BRPI0411095B8 - derivados de imidazol, seus usos e seus processos de preparação, e medicamentos - Google Patents

derivados de imidazol, seus usos e seus processos de preparação, e medicamentos

Info

Publication number
BRPI0411095B8
BRPI0411095B8 BRPI0411095A BRPI0411095A BRPI0411095B8 BR PI0411095 B8 BRPI0411095 B8 BR PI0411095B8 BR PI0411095 A BRPI0411095 A BR PI0411095A BR PI0411095 A BRPI0411095 A BR PI0411095A BR PI0411095 B8 BRPI0411095 B8 BR PI0411095B8
Authority
BR
Brazil
Prior art keywords
imidazole derivatives
drugs
preparation processes
manufacture
mglur5 receptor
Prior art date
Application number
BRPI0411095A
Other languages
English (en)
Inventor
Buettelmann Bernd
Vieira Eric
Jaeschke Georg
Hugh Phillip Porter Richard
Kolczewski Sabine
Maria Ceccarelli Simona
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0411095A publication Critical patent/BRPI0411095A/pt
Publication of BRPI0411095B1 publication Critical patent/BRPI0411095B1/pt
Publication of BRPI0411095B8 publication Critical patent/BRPI0411095B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"derivados de imidazol". a presente invenção diz respeito aos derivados de imidazol que são antagonistas do receptor de mglur5 e que são representados pela fórmula geral (i): em que r^ 1^, r^ 2^, r^ 3^ e r^ 4^ são como definidos no relatório descritivo, a um processo para a sua fabricação, assim como aos seus sais farmaceuticamente aceitáveis para a fabricação de um medicamento para o tratamento ou prevenção dos distúrbios mediados pelo receptor de mglur5, tais como os distúrbios neurológicos agudos e/ou crônicos.
BRPI0411095A 2003-06-05 2004-06-01 derivados de imidazol, seus usos e seus processos de preparação, e medicamentos BRPI0411095B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03012200 2003-06-05
EP03012200.6 2003-06-05
PCT/EP2004/005881 WO2004108701A1 (en) 2003-06-05 2004-06-01 Imidazole derivatives as glutmate receptor antagonists

Publications (3)

Publication Number Publication Date
BRPI0411095A BRPI0411095A (pt) 2006-07-18
BRPI0411095B1 BRPI0411095B1 (pt) 2018-04-03
BRPI0411095B8 true BRPI0411095B8 (pt) 2021-05-25

Family

ID=33483899

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411095A BRPI0411095B8 (pt) 2003-06-05 2004-06-01 derivados de imidazol, seus usos e seus processos de preparação, e medicamentos

Country Status (38)

Country Link
US (3) US7332510B2 (pt)
EP (1) EP1636206B1 (pt)
JP (1) JP4401384B2 (pt)
KR (1) KR100778948B1 (pt)
CN (1) CN100408572C (pt)
AR (1) AR044478A1 (pt)
AT (1) ATE377008T1 (pt)
AU (1) AU2004245208B2 (pt)
BR (1) BRPI0411095B8 (pt)
CA (1) CA2527315C (pt)
CL (1) CL2004001347A1 (pt)
CR (1) CR8094A (pt)
CY (1) CY1107856T1 (pt)
DE (1) DE602004009796T2 (pt)
DK (1) DK1636206T3 (pt)
EA (1) EA010577B1 (pt)
EC (1) ECSP056202A (pt)
ES (1) ES2294504T3 (pt)
GT (1) GT200400117A (pt)
HN (1) HN2004000208A (pt)
HR (1) HRP20070529T3 (pt)
IL (1) IL171930A (pt)
MA (1) MA27881A1 (pt)
MX (1) MXPA05013149A (pt)
MY (2) MY137272A (pt)
NO (1) NO332143B1 (pt)
NZ (1) NZ543637A (pt)
PA (1) PA8604101A1 (pt)
PE (1) PE20050162A1 (pt)
PL (1) PL1636206T3 (pt)
PT (1) PT1636206E (pt)
RS (1) RS53183B (pt)
SI (1) SI1636206T1 (pt)
TN (2) TNSN05309A1 (pt)
TW (1) TWI338007B (pt)
UA (1) UA80888C2 (pt)
WO (1) WO2004108701A1 (pt)
ZA (2) ZA200509807B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7531529B2 (en) 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
US7452909B2 (en) 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
KR100907108B1 (ko) * 2004-06-01 2009-07-09 에프. 호프만-라 로슈 아게 Ｍｇｌｕ5 수용체 길항제로서 피리딘-4-일-에틴일-이미다졸및 피라졸
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
DE102006011574A1 (de) 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
ES2577391T3 (es) 2006-12-21 2016-07-14 F. Hoffmann-La Roche Ag Polimorfos de un antagonista del receptor mglur5
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US20120040008A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120039999A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
WO2012127393A1 (en) 2011-03-18 2012-09-27 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
MX2015002823A (es) * 2012-10-18 2015-05-15 Hoffmann La Roche Derivados de etilinilo como moduladores de la actividad del receptor de glutamato metabotropico 5 (mglur5).
ES2599553T3 (es) * 2012-10-18 2017-02-02 F. Hoffmann-La Roche Ag Derivados de etinilo como moduladores de la actividad del receptor mGluR5
CN108883104A (zh) * 2016-03-30 2018-11-23 森泰克希斯公司 用于在治疗成熟脑损伤中使用的mGluR5的负性变构调节剂
JP2023504177A (ja) * 2019-12-02 2023-02-01 エフ．ホフマン－ラ ロシュ アーゲー アルキニル－（ヘテロアリール）－カルボキサミドｈｃｎ１阻害剤
KR20250116184A (ko) 2020-06-05 2025-07-31 노에마 파르마 아게 결절성 경화증 복합증의 치료 방법
WO2022023519A1 (en) * 2020-07-30 2022-02-03 Noema Pharma Ag Methods of treatment of trigeminal neuralgia
KR20250140536A (ko) 2023-02-02 2025-09-25 노에마 파르마 아게 드라베 증후군의 치료 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508560A (en) 1981-11-11 1985-04-02 Ciba Geigy Corporation Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
EP1214303A1 (en) * 1999-08-31 2002-06-19 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof
DK1303495T3 (da) * 2000-07-24 2010-09-20 Krenitsky Pharmaceuticals Inc Substituerede 5-alkylnylpyrimidiner med neurotrofisk aktivitet
MXPA03004862A (es) * 2000-12-04 2005-02-14 Hoffmann La Roche Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato.
CA2470612A1 (en) * 2001-12-19 2003-07-03 Merck & Co., Inc. Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
WO2004038374A2 (en) * 2002-10-24 2004-05-06 Merck & Co., Inc. Alkyne derivatives as tracers for metabotropic glutamate receptor binding
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en) * 2003-07-03 2006-08-15 Hoffmann-La Roche Inc. Imidazole derivatives

