BRPI0412933A - derivados de nicotinamida úteis como inibidores de pde4 - Google Patents

derivados de nicotinamida úteis como inibidores de pde4

Info

Publication number
BRPI0412933A
BRPI0412933A BRPI0412933-4A BRPI0412933A BRPI0412933A BR PI0412933 A BRPI0412933 A BR PI0412933A BR PI0412933 A BRPI0412933 A BR PI0412933A BR PI0412933 A BRPI0412933 A BR PI0412933A
Authority
BR
Brazil
Prior art keywords
derivatives
pde4 inhibitors
derivatives useful
nicotinamide derivatives
nicotinamide
Prior art date
Application number
BRPI0412933-4A
Other languages
English (en)
Inventor
John Paul Mathias
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0412933A publication Critical patent/BRPI0412933A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE NICOTINAMIDA úTEIS COMO INIBIDORES DE PDE4". Esta invenção relaciona-se com derivados de nicotinamida de fórmula geral (I): em que R¬ 1¬, R¬ 2¬ e R¬ 3¬ têm os significados aqui definidos, e com processos para a preparação de tais derivados, intermediários usados na preparação de tais derivados, composições contendo tais derivados e os usos de tais derivados.
BRPI0412933-4A 2003-07-25 2004-07-13 derivados de nicotinamida úteis como inibidores de pde4 BRPI0412933A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317509.8A GB0317509D0 (en) 2003-07-25 2003-07-25 Nicotinamide derivatives useful as PDE4 inhibitors
PCT/IB2004/002365 WO2005010001A1 (en) 2003-07-25 2004-07-13 Nicotinamide derivatives useful as pdea4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0412933A true BRPI0412933A (pt) 2006-09-26

Family

ID=27772736

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412933-4A BRPI0412933A (pt) 2003-07-25 2004-07-13 derivados de nicotinamida úteis como inibidores de pde4

Country Status (7)

Country Link
EP (1) EP1651647A1 (pt)
JP (1) JP2006528623A (pt)
BR (1) BRPI0412933A (pt)
CA (1) CA2533681A1 (pt)
GB (1) GB0317509D0 (pt)
MX (1) MXPA06000988A (pt)
WO (1) WO2005010001A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
EP1888033B1 (en) * 2005-06-09 2014-02-19 Meda AB Method and composition for treating inflammatory disorders
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
WO2007019232A2 (en) * 2005-08-03 2007-02-15 Immunogen, Inc. Immunoconjugate formulations
PT2297106E (pt) * 2008-05-27 2014-09-29 Astrazeneca Ab Derivados de fenoxipiridinilamida e seu uso no tratamento de estados de doença mediados por pde4
CN116490088B (zh) * 2020-12-18 2026-08-11 菲利普莫里斯生产公司 吸入器制品和用于与其一起使用的囊

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2285548C (en) * 1997-04-04 2006-07-11 Pfizer Products Inc. Nicotinamide derivatives
MXPA04007737A (es) * 2002-02-11 2004-10-15 Pfizer Derivados de nicotinamida utiles como inhibidores de fosfodesterasas 4.
GB0203193D0 (en) * 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors

Also Published As

Publication number Publication date
WO2005010001A1 (en) 2005-02-03
JP2006528623A (ja) 2006-12-21
MXPA06000988A (es) 2006-04-11
GB0317509D0 (en) 2003-08-27
CA2533681A1 (en) 2005-02-03
EP1651647A1 (en) 2006-05-03

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]