BRPI0412445A - processo para preparação de partìculas cristalinas de tamanho mìcron, usando um solvente, um não-solvente e energia ultra-sÈnica - Google Patents

processo para preparação de partìculas cristalinas de tamanho mìcron, usando um solvente, um não-solvente e energia ultra-sÈnica

Info

Publication number
BRPI0412445A
BRPI0412445A BRPI0412445-6A BRPI0412445A BRPI0412445A BR PI0412445 A BRPI0412445 A BR PI0412445A BR PI0412445 A BRPI0412445 A BR PI0412445A BR PI0412445 A BRPI0412445 A BR PI0412445A
Authority
BR
Brazil
Prior art keywords
solvent
crystalline particles
ultrasonic energy
micron sized
sized crystalline
Prior art date
Application number
BRPI0412445-6A
Other languages
English (en)
Inventor
Philippe Rogueda
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0412445A publication Critical patent/BRPI0412445A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0063—Control or regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Silicon Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE PARTìCULAS CRISTALINAS DE TAMANHO MìCRON, USANDO UM SOLVENTE, UM NãO-SOLVENTE E ENERGIA ULTRA-SÈNICA". A presente invenção refere-se a um novo procedimento, para produção com alto rendimento de pequenas partículas cristalinas, com uma estreita distribuição de tamanho.
BRPI0412445-6A 2003-07-07 2004-07-05 processo para preparação de partìculas cristalinas de tamanho mìcron, usando um solvente, um não-solvente e energia ultra-sÈnica BRPI0412445A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0302029A SE0302029D0 (sv) 2003-07-07 2003-07-07 Novel process
PCT/GB2004/002882 WO2005004847A1 (en) 2003-07-07 2004-07-05 Novel process

Publications (1)

Publication Number Publication Date
BRPI0412445A true BRPI0412445A (pt) 2006-09-19

Family

ID=27764955

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412445-6A BRPI0412445A (pt) 2003-07-07 2004-07-05 processo para preparação de partìculas cristalinas de tamanho mìcron, usando um solvente, um não-solvente e energia ultra-sÈnica

Country Status (14)

Country Link
US (1) US20060188579A1 (pt)
EP (1) EP1648414A1 (pt)
JP (1) JP2007527381A (pt)
KR (1) KR20060052779A (pt)
CN (1) CN1819818A (pt)
AU (1) AU2004255517A1 (pt)
BR (1) BRPI0412445A (pt)
CA (1) CA2531025A1 (pt)
IL (1) IL172771A0 (pt)
MX (1) MXPA05014075A (pt)
NO (1) NO20060607L (pt)
SE (1) SE0302029D0 (pt)
WO (1) WO2005004847A1 (pt)
ZA (1) ZA200600110B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032054A1 (it) 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
ATE552032T1 (de) 2005-07-14 2012-04-15 Lithera Inc Verbesserte lipolytikum-formulierung mit hinhaltender wirkstofffreigabe für die arealbehandlung von fettgewebe
ES2398480T3 (es) * 2006-10-17 2013-03-19 Lithera, Inc. Procedimientos, composiciones, y formulaciones para el tratamiento de la enfermedad ocular tiroidea
GB0806873D0 (en) * 2008-04-16 2008-05-21 Breath Ltd Steroid nebuliser formulation
EP2321022B1 (en) * 2008-07-18 2016-11-02 Prosonix Limited Process for improving crystallinity
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
KR20120113267A (ko) * 2010-01-15 2012-10-12 리쎄라 인코오포레이티드 동결건조 케이크 제제
AU2011305567A1 (en) 2010-09-22 2013-05-02 Map Pharmaceuticals, Inc. Corticosteroid particles and method of production
CN103269693A (zh) 2010-11-24 2013-08-28 利赛拉公司 选择性、亲脂性及长效型β激动剂单一治疗调配物和用于肥胖及外形凸起的美容治疗的方法
CN103429267B (zh) * 2011-01-09 2016-05-04 Anp科技公司 疏水分子诱导的支化聚合物集合体及其用途
CN102807585B (zh) * 2012-08-06 2015-08-12 广西田园生化股份有限公司 一种采用超声波辅助技术结晶毒氟磷的方法
CN103588846B (zh) * 2012-08-15 2016-08-03 重庆华邦制药有限公司 一种丙酸氟替卡松微粒的制备方法及其用途
US9855538B2 (en) 2013-03-08 2018-01-02 The Board Of Trustees Of The University Of Illinois Ultrasonic method and apparatus for producing particles having a controlled size distribution
CN109988074A (zh) * 2018-06-01 2019-07-09 药璞(上海)医药科技有限公司 一种适合药用的硫酸特布他林晶型b的制备方法
WO2022134000A1 (zh) * 2020-12-25 2022-06-30 深圳晶泰科技有限公司 连续激发结晶的方法及系统

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
EP1409101B1 (en) * 2001-05-05 2006-04-12 Accentus plc Formation of small crystals
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
ATE551993T1 (de) * 2002-10-17 2012-04-15 Boehringer Ingelheim Pharma Verfahren und reaktor zur herstellung von pulvern für inhalative medikamente

Also Published As

Publication number Publication date
SE0302029D0 (sv) 2003-07-07
IL172771A0 (en) 2006-04-10
CN1819818A (zh) 2006-08-16
EP1648414A1 (en) 2006-04-26
ZA200600110B (en) 2007-01-31
CA2531025A1 (en) 2005-01-20
US20060188579A1 (en) 2006-08-24
WO2005004847A1 (en) 2005-01-20
KR20060052779A (ko) 2006-05-19
AU2004255517A1 (en) 2005-01-20
NO20060607L (no) 2006-04-07
JP2007527381A (ja) 2007-09-27
MXPA05014075A (es) 2006-03-02

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]