BRPI0413158A - compostos de n-sulfonil-heterociclo-pirrolil-alquil-aminas como ligantes de 5-hidróxi-triptamina-6 - Google Patents

compostos de n-sulfonil-heterociclo-pirrolil-alquil-aminas como ligantes de 5-hidróxi-triptamina-6

Info

Publication number
BRPI0413158A
BRPI0413158A BRPI0413158-4A BRPI0413158A BRPI0413158A BR PI0413158 A BRPI0413158 A BR PI0413158A BR PI0413158 A BRPI0413158 A BR PI0413158A BR PI0413158 A BRPI0413158 A BR PI0413158A
Authority
BR
Brazil
Prior art keywords
sulfonylheterocyclopyrrolylalkylamine
binders
compounds
hydroxy tryptamine
tryptamine
Prior art date
Application number
BRPI0413158-4A
Other languages
English (en)
Inventor
Derek Cecil Cole
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0413158A publication Critical patent/BRPI0413158A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTOS DE N-SULFONIL-HETEROCICLO-PIRROLIL-ALQUIL-AMINAS COMO LIGANTES DE 5-HIDRóXI-TRIPTAMINA-6". A presente invenção fornece um composto da fórmula I e seu uso para o tratamento terapêutico de um distúrbio do sistema nervoso central relacionado ou afetado pelo receptor 5-HT6.
BRPI0413158-4A 2003-07-31 2004-07-23 compostos de n-sulfonil-heterociclo-pirrolil-alquil-aminas como ligantes de 5-hidróxi-triptamina-6 BRPI0413158A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49162203P 2003-07-31 2003-07-31
PCT/US2004/023993 WO2005012311A1 (en) 2003-07-31 2004-07-23 N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands

Publications (1)

Publication Number Publication Date
BRPI0413158A true BRPI0413158A (pt) 2006-10-03

Family

ID=34115532

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413158-4A BRPI0413158A (pt) 2003-07-31 2004-07-23 compostos de n-sulfonil-heterociclo-pirrolil-alquil-aminas como ligantes de 5-hidróxi-triptamina-6

Country Status (14)

Country Link
US (2) US7041695B2 (pt)
EP (1) EP1648904B1 (pt)
JP (1) JP2007500701A (pt)
CN (1) CN100443487C (pt)
AT (1) ATE370955T1 (pt)
AU (1) AU2004261606A1 (pt)
BR (1) BRPI0413158A (pt)
CA (1) CA2532382A1 (pt)
DE (1) DE602004008474T2 (pt)
DK (1) DK1648904T3 (pt)
ES (1) ES2290740T3 (pt)
MX (1) MXPA06000957A (pt)
PL (1) PL1648904T3 (pt)
WO (1) WO2005012311A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012311A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
GB0403781D0 (en) * 2004-02-20 2004-03-24 Astrazeneca Ab Chemical compounds
US7314875B2 (en) * 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
TW200800959A (en) * 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
MX2007015772A (es) * 2005-06-17 2008-02-22 Wyeth Corp Compuestos utiles como inhibidores de serotonina y agonistas y antagonistas de 5-ht-1a.
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200811144A (en) * 2006-06-09 2008-03-01 Wyeth Corp Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline
TW200808740A (en) * 2006-06-09 2008-02-16 Wyeth Corp Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof
AR063984A1 (es) * 2006-11-28 2009-03-04 Wyeth Corp Metabolitos de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina, metodos de preparacion, su uso en la fabricacion de medicamentos para el tratamiento de trastornos relacionados con 5-ht1a, composicion farmaceutica que los comprende, compuestos radioetiquetados derivado
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
EP2053052A1 (en) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
US20200128830A1 (en) 2017-04-24 2020-04-30 Bayer Aktiengesellschaft Fused bicyclic heterocycle derivatives as pesticides
CN120289484B (zh) * 2025-04-16 2026-04-10 聊城大学 一种吡咯烷酮并二氢异噁唑类化合物及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2537974A1 (fr) * 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
PT1149078E (pt) * 1998-12-11 2006-07-31 Univ Virginia Commonwealth Ligandos receptores de 5-ht6 selectivos
GB0016454D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
DE10063992A1 (de) 2000-12-21 2002-07-04 Max Planck Gesellschaft Tryptophan-Analoga in Proteinen, Peptiden und peptidischen Leitstrukturen
MXPA03005433A (es) * 2000-12-22 2003-09-10 Wyeth Corp Compuestos de heterociclilalquilindol o-azaindol como ligandos de 5-hidroxitriptamina-6.
US6730694B1 (en) * 2001-07-20 2004-05-04 Eli Lilly And Company sPLA2 inhibitors
KR100985140B1 (ko) * 2001-12-20 2010-10-05 와이어쓰 엘엘씨 5-하이드록시트립타민-6 리간드로서의 인돌릴알킬아민 유도체
DE60318716T2 (de) * 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
WO2005012311A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
CA2532382A1 (en) 2005-02-10
ES2290740T3 (es) 2008-02-16
EP1648904A1 (en) 2006-04-26
DE602004008474D1 (de) 2007-10-04
MXPA06000957A (es) 2006-03-30
US7220756B2 (en) 2007-05-22
US7041695B2 (en) 2006-05-09
PL1648904T3 (pl) 2008-01-31
CN100443487C (zh) 2008-12-17
DE602004008474T2 (de) 2008-05-15
AU2004261606A1 (en) 2005-02-10
WO2005012311A1 (en) 2005-02-10
DK1648904T3 (da) 2007-10-22
US20050038088A1 (en) 2005-02-17
US20060160878A1 (en) 2006-07-20
CN1826346A (zh) 2006-08-30
JP2007500701A (ja) 2007-01-18
ATE370955T1 (de) 2007-09-15
EP1648904B1 (en) 2007-08-22

