BRPI0412158A - derivados de imidazol iii - Google Patents
derivados de imidazol iiiInfo
- Publication number
- BRPI0412158A BRPI0412158A BRPI0412158-9A BRPI0412158A BRPI0412158A BR PI0412158 A BRPI0412158 A BR PI0412158A BR PI0412158 A BRPI0412158 A BR PI0412158A BR PI0412158 A BRPI0412158 A BR PI0412158A
- Authority
- BR
- Brazil
- Prior art keywords
- imidazole derivatives
- treatment
- relates
- derivatives iii
- chronic
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 3
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 1
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE IMIDAZOL III". A presente invenção refere-se a derivados de imidazol da fórmula geral (I), em que R¬ 1¬, R¬ 2¬, R¬ 3¬ e R¬ 4¬ são como definidos no relatório descritivo bem como sais farmaceuticamente aceitáveis e processos para a preparação dos mesmos. A invenção também se refere a medicamentos contendo os referidos derivados de imidazol e ao seu uso para a produção de medicamentos para o tratamento e a prevenção de distúrbios mediados por receptores de mGluR5 tais como distúrbios neurológicos agudos e/ou crónicos, em particular ansiedade, ou para o tratamento de dor crónica e aguda.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03014512 | 2003-07-03 | ||
| PCT/EP2004/007177 WO2005003117A1 (en) | 2003-07-03 | 2004-07-01 | Imidazole derivatives iii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0412158A true BRPI0412158A (pt) | 2006-08-22 |
Family
ID=33560749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0412158-9A BRPI0412158A (pt) | 2003-07-03 | 2004-07-01 | derivados de imidazol iii |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7091222B2 (pt) |
| EP (1) | EP1644351B1 (pt) |
| JP (1) | JP4571631B2 (pt) |
| KR (1) | KR100719653B1 (pt) |
| CN (1) | CN100562520C (pt) |
| AR (1) | AR044973A1 (pt) |
| AT (1) | ATE388145T1 (pt) |
| AU (1) | AU2004253657B2 (pt) |
| BR (1) | BRPI0412158A (pt) |
| CA (1) | CA2531210C (pt) |
| CO (1) | CO5660258A2 (pt) |
| DE (1) | DE602004012268T2 (pt) |
| DK (1) | DK1644351T3 (pt) |
| ES (1) | ES2300789T3 (pt) |
| HR (1) | HRP20080173T3 (pt) |
| IL (1) | IL172821A (pt) |
| MX (1) | MXPA06000193A (pt) |
| MY (1) | MY142085A (pt) |
| NO (1) | NO20060112L (pt) |
| NZ (1) | NZ544454A (pt) |
| PL (1) | PL1644351T3 (pt) |
| PT (1) | PT1644351E (pt) |
| RU (1) | RU2360911C2 (pt) |
| SI (1) | SI1644351T1 (pt) |
| TW (1) | TWI252849B (pt) |
| WO (1) | WO2005003117A1 (pt) |
| ZA (1) | ZA200600026B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7452909B2 (en) * | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
| HRP20080363T3 (hr) * | 2004-06-01 | 2008-09-30 | F. Hoffmann - La Roche Ag | Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora |
| PL1756086T3 (pl) * | 2004-06-01 | 2008-11-28 | Hoffmann La Roche | Pirydyn-4-ylo-etynylo-imidazole i pirazole jako antagoniści receptora mGlu5 |
| US20060173048A1 (en) * | 2005-02-03 | 2006-08-03 | Mcarthur Silvia G | Imidazole derivatives |
| DE102005062987A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| MY148217A (en) * | 2006-12-21 | 2013-03-29 | Hoffmann La Roche | Polymorphs of a mglur5 receptor antagonist |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US304910A (en) * | 1884-09-09 | Robeet h | ||
| US4882343A (en) * | 1987-08-28 | 1989-11-21 | G. D. Searle & Co. | Biarylalkylimidazole derivatives as anti-depressants |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| US7531529B2 (en) * | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
-
2004
- 2004-06-23 US US10/874,948 patent/US7091222B2/en not_active Expired - Fee Related
- 2004-07-01 CA CA2531210A patent/CA2531210C/en not_active Expired - Fee Related
- 2004-07-01 NZ NZ544454A patent/NZ544454A/en unknown
- 2004-07-01 MX MXPA06000193A patent/MXPA06000193A/es active IP Right Grant
- 2004-07-01 BR BRPI0412158-9A patent/BRPI0412158A/pt not_active IP Right Cessation
- 2004-07-01 AU AU2004253657A patent/AU2004253657B2/en not_active Ceased
- 2004-07-01 JP JP2006518089A patent/JP4571631B2/ja not_active Expired - Fee Related
- 2004-07-01 DK DK04740542T patent/DK1644351T3/da active
- 2004-07-01 SI SI200430679T patent/SI1644351T1/sl unknown
