BRPI0411769A - processo para a produção de melagatran - Google Patents
processo para a produção de melagatranInfo
- Publication number
- BRPI0411769A BRPI0411769A BRPI0411769-7A BRPI0411769A BRPI0411769A BR PI0411769 A BRPI0411769 A BR PI0411769A BR PI0411769 A BRPI0411769 A BR PI0411769A BR PI0411769 A BRPI0411769 A BR PI0411769A
- Authority
- BR
- Brazil
- Prior art keywords
- melagatran
- production
- formula
- compound
- vivo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- DKWNMCUOEDMMIN-PKOBYXMFSA-N melagatran Chemical compound C1=CC(C(=N)N)=CC=C1CNC(=O)[C@H]1N(C(=O)[C@H](NCC(O)=O)C2CCCCC2)CC1 DKWNMCUOEDMMIN-PKOBYXMFSA-N 0.000 title abstract 3
- 229960002137 melagatran Drugs 0.000 title abstract 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PROCESSO PARA A PRODUçãO DE MELAGATRAN". é apresentado um processo para a produção de melagatran, fórmula (I) ex vivo, cujo processo compreende a hidrólise de um composto da fórmula II, onde R é C~ 1-6~ alquila ou um grupo benzílico, para formar, na forma substancialmente isenta de sal, um composto intermediário da fórmula II, seguido pela redução daquele intermediário.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0301879A SE0301879D0 (sv) | 2003-06-25 | 2003-06-25 | New process |
| PCT/SE2004/001016 WO2004113364A1 (en) | 2003-06-25 | 2004-06-23 | New process for the production of melagatran |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411769A true BRPI0411769A (pt) | 2006-08-08 |
Family
ID=27656614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411769-7A BRPI0411769A (pt) | 2003-06-25 | 2004-06-23 | processo para a produção de melagatran |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060178312A1 (pt) |
| EP (1) | EP1641814A1 (pt) |
| JP (1) | JP2007536197A (pt) |
| KR (1) | KR20060025569A (pt) |
| CN (1) | CN1809585A (pt) |
| AU (1) | AU2004249658B2 (pt) |
| BR (1) | BRPI0411769A (pt) |
| CA (1) | CA2528930A1 (pt) |
| IL (1) | IL172287A0 (pt) |
| MX (1) | MXPA05013944A (pt) |
| NO (1) | NO20055925L (pt) |
| SE (1) | SE0301879D0 (pt) |
| WO (1) | WO2004113364A1 (pt) |
| ZA (1) | ZA200510102B (pt) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
-
2003
- 2003-06-25 SE SE0301879A patent/SE0301879D0/xx unknown
-
2004
- 2004-06-23 JP JP2006517053A patent/JP2007536197A/ja active Pending
- 2004-06-23 CN CNA2004800175458A patent/CN1809585A/zh active Pending
- 2004-06-23 BR BRPI0411769-7A patent/BRPI0411769A/pt not_active IP Right Cessation
- 2004-06-23 WO PCT/SE2004/001016 patent/WO2004113364A1/en not_active Ceased
- 2004-06-23 AU AU2004249658A patent/AU2004249658B2/en not_active Ceased
- 2004-06-23 MX MXPA05013944A patent/MXPA05013944A/es unknown
- 2004-06-23 CA CA002528930A patent/CA2528930A1/en not_active Abandoned
- 2004-06-23 KR KR1020057024865A patent/KR20060025569A/ko not_active Withdrawn
- 2004-06-23 EP EP04749054A patent/EP1641814A1/en not_active Withdrawn
- 2004-06-23 US US10/561,944 patent/US20060178312A1/en not_active Abandoned
-
2005
- 2005-11-30 IL IL172287A patent/IL172287A0/en unknown
- 2005-12-12 ZA ZA200510102A patent/ZA200510102B/xx unknown
- 2005-12-13 NO NO20055925A patent/NO20055925L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004249658B2 (en) | 2007-02-01 |
| KR20060025569A (ko) | 2006-03-21 |
| ZA200510102B (en) | 2006-11-29 |
| JP2007536197A (ja) | 2007-12-13 |
| IL172287A0 (en) | 2006-04-10 |
| NO20055925L (no) | 2006-01-19 |
| AU2004249658A1 (en) | 2004-12-29 |
| MXPA05013944A (es) | 2006-02-24 |
| US20060178312A1 (en) | 2006-08-10 |
| WO2004113364A1 (en) | 2004-12-29 |
| SE0301879D0 (sv) | 2003-06-25 |
| CA2528930A1 (en) | 2004-12-29 |
| CN1809585A (zh) | 2006-07-26 |
| EP1641814A1 (en) | 2006-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |