BRPI0413719A - agonistas alfa2 não-sedativos - Google Patents

agonistas alfa2 não-sedativos

Info

Publication number
BRPI0413719A
BRPI0413719A BRPI0413719-1A BRPI0413719A BRPI0413719A BR PI0413719 A BRPI0413719 A BR PI0413719A BR PI0413719 A BRPI0413719 A BR PI0413719A BR PI0413719 A BRPI0413719 A BR PI0413719A
Authority
BR
Brazil
Prior art keywords
sedative
stereoisomer
amide
ester
pharmaceutically acceptable
Prior art date
Application number
BRPI0413719-1A
Other languages
English (en)
Inventor
Ken Chow
Todd M Heidelbaugh
John E Donello
Daniel W Gil
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0413719A publication Critical patent/BRPI0413719A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"AGONISTAS ALFA~ 2~ NãO-SEDATIVOS". A presente invenção refere-se a um agonista seletivo <244>-2A/<244>-1A que inclui um composto representado pela Estrutura 1 ou um sal farmaceuticamente aceitável, éster, amida, estereoisómero ou mistura racêmica da mesma. A presente invenção ainda refere-se a uma composição farmacêutica que contém um veiculo farmacêutico e uma quantidade terapeuticamente eficaz de um agonista <244>-2A/<244>-1A que inclui um composto representado pela estrutura 1 ou um sal farmaceuticamente aceitável, éster, amida, estereoisómero ou mistura racêmica da mesma.
BRPI0413719-1A 2003-09-12 2004-08-20 agonistas alfa2 não-sedativos BRPI0413719A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50256203P 2003-09-12 2003-09-12
US10/891,953 US7141597B2 (en) 2003-09-12 2004-07-15 Nonsedating α-2 agonists
PCT/US2004/027134 WO2005034946A1 (en) 2003-09-12 2004-08-20 Nonsedating α-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione

Publications (1)

Publication Number Publication Date
BRPI0413719A true BRPI0413719A (pt) 2006-10-17

Family

ID=34278841

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413719-1A BRPI0413719A (pt) 2003-09-12 2004-08-20 agonistas alfa2 não-sedativos

Country Status (25)

Country Link
US (4) US7141597B2 (pt)
EP (2) EP1800679B1 (pt)
JP (1) JP4698591B2 (pt)
KR (1) KR101145046B1 (pt)
CN (1) CN100417379C (pt)
AT (2) ATE358479T1 (pt)
AU (1) AU2004279332B2 (pt)
BR (1) BRPI0413719A (pt)
CA (1) CA2537832C (pt)
CO (1) CO5680444A2 (pt)
CY (1) CY1107608T1 (pt)
DE (2) DE602004030051D1 (pt)
DK (2) DK1800679T3 (pt)
ES (1) ES2285522T3 (pt)
IL (1) IL173530A (pt)
MX (1) MXPA06002668A (pt)
NO (1) NO20060667L (pt)
NZ (1) NZ545181A (pt)
PL (2) PL1663206T3 (pt)
PT (1) PT1663206E (pt)
RU (1) RU2345987C2 (pt)
SI (1) SI1663206T1 (pt)
TW (1) TWI337999B (pt)
WO (1) WO2005034946A1 (pt)
ZA (1) ZA200601002B (pt)

