BRPI0411095B8 - derivados de imidazol, seus usos e seus processos de preparação, e medicamentos - Google Patents

derivados de imidazol, seus usos e seus processos de preparação, e medicamentos

Info

Publication number
BRPI0411095B8
BRPI0411095B8 BRPI0411095A BRPI0411095A BRPI0411095B8 BR PI0411095 B8 BRPI0411095 B8 BR PI0411095B8 BR PI0411095 A BRPI0411095 A BR PI0411095A BR PI0411095 A BRPI0411095 A BR PI0411095A BR PI0411095 B8 BRPI0411095 B8 BR PI0411095B8
Authority
BR
Brazil
Prior art keywords
imidazole derivatives
drugs
preparation processes
manufacture
mglur5 receptor
Prior art date
Application number
BRPI0411095A
Other languages
English (en)
Inventor
Buettelmann Bernd
Vieira Eric
Jaeschke Georg
Hugh Phillip Porter Richard
Kolczewski Sabine
Maria Ceccarelli Simona
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0411095A publication Critical patent/BRPI0411095A/pt
Publication of BRPI0411095B1 publication Critical patent/BRPI0411095B1/pt
Publication of BRPI0411095B8 publication Critical patent/BRPI0411095B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"derivados de imidazol". a presente invenção diz respeito aos derivados de imidazol que são antagonistas do receptor de mglur5 e que são representados pela fórmula geral (i): em que r^ 1^, r^ 2^, r^ 3^ e r^ 4^ são como definidos no relatório descritivo, a um processo para a sua fabricação, assim como aos seus sais farmaceuticamente aceitáveis para a fabricação de um medicamento para o tratamento ou prevenção dos distúrbios mediados pelo receptor de mglur5, tais como os distúrbios neurológicos agudos e/ou crônicos.
BRPI0411095A 2003-06-05 2004-06-01 derivados de imidazol, seus usos e seus processos de preparação, e medicamentos BRPI0411095B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03012200.6 2003-06-05
EP03012200 2003-06-05
PCT/EP2004/005881 WO2004108701A1 (en) 2003-06-05 2004-06-01 Imidazole derivatives as glutmate receptor antagonists

Publications (3)

Publication Number Publication Date
BRPI0411095A BRPI0411095A (pt) 2006-07-18
BRPI0411095B1 BRPI0411095B1 (pt) 2018-04-03
BRPI0411095B8 true BRPI0411095B8 (pt) 2021-05-25

Family

ID=33483899

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411095A BRPI0411095B8 (pt) 2003-06-05 2004-06-01 derivados de imidazol, seus usos e seus processos de preparação, e medicamentos

Country Status (38)

Country Link
US (3) US7332510B2 (pt)
EP (1) EP1636206B1 (pt)
JP (1) JP4401384B2 (pt)
KR (1) KR100778948B1 (pt)
CN (1) CN100408572C (pt)
AR (1) AR044478A1 (pt)
AT (1) ATE377008T1 (pt)
AU (1) AU2004245208B2 (pt)
BR (1) BRPI0411095B8 (pt)
CA (1) CA2527315C (pt)
CL (1) CL2004001347A1 (pt)
CR (1) CR8094A (pt)
CY (1) CY1107856T1 (pt)
DE (1) DE602004009796T2 (pt)
DK (1) DK1636206T3 (pt)
EA (1) EA010577B1 (pt)
EC (1) ECSP056202A (pt)
ES (1) ES2294504T3 (pt)
GT (1) GT200400117A (pt)
HN (1) HN2004000208A (pt)
HR (1) HRP20070529T3 (pt)
IL (1) IL171930A (pt)
MA (1) MA27881A1 (pt)
MX (1) MXPA05013149A (pt)
MY (2) MY137272A (pt)
NO (1) NO332143B1 (pt)
NZ (1) NZ543637A (pt)
PA (1) PA8604101A1 (pt)
PE (1) PE20050162A1 (pt)
PL (1) PL1636206T3 (pt)
PT (1) PT1636206E (pt)
RS (1) RS53183B (pt)
SI (1) SI1636206T1 (pt)
TN (2) TNSN05309A1 (pt)
TW (1) TWI338007B (pt)
UA (1) UA80888C2 (pt)
WO (1) WO2004108701A1 (pt)
ZA (2) ZA200509807B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7531529B2 (en) 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
US7452909B2 (en) 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
HRP20080363T3 (hr) 2004-06-01 2008-09-30 F. Hoffmann - La Roche Ag Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
DE102006011574A1 (de) 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
MY148217A (en) * 2006-12-21 2013-03-29 Hoffmann La Roche Polymorphs of a mglur5 receptor antagonist
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US20120040008A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120039999A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20140228398A1 (en) 2011-03-18 2014-08-14 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
EP2909180B1 (en) * 2012-10-18 2016-10-05 F. Hoffmann-La Roche AG Ethynyl derivatives as modulators of mglur5 receptor activity
EA026941B1 (ru) * 2012-10-18 2017-06-30 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ ЭТИНИЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ АКТИВНОСТИ РЕЦЕПТОРА mGluR5
MX2018011765A (es) * 2016-03-30 2019-05-20 Sinntaxis AB Moduladores alostéricos negativos del receptor 5 metabotrópico de glutamato (mglur5) para su uso en el tratamiento de daños cerebrales maduros.
IL298709A (en) * 2020-06-05 2023-02-01 Noema Pharma Ag Methods for treating multiple sclerosis complex
CN115989024A (zh) 2020-07-30 2023-04-18 诺埃玛制药公司 治疗三叉神经痛的方法
CN120641098A (zh) 2023-02-02 2025-09-12 诺埃玛制药公司 Dravet综合征的治疗方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079312A3 (de) * 1981-11-11 1984-04-25 Ciba-Geigy Ag Heterocyclische Acetylenverbindungen
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
WO2001016121A1 (en) * 1999-08-31 2001-03-08 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof
JP5154728B2 (ja) * 2000-07-24 2013-02-27 クレニツキー・ファーマシューティカルズ，インコーポレイテッド 神経栄養活性を有する置換５−アルキニルピリミジン
ATE288898T1 (de) * 2000-12-04 2005-02-15 Hoffmann La Roche Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
EP1458385A4 (en) * 2001-12-19 2005-12-21 Merck & Co Inc METABOTROPIC GLUTAMATE RECEPTOR 5-HETEROARYL-SUBSTITUTED IMIDAZOLE MODULATORS
EP1556142A4 (en) * 2002-10-24 2006-11-08 Merck & Co Inc ALKYN DERIVATIVES AS TRACERS FOR THE METABOTROPE GLUTAMATE RECEPTOR BINDING
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en) * 2003-07-03 2006-08-15 Hoffmann-La Roche Inc. Imidazole derivatives

