 2004-05-13 BR BRPI0410305-0A patent/BRPI0410305A/pt not_active IP Right Cessation
- 2004-05-13 US US10/845,574 patent/US20050159471A1/en not_active Abandoned
- 2004-05-13 JP JP2006533027A patent/JP2006528695A/ja not_active Withdrawn
- 2004-05-13 WO PCT/US2004/014984 patent/WO2004103284A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1628653A2 (en) | 2006-03-01 |
| JP2006528695A (ja) | 2006-12-21 |
| WO2004103284A2 (en) | 2004-12-02 |
| CA2525571A1 (en) | 2004-12-02 |
| WO2004103284A3 (en) | 2005-11-10 |
| US20050159471A1 (en) | 2005-07-21 |
| MXPA05012280A (es) | 2006-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A , 5A , 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |