BRPI0411126A - derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno - Google Patents

derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno

Info

Publication number
BRPI0411126A
BRPI0411126A BRPI0411126-5A BRPI0411126A BRPI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A
Authority
BR
Brazil
Prior art keywords
compounds
phenalene
triaza
treatment
control
Prior art date
Application number
BRPI0411126-5A
Other languages
English (en)
Inventor
Kin-Chun Luk
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0411126A publication Critical patent/BRPI0411126A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

"DERIVADOS DE 1,3,4-TRIAZA-FENALENO E 1,3,4,6-TETRAAZAFENALENO". A presente invenção refere-se a novos derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno da fórmula (I). Estes compostos inibem a tirosina cinase de receptor de fator de crescimento epidérmico ('EGFR'). Estes compostos e seus ésteres e sais farmaceuticamente aceitáveis têm atividade antiproliferativa e são úteis, entre outros, no tratamento ou controle de câncer, em particular tumores sólidos. Esta invenção da mesma forma se refere a composições farmacêuticas que contêm tais compostos e aos métodos de tratar ou controlar câncer, mais particularmente o tratamento ou controle de tumores de mama, pulmão, cólon e próstata.
BRPI0411126-5A 2003-06-10 2004-04-26 derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno BRPI0411126A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47731803P 2003-06-10 2003-06-10
PCT/EP2004/050608 WO2004111055A1 (en) 2003-06-10 2004-04-26 1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives

Publications (1)

Publication Number Publication Date
BRPI0411126A true BRPI0411126A (pt) 2006-07-18

Family

ID=33551702

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411126-5A BRPI0411126A (pt) 2003-06-10 2004-04-26 derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno

Country Status (15)

Country Link
US (1) US7217717B2 (pt)
EP (1) EP1680426B1 (pt)
JP (1) JP2006527235A (pt)
KR (1) KR100753385B1 (pt)
CN (1) CN100378101C (pt)
AT (1) ATE373661T1 (pt)
AU (1) AU2004247418B2 (pt)
BR (1) BRPI0411126A (pt)
CA (1) CA2527832A1 (pt)
DE (1) DE602004009097T2 (pt)
ES (1) ES2293251T3 (pt)
MX (1) MXPA05013145A (pt)
PL (1) PL1680426T3 (pt)
RU (1) RU2346946C2 (pt)
WO (1) WO2004111055A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2209375T3 (da) * 2007-10-03 2014-10-06 Eisai Inc Parp-inhibitorforbindelser, præparater og fremgangsmåder til anvendelse deraf
RU2393162C2 (ru) * 2008-09-12 2010-06-27 Государственное образовательное учреждение высшего профессионального образования САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ ХИМИКО-ФАРМАЦЕВТИЧЕСКАЯ АКАДЕМИЯ (ГОУ ВПО СПХФА Росздрава) ЗАМЕЩЕННЫЕ 2Н,8Н-1,4-ДИОКСА-9b-АЗАФЕНАЛЕН-2,8-ДИОНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
RU2498986C2 (ru) * 2011-07-20 2013-11-20 Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
CN104945406B (zh) * 2015-05-25 2017-10-10 苏州康润医药有限公司 氮杂非那烯‑3‑酮的衍生物、其制备方法及其作为parp抑制剂的应用
CN115894486B (zh) * 2021-09-30 2024-02-09 北京赛特明强医药科技有限公司 一种氢化吡啶并喹唑啉类化合物、组合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
DE69332567T2 (de) * 1992-09-11 2003-04-17 The Regents Of The University Of California, Oakland Inhibitoren von metazoan-parasit-proteasen
US5739170A (en) * 1992-09-11 1998-04-14 The Regents Of The University Of California Inhibitors of metazoan parasite proteases
MX9707453A (es) 1995-03-30 1997-12-31 Pfizer Derivados de quinazolina.
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
TW436485B (en) * 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
TR200003166T2 (tr) 1998-04-29 2001-02-21 Osi Pharmaceuticals, Inc. N-(3-etinilfenilamino)-6, 7-bis(2-metoksietoksi)-4-kuinozolamin mesilat anhidrat ve monohidrat.
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
KR20030060927A (ko) * 2000-11-03 2003-07-16 뉴로크린 바이오사이언시즈 인코퍼레이티드 Ｃｒｆ 수용체 길항제 및 이와 관련된 방법
EP2173338A1 (en) * 2007-07-06 2010-04-14 OSI Pharmaceuticals, Inc. Combination anti-cancer therapy

Also Published As

Publication number Publication date
AU2004247418A1 (en) 2004-12-23
KR20060017854A (ko) 2006-02-27
KR100753385B1 (ko) 2007-08-30
DE602004009097T2 (de) 2008-06-19
CN100378101C (zh) 2008-04-02
US20040254205A1 (en) 2004-12-16
RU2346946C2 (ru) 2009-02-20
CA2527832A1 (en) 2004-12-23
DE602004009097D1 (de) 2007-10-31
EP1680426A1 (en) 2006-07-19
CN1805964A (zh) 2006-07-19
WO2004111055A1 (en) 2004-12-23
AU2004247418B2 (en) 2009-11-05
RU2006100034A (ru) 2006-08-27
US7217717B2 (en) 2007-05-15
ES2293251T3 (es) 2008-03-16
MXPA05013145A (es) 2006-03-17
ATE373661T1 (de) 2007-10-15
PL1680426T3 (pl) 2008-02-29
JP2006527235A (ja) 2006-11-30
EP1680426B1 (en) 2007-09-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.