Also Published As

Publication number Publication date
US20040248888A1 (en) 2004-12-09
CA2527315C (en) 2010-08-10
CL2004001347A1 (es) 2005-05-06
US7332510B2 (en) 2008-02-19
PT1636206E (pt) 2008-01-28
IL171930A0 (en) 2006-04-10
ZA200509807B (en) 2006-12-27
TW200509920A (en) 2005-03-16
EA010577B1 (ru) 2008-10-30
KR100778948B1 (ko) 2007-11-28
MXPA05013149A (es) 2006-03-17
MY143353A (en) 2011-04-29
CN100408572C (zh) 2008-08-06
MA27881A1 (fr) 2006-05-02
ECSP056202A (es) 2006-04-19
EP1636206B1 (en) 2007-10-31
SI1636206T1 (sl) 2008-02-29
HRP20070529T3 (hr) 2008-05-31
HN2004000208A (es) 2009-02-03
ES2294504T3 (es) 2008-04-01
UA80888C2 (en) 2007-11-12
WO2004108701A1 (en) 2004-12-16
DE602004009796D1 (de) 2007-12-13
TNSN05309A1 (fr) 2007-07-10
HK1093070A1 (zh) 2007-02-23
US20080119489A1 (en) 2008-05-22
RS20050892A (sr) 2007-12-31
CR8094A (es) 2006-05-30
NO20055465L (no) 2005-11-18
CA2527315A1 (en) 2004-12-16
US7973165B2 (en) 2011-07-05
JP2006526588A (ja) 2006-11-24
IL171930A (en) 2010-12-30
ATE377008T1 (de) 2007-11-15
AU2004245208B2 (en) 2007-04-26
KR20060057537A (ko) 2006-05-26
US20080103306A1 (en) 2008-05-01
PE20050162A1 (es) 2005-03-22
TNSN06391A1 (fr) 2008-02-22
PL1636206T3 (pl) 2008-04-30
EA200501887A1 (ru) 2006-10-27
DK1636206T3 (da) 2008-02-11
JP4401384B2 (ja) 2010-01-20
EP1636206A1 (en) 2006-03-22
MY137272A (en) 2009-01-30
RS53183B (sr) 2014-06-30
BRPI0411095B1 (pt) 2018-04-03
DE602004009796T2 (de) 2008-08-28
GT200400117A (es) 2005-02-07
TWI338007B (en) 2011-03-01
US8481548B2 (en) 2013-07-09
AU2004245208A1 (en) 2004-12-16
CN1802367A (zh) 2006-07-12
NZ543637A (en) 2008-04-30
ZA200609681B (en) 2008-06-25
CY1107856T1 (el) 2013-06-19
AR044478A1 (es) 2005-09-14
PA8604101A1 (es) 2004-12-16
NO332143B1 (no) 2012-07-02
BRPI0411095A (pt) 2006-07-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/06/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2830 DE 01-04-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.