BRPI0409366A - compostos de pirimido - Google Patents

compostos de pirimido

Info

Publication number
BRPI0409366A
BRPI0409366A BRPI0409366-6A BRPI0409366A BRPI0409366A BR PI0409366 A BRPI0409366 A BR PI0409366A BR PI0409366 A BRPI0409366 A BR PI0409366A BR PI0409366 A BRPI0409366 A BR PI0409366A
Authority
BR
Brazil
Prior art keywords
compounds
pyrimidine compounds
kdr
colon
lung
Prior art date
Application number
BRPI0409366-6A
Other languages
English (en)
Inventor
Yi Chen
Apostolos Dermatakis
Jin-Jun Liu
Kin-Chun Luk
Christophe Michoud
Pamela Loreen Rossman
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0409366A publication Critical patent/BRPI0409366A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS DE PIRIMIDO". A presente invenção refere-se a novos compostos de pirimido da fórmula: que são inibidores seletivos das cinases KDR e FGFR. Esses compostos e seus sais farmaceuticamente aceitáveis são agentes antiproliferativos usados no tratamento ou controle de tumores sólidos, em particular, tumores de mama, cólon, pulmão e próstata. Também descritas são composições farmacêuticas contendo esses compostos e o uso para tratamento de câncer.
BRPI0409366-6A 2003-04-10 2004-04-01 compostos de pirimido BRPI0409366A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46169403P 2003-04-10 2003-04-10
PCT/EP2004/003447 WO2004089955A1 (en) 2003-04-10 2004-04-01 Pyrimido compounds

Publications (1)

Publication Number Publication Date
BRPI0409366A true BRPI0409366A (pt) 2006-04-25

Family

ID=33159829

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409366-6A BRPI0409366A (pt) 2003-04-10 2004-04-01 compostos de pirimido

Country Status (11)

Country Link
US (1) US7115740B2 (pt)
EP (1) EP1615928A1 (pt)
JP (1) JP2006522756A (pt)
KR (2) KR20050111636A (pt)
CN (1) CN100497339C (pt)
AU (1) AU2004228155A1 (pt)
BR (1) BRPI0409366A (pt)
CA (1) CA2521124A1 (pt)
MX (1) MXPA05010765A (pt)
RU (1) RU2350617C2 (pt)
WO (1) WO2004089955A1 (pt)

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KR102344105B1 (ko) 2014-08-18 2021-12-29 에자이 알앤드디 매니지먼트 가부시키가이샤 모노시클릭 피리딘 유도체의 염 및 이의 결정
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
TWI712601B (zh) 2015-02-20 2020-12-11 美商英塞特公司 作為fgfr抑制劑之雙環雜環
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EP3275442B1 (en) 2015-03-25 2021-07-28 National Cancer Center Therapeutic agent for bile duct cancer
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CN109836427B (zh) * 2017-11-29 2022-04-15 暨南大学 嘧啶并嘧啶酮类化合物及其应用
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Also Published As

Publication number Publication date
KR20050111636A (ko) 2005-11-25
RU2005134686A (ru) 2006-07-27
RU2350617C2 (ru) 2009-03-27
CA2521124A1 (en) 2004-10-21
WO2004089955A1 (en) 2004-10-21
EP1615928A1 (en) 2006-01-18
KR20070087053A (ko) 2007-08-27
US20040204427A1 (en) 2004-10-14
CN100497339C (zh) 2009-06-10
MXPA05010765A (es) 2005-12-12
AU2004228155A1 (en) 2004-10-21
JP2006522756A (ja) 2006-10-05
CN1809569A (zh) 2006-07-26
US7115740B2 (en) 2006-10-03
KR100864393B1 (ko) 2008-10-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.