Similar Documents

Publication Publication Date Title
SE0303180D0 (sv) Novel compounds
SE0201635D0 (sv) Novel compounds
SE0302232D0 (sv) Novel Compounds
CR8644A (es) Compuestos de imidazol para el tratamiento de transtornos neurodegenerativos
DK1853602T3 (da) Kemiske forbindelser
CY1108275T1 (el) Χημικες ενωσεις
EA200501504A1 (ru) Лиганды каннабиноидных рецепторов и их применение
CY1108738T1 (el) Θεραπευτικοι παραγοντες χρησιμοι για την αγωγη του πονου
MA31158B1 (fr) Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes
BR0206633A (pt) Derivados de 1-aril- ou 1-arilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6
UA92503C2 (ru) Соединения 5-(фенилизоксазолилэтокси)-триазол-3-ил-замещенного пиридина для лечения неврологических, психиатрических или болевых расстройств
DE602004024880D1 (de) Azetidincarboxamid-derivate zur verwendung zur behandlung von cb1-rezeptor-vermittelten krankheiten
BR0215151A (pt) Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6
BR0213094A (pt) Derivados de cromano como ligandos de 5-hidroxi-triptamina-6
ECSP034810A (es) Derivados heterociclilalcoxi-, -alquiltio- y - alquilaminobenzazol tales como ligandos 5-hidroxitriptamina-6
BRPI0418181A (pt) emprego de 2-aminotetralinas substituìdas para prevenção do tratamento de morbus parkinson
ECSP055964A (es) Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxitriptamina-6
ATE384039T1 (de) Indanderivate als muscarinrezeptoragonisten
ATE520651T1 (de) Substituierte phenylmethylbicyclocarbonsäureamidverbindungen
EA200601895A1 (ru) 3-(4-гетероарилциклогексиламино)циклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
MXPA06000701A (es) Compuestos de sulfonildihidrobencimidazolona como ligandos de 5-hidroxitriptamina-6.
DK1648904T3 (da) N-sulfonylheterocyclopyrrolalkylaminforbindelser som 5-hydroxytryptamin-6-ligander
DE602007011434D1 (de) 1h-indol-5-ylpiperazin-1-ylmethanonderivate
BR0209047A (pt) Derivados de heterociclilalcóxi-, -alquiltio- e -alquilaminobenzazol como ligantes de 5-hidroxitriptamina-6
TW200728258A (en) Novel compounds

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.