Also Published As

Publication number Publication date
US20080119489A1 (en) 2008-05-22
CA2527315C (en) 2010-08-10
HK1093070A1 (zh) 2007-02-23
CN100408572C (zh) 2008-08-06
CR8094A (es) 2006-05-30
AU2004245208A1 (en) 2004-12-16
CY1107856T1 (el) 2013-06-19
MY143353A (en) 2011-04-29
TNSN06391A1 (fr) 2008-02-22
DE602004009796T2 (de) 2008-08-28
KR20060057537A (ko) 2006-05-26
US20080103306A1 (en) 2008-05-01
US20040248888A1 (en) 2004-12-09
CL2004001347A1 (es) 2005-05-06
US7973165B2 (en) 2011-07-05
BRPI0411095A (pt) 2006-07-18
RS53183B (sr) 2014-06-30
PT1636206E (pt) 2008-01-28
MXPA05013149A (es) 2006-03-17
KR100778948B1 (ko) 2007-11-28
NO20055465L (no) 2005-11-18
SI1636206T1 (sl) 2008-02-29
PL1636206T3 (pl) 2008-04-30
DK1636206T3 (da) 2008-02-11
US7332510B2 (en) 2008-02-19
ZA200609681B (en) 2008-06-25
PE20050162A1 (es) 2005-03-22
IL171930A (en) 2010-12-30
MA27881A1 (fr) 2006-05-02
WO2004108701A1 (en) 2004-12-16
ES2294504T3 (es) 2008-04-01
ECSP056202A (es) 2006-04-19
EP1636206A1 (en) 2006-03-22
MY137272A (en) 2009-01-30
EP1636206B1 (en) 2007-10-31
UA80888C2 (en) 2007-11-12
RS20050892A (sr) 2007-12-31
JP2006526588A (ja) 2006-11-24
EA010577B1 (ru) 2008-10-30
IL171930A0 (en) 2006-04-10
TNSN05309A1 (fr) 2007-07-10
NO332143B1 (no) 2012-07-02
EA200501887A1 (ru) 2006-10-27
TW200509920A (en) 2005-03-16
NZ543637A (en) 2008-04-30
JP4401384B2 (ja) 2010-01-20
HN2004000208A (es) 2009-02-03
GT200400117A (es) 2005-02-07
ZA200509807B (en) 2006-12-27
ATE377008T1 (de) 2007-11-15
AU2004245208B2 (en) 2007-04-26
BRPI0411095B1 (pt) 2018-04-03
CN1802367A (zh) 2006-07-12
DE602004009796D1 (de) 2007-12-13
AR044478A1 (es) 2005-09-14
HRP20070529T3 (hr) 2008-05-31
CA2527315A1 (en) 2004-12-16
PA8604101A1 (es) 2004-12-16
TWI338007B (en) 2011-03-01
US8481548B2 (en) 2013-07-09

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/06/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

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