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US7091232B2 (en) * 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20060293359A1 (en) * 2003-06-25 2006-12-28 Allergan, Inc. Methods and compositions for the treatment of diabetes
US20050059664A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Novel methods for identifying improved, non-sedating alpha-2 agonists
US7141597B2 (en) * 2003-09-12 2006-11-28 Allergan, Inc. Nonsedating α-2 agonists
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
WO2006036480A1 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
WO2006036497A2 (en) 2004-09-24 2006-04-06 Allergan, Inc. 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
US20090182026A1 (en) * 2005-06-29 2009-07-16 Allergan, Inc. Alpha 2 adrenergic agonists
US20070203144A1 (en) * 2006-01-17 2007-08-30 Allergan, Inc. Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals
BRPI0710674A2 (pt) * 2006-04-07 2011-08-23 Allergan Inc composições incluindo fármacos relativamente insolúveis em água/não umectáveis e métodos para usar as mesmas
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
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DK2160386T3 (da) 2007-05-23 2012-08-27 Allergan Inc Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser
DK2155733T3 (da) * 2007-05-23 2012-10-29 Allergan Inc Cykliske lactamer til behandling af glaukom eller forhøjet intraokulært tryk
US20110028559A1 (en) * 2007-07-06 2011-02-03 Fang Wenkui K Substituted fluoroethyl ureas as alpha 2 adrenergic agents
KR20100071990A (ko) * 2007-08-15 2010-06-29 알러간, 인코포레이티드 녹내장 및 통증과 같은 질환의 처치에 유용한 헤테로사이클 치환된 융합 카르보사이클
KR101642520B1 (ko) * 2007-08-15 2016-07-25 알러간, 인코포레이티드 아드레날린성 화합물
JP2010536780A (ja) * 2007-08-15 2010-12-02 アラーガン インコーポレイテッド 治療化合物
US20100216857A1 (en) * 2007-10-18 2010-08-26 Luhrs Lauren M B Method of treating motor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione
WO2009052073A2 (en) * 2007-10-18 2009-04-23 Allergan, Inc. Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists
US20110269805A1 (en) * 2007-10-18 2011-11-03 Gil Daniel W Method of treating sensorimotor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione
WO2009089448A1 (en) * 2008-01-11 2009-07-16 Allergan, Inc. Therapeutic disulfide compounds for treating pain and diabetes
US8420114B2 (en) * 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
US20090264477A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc., An Indiana Corporation Beta adrenergic receptor agonists for treatment of pain and/or inflammation
US20090263451A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
US8956641B2 (en) 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US9072727B2 (en) 2008-04-18 2015-07-07 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of degenerative disc disease
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Also Published As

Publication number Publication date
US20080176918A1 (en) 2008-07-24
US8022226B2 (en) 2011-09-20
ATE487477T1 (de) 2010-11-15
PT1663206E (pt) 2007-06-22
US7141597B2 (en) 2006-11-28
ES2285522T3 (es) 2007-11-16
AU2004279332A1 (en) 2005-04-21
ZA200601002B (en) 2007-04-25
KR20060119970A (ko) 2006-11-24
EP1663206B1 (en) 2007-04-04
MXPA06002668A (es) 2006-06-06
CA2537832C (en) 2012-01-24
CA2537832A1 (en) 2005-04-21
EP1663206A1 (en) 2006-06-07
ATE358479T1 (de) 2007-04-15
AU2004279332B2 (en) 2010-10-07
DE602004005720T2 (de) 2007-12-27
US20050059721A1 (en) 2005-03-17
DE602004030051D1 (de) 2010-12-23
CY1107608T1 (el) 2013-03-13
IL173530A (en) 2010-05-31
SI1663206T1 (sl) 2007-06-30
KR101145046B1 (ko) 2012-05-21
RU2345987C2 (ru) 2009-02-10
RU2006113600A (ru) 2007-11-10
NZ545181A (en) 2009-07-31
HK1092704A1 (en) 2007-02-16
JP4698591B2 (ja) 2011-06-08
CN100417379C (zh) 2008-09-10
US20110034525A1 (en) 2011-02-10
DK1800679T3 (da) 2011-02-07
IL173530A0 (en) 2006-07-05
EP1800679A3 (en) 2009-01-21
NO20060667L (no) 2006-04-06
EP1800679A2 (en) 2007-06-27
US7312238B2 (en) 2007-12-25
TWI337999B (en) 2011-03-01
DK1663206T3 (da) 2007-07-30
HK1104979A1 (en) 2008-02-01
CO5680444A2 (es) 2006-09-29
US20070004790A1 (en) 2007-01-04
EP1800679B1 (en) 2010-11-10
DE602004005720D1 (de) 2007-05-16
PL379561A1 (pl) 2006-10-16
WO2005034946A1 (en) 2005-04-21
PL1663206T3 (pl) 2007-08-31
TW200526591A (en) 2005-08-16
CN1849118A (zh) 2006-10-18
JP2007505111A (ja) 2007-03-08

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2267 DE 17/06/2014.