BRPI0411752A - implantes subcutáneos apresentando liberação inicial limitada do princìpio ativo e liberação ampliada subseqüente linearmente variável do mesmo - Google Patents

implantes subcutáneos apresentando liberação inicial limitada do princìpio ativo e liberação ampliada subseqüente linearmente variável do mesmo

Info

Publication number
BRPI0411752A
BRPI0411752A BRPI0411752-2A BRPI0411752A BRPI0411752A BR PI0411752 A BRPI0411752 A BR PI0411752A BR PI0411752 A BRPI0411752 A BR PI0411752A BR PI0411752 A BRPI0411752 A BR PI0411752A
Authority
BR
Brazil
Prior art keywords
active principle
initial release
subcutaneous implants
limited initial
linearly variable
Prior art date
Application number
BRPI0411752-2A
Other languages
English (en)
Inventor
Patrice Mauriac
Pierre Marion
Original Assignee
Mediolanum Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT001299A external-priority patent/ITMI20031299A1/it
Priority claimed from IT001301A external-priority patent/ITMI20031301A1/it
Priority claimed from IT001300A external-priority patent/ITMI20031300A1/it
Priority claimed from IT001303A external-priority patent/ITMI20031303A1/it
Application filed by Mediolanum Pharmaceuticals Ltd filed Critical Mediolanum Pharmaceuticals Ltd
Publication of BRPI0411752A publication Critical patent/BRPI0411752A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

"IMPLANTES SUBCUTáNEOS APRESENTANDO LIBERAçãO INICIAL LIMITADA DO PRINCìPIO ATIVO E LIBERAçãO AMPLIADA SUBSEQüENTE LINEARMENTE VARIáVEL DO MESMO". A presente invenção se refere a um implante subcutâneo que apresenta uma liberação inicial limitada do princípio ativo e uma liberação ampliada subseqüente linearmente variável do mesmo que consiste em um núcleo (i) que compreende um princípio ativo disperso em uma matriz polimérica de um copolímero de ácido poli láctico/glicólico (PLGA), um revestimento (ii) na forma de uma película que compreende como componente principal, um copolímero do ácido láctico-glicólico e os processos relacionados para preparar o referido implante.
BRPI0411752-2A 2003-06-26 2004-06-24 implantes subcutáneos apresentando liberação inicial limitada do princìpio ativo e liberação ampliada subseqüente linearmente variável do mesmo BRPI0411752A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT001299A ITMI20031299A1 (it) 2003-06-26 2003-06-26 Impianti sottocutanei aventi un rilascio iniziale limitato del principio attivo ed un successivo rilascio del medesimo in maniera estesa con andamento lineare.
IT001301A ITMI20031301A1 (it) 2003-06-26 2003-06-26 Impianti sottocutanei contenenti un principio attivo in grado di aumentare la densita' ossea in associazione con acido polilattico-glicolico per il trattamento dell'osteoporosi.
IT001300A ITMI20031300A1 (it) 2003-06-26 2003-06-26 Impianti sottocutanei contenenti principi attivi ad attivita' analgesica narcotica.
IT001303A ITMI20031303A1 (it) 2003-06-26 2003-06-26 Composizioni per impianti sottocutanei contenenti almeno un ormone steroideo per la terapia ormonale sostitutiva e per la contraccezione.
PCT/EP2004/051230 WO2005000278A1 (en) 2003-06-26 2004-06-24 Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof

Publications (1)

Publication Number Publication Date
BRPI0411752A true BRPI0411752A (pt) 2006-08-08

Family

ID=33556509

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411752-2A BRPI0411752A (pt) 2003-06-26 2004-06-24 implantes subcutáneos apresentando liberação inicial limitada do princìpio ativo e liberação ampliada subseqüente linearmente variável do mesmo

Country Status (16)

Country Link
US (1) US20070116738A1 (pt)
EP (1) EP1638535B1 (pt)
JP (1) JP2009513493A (pt)
KR (1) KR20060027353A (pt)
CN (1) CN100592904C (pt)
AT (1) ATE367803T1 (pt)
AU (1) AU2004251457B2 (pt)
BR (1) BRPI0411752A (pt)
CA (1) CA2530120A1 (pt)
CY (1) CY1106943T1 (pt)
DE (1) DE602004007802T2 (pt)
ES (1) ES2291893T3 (pt)
MX (1) MXPA05013698A (pt)
PL (1) PL1638535T3 (pt)
PT (1) PT1638535E (pt)
WO (1) WO2005000278A1 (pt)

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WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US8946277B2 (en) * 2008-04-18 2015-02-03 Warsaw Orthopedic, Inc. Clonidine formulations in a biodegradable polymer carrier
US9610243B2 (en) 2008-04-18 2017-04-04 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US9125917B2 (en) * 2008-04-18 2015-09-08 Warsaw Orthopedic, Inc. Fluocinolone formulations in a biodegradable polymer carrier
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US9289409B2 (en) * 2008-04-18 2016-03-22 Warsaw Orthopedic, Inc. Sulindac formulations in a biodegradable material
US9132085B2 (en) 2008-04-18 2015-09-15 Warsaw Orthopedic, Inc. Compositions and methods for treating post-operative pain using clonidine and bupivacaine
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
EP2246063A1 (en) * 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
KR20120107070A (ko) * 2009-09-22 2012-09-28 에보닉 데구사 코포레이션 다양한 생리활성 물질 로딩 구성을 갖는 임플란트 장치
JP2013505113A (ja) * 2009-09-22 2013-02-14 エボニック デグサ コーポレイション 生物活性剤の放出プロファイルを調節するためのインプラントデバイス
EP2866837B1 (en) * 2012-06-27 2022-12-14 Medincell S.A. Biodegradable drug delivery for hydrophobic compositions
US20160022570A1 (en) 2014-07-25 2016-01-28 Robert W. Adams Medical implant
CN214181164U (zh) * 2020-04-23 2021-09-14 克林维尔制药有限公司 药物植入物装置及多部分套件
CN116392450B (zh) * 2022-09-07 2025-07-01 江苏集萃新型药物制剂技术研究所有限公司 含雌激素的皮下植入物及其制备方法
CN116139090B (zh) * 2022-09-07 2025-07-01 江苏集萃新型药物制剂技术研究所有限公司 含雄激素的皮下植入物及其制备方法

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Also Published As

Publication number Publication date
PL1638535T3 (pl) 2007-12-31
CN100592904C (zh) 2010-03-03
DE602004007802D1 (de) 2007-09-06
KR20060027353A (ko) 2006-03-27
AU2004251457A1 (en) 2005-01-06
CY1106943T1 (el) 2012-09-26
DE602004007802T2 (de) 2008-04-17
EP1638535A1 (en) 2006-03-29
WO2005000278A1 (en) 2005-01-06
JP2009513493A (ja) 2009-04-02
HK1087031A1 (en) 2006-10-06
CN1812771A (zh) 2006-08-02
CA2530120A1 (en) 2005-01-06
ATE367803T1 (de) 2007-08-15
US20070116738A1 (en) 2007-05-24
EP1638535B1 (en) 2007-07-25
AU2004251457B2 (en) 2010-09-23
ES2291893T3 (es) 2008-03-01
MXPA05013698A (es) 2006-05-17
PT1638535E (pt) 2007-11-08

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.