BRPI0511975A - pirazolopirimidinas - Google Patents

pirazolopirimidinas

Info

Publication number
BRPI0511975A
BRPI0511975A BRPI0511975-8A BRPI0511975A BRPI0511975A BR PI0511975 A BRPI0511975 A BR PI0511975A BR PI0511975 A BRPI0511975 A BR PI0511975A BR PI0511975 A BRPI0511975 A BR PI0511975A
Authority
BR
Brazil
Prior art keywords
cyclin
pyrazolopyrimidines
dependent kinase
treatment
control
Prior art date
Application number
BRPI0511975-8A
Other languages
English (en)
Inventor
Qingjie Ding
Nan Jiang
John Lawson Roberts
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0511975A publication Critical patent/BRPI0511975A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PIRAZOLOPIRIMIDINAS. A invenção refere-se a novas pirazolopirimidinas de fórmula (I). Estas pirazolopirimidinas são capazes de inibir a atividade das cinases dependentes da ciclina, mais particularmente a cinase 1 dependente da ciclina (Cdkl), cinase 2 dependente da ciclina (Cdk2), e cinase 4 dependente da ciclina (Cdk4) e são assim úteis, inter alia, no tratamento ou controle de câncer, em particular tumores sólidos. Esta invenção também refere-se a composições farmacêuticas contendo tais compostos e aos métodos de tratamento ou controle de câncer, mais particularmente o tratamento ou controle de tumores da mama, pulmão, cólon e próstata.
BRPI0511975-8A 2004-06-09 2005-06-01 pirazolopirimidinas BRPI0511975A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57825304P 2004-06-09 2004-06-09
PCT/EP2005/005896 WO2005121107A1 (en) 2004-06-09 2005-06-01 Pyrazolo pyrimidines

Publications (1)

Publication Number Publication Date
BRPI0511975A true BRPI0511975A (pt) 2008-01-22

Family

ID=35170008

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511975-8A BRPI0511975A (pt) 2004-06-09 2005-06-01 pirazolopirimidinas

Country Status (14)

Country Link
US (1) US7405220B2 (pt)
EP (1) EP1758871B1 (pt)
JP (1) JP2008501744A (pt)
CN (1) CN1964954B (pt)
AT (1) ATE378321T1 (pt)
AU (1) AU2005251892A1 (pt)
BR (1) BRPI0511975A (pt)
CA (1) CA2568722A1 (pt)
DE (1) DE602005003362T2 (pt)
ES (1) ES2296195T3 (pt)
MX (1) MXPA06014161A (pt)
PL (1) PL1758871T3 (pt)
RU (1) RU2412186C2 (pt)
WO (1) WO2005121107A1 (pt)

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CN102690270B (zh) * 2012-05-28 2014-02-05 苏州科捷生物医药有限公司 嘧啶类化合物及其用途
CN103058934A (zh) * 2013-01-07 2013-04-24 盛世泰科生物医药技术(苏州)有限公司 一种5-乙酰基-2,4-二氯嘧啶的合成方法
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ES2754803T3 (es) * 2015-01-23 2020-04-20 Glaxosmithkline Ip Dev Ltd Derivado de pirazolo[3,4-dpirimidina y su uso para el tratamiento de leishmaniasis
DE102016110830B4 (de) 2015-06-14 2022-01-13 Zema - Zentrum Für Mechatronik Und Automatisierungstechnik Gemeinnützige Gmbh Vorrichtung zur Befestigung einer Adaptionsplatte an einer Radnabe eines Fahrzeugs und Verfahren zum Betrieb einer Adaptionsplatte an einer Radnabe eines Fahrzeugs
CA3098988A1 (en) 2018-05-02 2019-11-07 Jw Pharmaceutical Corporation Heterocycle derivative
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
WO2021030537A1 (en) 2019-08-14 2021-02-18 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
CR20220170A (es) * 2019-10-11 2022-10-10 Incyte Corp Aminas bicíclicas como inhibidoras de la cdk2
JPWO2021141041A1 (pt) 2020-01-07 2021-07-15
CA3217792A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc Cdk2 degraders and uses thereof
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US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
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Also Published As

Publication number Publication date
DE602005003362T2 (de) 2008-10-16
US7405220B2 (en) 2008-07-29
ES2296195T3 (es) 2008-04-16
CA2568722A1 (en) 2005-12-22
WO2005121107A1 (en) 2005-12-22
EP1758871B1 (en) 2007-11-14
JP2008501744A (ja) 2008-01-24
ATE378321T1 (de) 2007-11-15
CN1964954A (zh) 2007-05-16
DE602005003362D1 (en) 2007-12-27
RU2007100134A (ru) 2008-07-20
MXPA06014161A (es) 2007-01-29
PL1758871T3 (pl) 2008-04-30
EP1758871A1 (en) 2007-03-07
RU2412186C2 (ru) 2011-02-20
AU2005251892A1 (en) 2005-12-22
CN1964954B (zh) 2010-07-21
US20050277655A1 (en) 2005-12-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.