BRPI0412913A - meio para tratamento de infecções por leishmaniose - Google Patents

meio para tratamento de infecções por leishmaniose

Info

Publication number
BRPI0412913A
BRPI0412913A BRPI0412913-0A BRPI0412913A BRPI0412913A BR PI0412913 A BRPI0412913 A BR PI0412913A BR PI0412913 A BRPI0412913 A BR PI0412913A BR PI0412913 A BRPI0412913 A BR PI0412913A
Authority
BR
Brazil
Prior art keywords
dna
leishmania
vaccine
expression construct
producing
Prior art date
Application number
BRPI0412913-0A
Other languages
English (en)
Inventor
Burghardt Wittig
Laura Fuertes-Lopez
Marcos Timon-Jimenez
Original Assignee
Mologen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mologen Ag filed Critical Mologen Ag
Publication of BRPI0412913A publication Critical patent/BRPI0412913A/pt
Publication of BRPI0412913B1 publication Critical patent/BRPI0412913B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/008—Leishmania antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"MEIO PARA TRATAMENTO DE INFECçõES POR LEISHMANIOSE". A invenção refere-se ao uso de uma combinação de construções da expressão de DNA para a produção de um medicamento para imunização contra infecções com leishmaniose, bem como uma vacina correspondente. As construções da expressão de DNA em si são também um objeto da invenção. De acordo com a invenção, pretende-se de preferência que o antígeno imunogênico p36 LACK seja utilizado em combinação com o antígeno da proteína antioxidante específica de tiol de Leishmania infantum (TSA), o antígeno da proteína 11 de membrana do cinetoplasto de Leishmania infantum (Kmp-11) e o antígeno de glicoproteína 63 de Leishmania infantum (gp63), para a geração de uma resposta imune. Na qualidade de plasmídeos das construções da expressão de DNA, podem ser utilizados plasmídeos de construções de expressão, e de preferência são utilizadas as construções da expressão gênica minimalística, imunologicamente definida (MIDGE), de acordo com invenção. Outras construções da expressão de DNA de acordo com invenção são utilizadas para a produção de uma vacina de doenças por infecção com leishmaniose e fazem parte de uma vacina correspondente.
BRPI0412913-0A 2003-10-24 2004-10-22 Métodos para usar uma construção da expressão de dna; usar duas ou três construções da expressão de dna; usar as construções da expressão de dna para a produção de uma vacina para o tratamento de doenças de infecções por leishmaniose; usar duas ou três construções da expressão de dna para a produção de uma vacina para o tratamento de doenças de infecções por leishmaniose; construções da expressão de dna; e vacina para o tratamento de doenças de infecções por leishmaniose BRPI0412913B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03090368.6 2003-10-24
EP03090368 2003-10-24
PCT/DE2004/002383 WO2005039633A1 (de) 2003-10-24 2004-10-22 Mittel zur behandlung von infektionen mit leishmanien

Publications (2)

Publication Number Publication Date
BRPI0412913A true BRPI0412913A (pt) 2006-12-26
BRPI0412913B1 BRPI0412913B1 (pt) 2018-04-03

Family

ID=34486323

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412913-0A BRPI0412913B1 (pt) 2003-10-24 2004-10-22 Métodos para usar uma construção da expressão de dna; usar duas ou três construções da expressão de dna; usar as construções da expressão de dna para a produção de uma vacina para o tratamento de doenças de infecções por leishmaniose; usar duas ou três construções da expressão de dna para a produção de uma vacina para o tratamento de doenças de infecções por leishmaniose; construções da expressão de dna; e vacina para o tratamento de doenças de infecções por leishmaniose

Country Status (11)

Country Link
US (2) US7795406B2 (pt)
EP (1) EP1615663B1 (pt)
AT (1) ATE381942T1 (pt)
BR (1) BRPI0412913B1 (pt)
CY (1) CY1107286T1 (pt)
DE (1) DE502004005784D1 (pt)
DK (1) DK1615663T3 (pt)
ES (1) ES2298829T3 (pt)
MX (1) MXPA06004025A (pt)
PT (1) PT1615663E (pt)
WO (1) WO2005039633A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2711670B1 (fr) 1993-10-22 1996-01-12 Pasteur Institut Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite.
WO2006058243A2 (en) * 2004-11-24 2006-06-01 Yale University Leishmania antigens and related compositions and uses
US7794736B2 (en) 2006-11-21 2010-09-14 Merial Limited Canine Leishmania vaccine
IN2008DE00516A (pt) * 2008-03-05 2009-09-18
MX2010012069A (es) * 2008-05-08 2010-12-14 Merial Ltd Vacuna de la leishmaniasis con el uso del inmunogeno salival de la mosca de la arena.
US8410258B2 (en) 2008-05-21 2013-04-02 Infections Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
BRPI0912768A2 (pt) 2008-05-21 2016-05-17 Infectious Disease Res Inst vacinas de poliproteínas recombinante para o tratamento e diagnóstico de leishmaniose
EP3323424A1 (en) * 2016-11-17 2018-05-23 Cyanimal IP Cyaa polypeptides as immune enhancer
CN118414162A (zh) * 2021-12-23 2024-07-30 英特维特国际股份有限公司 抗利什曼病的dna疫苗
CN116903753B (zh) * 2023-06-20 2024-02-20 安徽中起生物科技有限公司 一种广谱抗原虫多肽及其制备与应用
WO2025006573A2 (en) * 2023-06-27 2025-01-02 Elanco Us Inc. Codon optimized pmcv sequences

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638517B2 (en) * 1995-09-22 2003-10-28 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
US20020169285A1 (en) * 1995-09-22 2002-11-14 Reed Steven G. Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
DE19648625A1 (de) 1996-11-13 1998-05-14 Soft Gene Gmbh Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer
DE19826758C1 (de) * 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
US6458359B1 (en) * 1998-12-23 2002-10-01 C.B.F. Leti S.A. Chimeric gene formed by the dna sequences that encode the antigenic determinants of four proteins of l. infantum and protein encoded by said gene, and pharmacuetical composition useful for preventing and/or treating leishmaniosis in animals or humans
DE19935756A1 (de) 1999-07-27 2001-02-08 Mologen Forschungs Entwicklung Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
EP1432439B1 (de) * 2001-10-02 2005-12-07 Mologen AG Mittel zur verbesserung der immunantwort

Also Published As

Publication number Publication date
MXPA06004025A (es) 2006-06-28
US8669100B2 (en) 2014-03-11
DK1615663T3 (da) 2008-03-31
US20060194753A1 (en) 2006-08-31
BRPI0412913B1 (pt) 2018-04-03
US20110223189A1 (en) 2011-09-15
WO2005039633A1 (de) 2005-05-06
DE502004005784D1 (de) 2008-02-07
CY1107286T1 (el) 2012-11-21
EP1615663B1 (de) 2007-12-26
ES2298829T3 (es) 2008-05-16
ATE381942T1 (de) 2008-01-15
EP1615663A1 (de) 2006-01-18
PT1615663E (pt) 2008-03-28
US7795406B2 (en) 2010-09-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07C Technical examination (opinion): republication [chapter 7.3 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2600 DE 03-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.