BRPI0207172B8 - pirido-pirimidinas 6-substituída, sua composição e seu uso, bem como seu intermediário - Google Patents

pirido-pirimidinas 6-substituída, sua composição e seu uso, bem como seu intermediário

Info

Publication number
BRPI0207172B8
BRPI0207172B8 BRPI0207172A BRPI0207172B8 BR PI0207172 B8 BRPI0207172 B8 BR PI0207172B8 BR PI0207172 A BRPI0207172 A BR PI0207172A BR PI0207172 B8 BRPI0207172 B8 BR PI0207172B8
Authority
BR
Brazil
Prior art keywords
pyrimidines
composition
well
substituted pyrido
substituted
Prior art date
Application number
Other languages
English (en)
Inventor
Martin Stahl Christoph
Michael Goldstein David
Patrick Dunn James
Jeffrey Chen Jian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0207172A publication Critical patent/BR0207172A/pt
Publication of BRPI0207172B1 publication Critical patent/BRPI0207172B1/pt
Publication of BRPI0207172B8 publication Critical patent/BRPI0207172B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"pirido-pirimidinas 6-substituídas". a presente invenção refere-se a compostos da fórmula i e ii: fórmula ii em que r^ 1^, r^ 3^, w, z, x^ 1^, ?, ~ x~2, ~ ar~1<sym>, r^ 8^ e r^ 9^ são como definidos aqui, processos e intermediários para sua preparação e seu uso para o tratamento de distúrbios mediados por p38.
BR0207172-0 2001-02-12 2002-02-04 pirido-pirimidinas 6-substituída, sua composição e seu uso, bem como seu intermediário BRPI0207172B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US60/268,375 2001-02-12
US33465401P 2001-11-30 2001-11-30
US60/334,654 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines

Publications (3)

Publication Number Publication Date
BR0207172A BR0207172A (pt) 2004-03-30
BRPI0207172B1 BRPI0207172B1 (pt) 2019-04-09
BRPI0207172B8 true BRPI0207172B8 (pt) 2021-05-25

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207172-0 BRPI0207172B8 (pt) 2001-02-12 2002-02-04 pirido-pirimidinas 6-substituída, sua composição e seu uso, bem como seu intermediário

Country Status (31)

Country Link
US (3) US6696566B2 (pt)
EP (1) EP1361880B1 (pt)
JP (1) JP4064818B2 (pt)
KR (1) KR100639772B1 (pt)
CN (1) CN100376571C (pt)
AR (1) AR035854A1 (pt)
AT (1) ATE305303T1 (pt)
AU (1) AU2002256615B2 (pt)
BR (1) BRPI0207172B8 (pt)
CA (1) CA2434834C (pt)
CZ (1) CZ20032416A3 (pt)
DE (1) DE60206363T2 (pt)
DK (1) DK1361880T3 (pt)
ES (1) ES2249574T3 (pt)
HR (1) HRP20030624B1 (pt)
HU (1) HU229604B1 (pt)
IL (2) IL156872A0 (pt)
JO (1) JO2410B1 (pt)
MA (1) MA26993A1 (pt)
MX (1) MXPA03007166A (pt)
MY (1) MY131518A (pt)
NO (1) NO326133B1 (pt)
NZ (1) NZ526961A (pt)
PA (1) PA8539201A1 (pt)
PE (1) PE20020976A1 (pt)
PL (1) PL366918A1 (pt)
RU (1) RU2269527C2 (pt)
SK (1) SK11322003A3 (pt)
WO (1) WO2002064594A2 (pt)
YU (1) YU63703A (pt)
ZA (1) ZA200305938B (pt)

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RU2324695C2 (ru) 2002-08-06 2008-05-20 Ф.Хоффманн-Ля Рош Аг 6-АЛКОКСИПИРИДОПИРИМИДИНЫ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АКТИВНОСТЬЮ ИНГИБИТОРОВ КИНАЗЫ МАР р38
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US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
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Also Published As

Publication number Publication date
US7169794B2 (en) 2007-01-30
HRP20030624B1 (en) 2007-03-31
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
HRP20030624A2 (en) 2005-06-30
CN1503672A (zh) 2004-06-09
HUP0303458A3 (en) 2012-12-28
DE60206363T2 (de) 2006-07-06
SK11322003A3 (en) 2004-10-05
ATE305303T1 (de) 2005-10-15
JO2410B1 (en) 2007-06-17
IL156872A0 (en) 2004-02-08
PL366918A1 (en) 2005-02-07
US20070135458A1 (en) 2007-06-14
US6696566B2 (en) 2004-02-24
ES2249574T3 (es) 2006-04-01
EP1361880B1 (en) 2005-09-28
DK1361880T3 (da) 2006-01-23
HUP0303458A2 (hu) 2004-01-28
RU2269527C2 (ru) 2006-02-10
CZ20032416A3 (cs) 2004-07-14
JP4064818B2 (ja) 2008-03-19
MY131518A (en) 2007-08-30
KR20040018254A (ko) 2004-03-02
BRPI0207172B1 (pt) 2019-04-09
HU229604B1 (en) 2014-02-28
YU63703A (sh) 2006-05-25
NO326133B1 (no) 2008-10-06
CA2434834C (en) 2010-09-14
US20040116698A1 (en) 2004-06-17
BR0207172A (pt) 2004-03-30
CA2434834A1 (en) 2002-08-22
IL156872A (en) 2009-07-20
NO20033540D0 (no) 2003-08-11
RU2003125887A (ru) 2005-03-20
US20030171584A1 (en) 2003-09-11
AU2002256615B2 (en) 2007-09-13
MXPA03007166A (es) 2003-11-18
PA8539201A1 (es) 2004-08-31
HK1066170A1 (en) 2005-03-18
KR100639772B1 (ko) 2006-10-30
CN100376571C (zh) 2008-03-26
ZA200305938B (en) 2005-01-26
US7449581B2 (en) 2008-11-11
EP1361880A2 (en) 2003-11-19
WO2002064594A3 (en) 2003-01-09
WO2002064594A2 (en) 2002-08-22
NZ526961A (en) 2005-03-24
JP2004525896A (ja) 2004-08-26
AR035854A1 (es) 2004-07-21
DE60206363D1 (de) 2006-02-09
NO20033540L (no) 2003-08-11

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