- 2004-07-01 TW TW093119915A patent/TWI252849B/zh not_active IP Right Cessation
- 2004-07-01 EP EP04740542A patent/EP1644351B1/en not_active Expired - Lifetime
- 2004-07-01 AT AT04740542T patent/ATE388145T1/de active
- 2004-07-01 HR HR20080173T patent/HRP20080173T3/xx unknown
- 2004-07-01 DE DE602004012268T patent/DE602004012268T2/de not_active Expired - Lifetime
- 2004-07-01 AR ARP040102312A patent/AR044973A1/es unknown
- 2004-07-01 RU RU2006103009/04A patent/RU2360911C2/ru not_active IP Right Cessation
- 2004-07-01 KR KR1020067000075A patent/KR100719653B1/ko not_active Expired - Fee Related
- 2004-07-01 CN CNB2004800200680A patent/CN100562520C/zh not_active Expired - Fee Related
- 2004-07-01 ES ES04740542T patent/ES2300789T3/es not_active Expired - Lifetime
- 2004-07-01 PL PL04740542T patent/PL1644351T3/pl unknown
- 2004-07-01 WO PCT/EP2004/007177 patent/WO2005003117A1/en not_active Ceased
- 2004-07-01 PT PT04740542T patent/PT1644351E/pt unknown
- 2004-07-02 MY MYPI20042649A patent/MY142085A/en unknown
-
2005
- 2005-12-26 IL IL172821A patent/IL172821A/en not_active IP Right Cessation
- 2005-12-29 CO CO05131363A patent/CO5660258A2/es not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600026A patent/ZA200600026B/en unknown
- 2006-01-06 NO NO20060112A patent/NO20060112L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0412291A (pt) | antagonistas duplos de nka/nk3 para o tratamento de esquizofrenia | |
| BR0112586A (pt) | Derivados de tetrahidro-heterocicloaze pirimidina | |
| BRPI0410563A (pt) | derivados de pirazol-quinazolina processo para sua preparação e seu uso como inibidores de quinase | |
| BR0315988A (pt) | Derivados de diidropirimido[4,5-d]pirimidinona substituìda por amino, sua produção e uso como agentes farmacêuticos | |
| WO2006067445A3 (en) | Csf-1r kinase inhibitors | |
| WO2007113558A3 (en) | Quinazolinone derivatives having b-raf inhibitory activity | |
| BR0308232A (pt) | Inibidores de cinase p38 de piridina e pirimidina bicìclicas | |
| BR0208387A (pt) | Derivados de imidazo (1,2-a)-piridina como antagonista de mglur5 | |
| DE60140814D1 (de) | N-phenyl-2-pyrimidine-amine derivatives | |
| BR0312722A (pt) | Derivados de pirazol heterobicìclico como inibidores de qinase | |
| BRPI0414330A (pt) | composto, processo para preparação do mesmo, métodos para produção de um efeito antibacteriano, para inibição de dna girase bacteriana, e para tratamento de uma infecção bacteriana em um animal de sangue quente, uso de um composto, e, composição farmacêutica | |
| SE0402735D0 (sv) | Novel compounds | |
| BR0314393A (pt) | Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia | |
| BRPI0606313A2 (pt) | derivados de 4-(1h-indol-3-il)-pirimidin-2-ilamina, processo para sua preparação e seu uso em terapia | |
| BR0307291A (pt) | Composto; processo para a preparação de um composto; composição farmacêutica; uso de um composto; método para o tratamento e profilaxia de distúrbios diversos e de obesidade em um humano | |
| BR0315665A (pt) | Antagonistas de cgrp selecionados, processos para preparação dos mesmos, bem como uso dos mesmos como medicamento | |
| ATE514699T1 (de) | Substituierte pyrrolopyrazolderivate als kinaseinhibitoren | |
| BRPI0411868A (pt) | derivados de pirrol[3,4-c]pirazol ativos como inibidores de cinase | |
| BRPI0514310A (pt) | 8-aminoalcóxi-xantinas substituìdas, método para a produção das mesmas e seu uso como medicamentos | |
| BRPI0408744A (pt) | 4-feniltetrahidroisoquinolinas substituìdas, processos para preparação das mesmas, seu uso como medicamento, bem como medicamento que contém as mesmas | |
| BRPI0411095B8 (pt) | derivados de imidazol, seus usos e seus processos de preparação, e medicamentos | |
| BRPI0411122A (pt) | pirazol[3,4-b]piridin-6-onas como inibidores gsk-3 | |
| BRPI0508107A (pt) | derivados de indazol e composições farmacêuticas contendo os mesmos | |
| BRPI0409884A (pt) | compostos, composições farmacêuticas, método para o tratamento ou porfilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos | |
| BR0213037A (pt) | Derivados de pirimidina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2313 DE 05-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |