BRPI0413724A - processo para sìntese de 3-(3-flúor-4-hidroxifenil)-7-hidroxinaftonitrila - Google Patents

processo para sìntese de 3-(3-flúor-4-hidroxifenil)-7-hidroxinaftonitrila

Info

Publication number
BRPI0413724A
BRPI0413724A BRPI0413724-8A BRPI0413724A BRPI0413724A BR PI0413724 A BRPI0413724 A BR PI0413724A BR PI0413724 A BRPI0413724 A BR PI0413724A BR PI0413724 A BRPI0413724 A BR PI0413724A
Authority
BR
Brazil
Prior art keywords
hydroxyphenyl
fluoro
synthesis
hydroxynaphtitrile
hydroxynaphonitrile
Prior art date
Application number
BRPI0413724-8A
Other languages
English (en)
Inventor
Yanzhong Wu
Jianxin Ren
Mousumi Ghosh
Mahmut Levent
Karen Wiggins Sutherland
Panolil Raveendranath
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34312297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0413724(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0413724A publication Critical patent/BRPI0413724A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA SìNTESE DE 3-(3-FLúOR-4-HIDROXIFENIL)-7-HIDROXINAFTONITRILA". A presente invenção refere-se a um processo para preparação de um composto de fórmula I em que R~ 1~, é CN, F ou CI;R~ 2~ é H ou Br; e R~ 3~ e R~ 4~ são cada um independentemente H ou F. Estes compostos são úteis no tratamento de doenças inflamatórias crónicas, como artrite reumatóide.
BRPI0413724-8A 2003-09-09 2004-09-02 processo para sìntese de 3-(3-flúor-4-hidroxifenil)-7-hidroxinaftonitrila BRPI0413724A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50170003P 2003-09-09 2003-09-09
PCT/US2004/028645 WO2005026105A2 (en) 2003-09-09 2004-09-02 Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile

Publications (1)

Publication Number Publication Date
BRPI0413724A true BRPI0413724A (pt) 2006-10-17

Family

ID=34312297

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413724-8A BRPI0413724A (pt) 2003-09-09 2004-09-02 processo para sìntese de 3-(3-flúor-4-hidroxifenil)-7-hidroxinaftonitrila

Country Status (26)

Country Link
US (1) US7557237B2 (pt)
EP (1) EP1663929A2 (pt)
JP (1) JP2007505119A (pt)
KR (1) KR20060088876A (pt)
CN (1) CN1894185A (pt)
AR (1) AR045613A1 (pt)
AU (1) AU2004272571A1 (pt)
BR (1) BRPI0413724A (pt)
CA (1) CA2536768A1 (pt)
CO (1) CO5670331A2 (pt)
CR (1) CR8263A (pt)
EC (1) ECSP066416A (pt)
GT (1) GT200400179A (pt)
IL (1) IL173922A0 (pt)
MX (1) MXPA06002450A (pt)
NI (1) NI200600063A (pt)
NO (1) NO20061117L (pt)
NZ (1) NZ569134A (pt)
PA (1) PA8611901A1 (pt)
PE (1) PE20050947A1 (pt)
RU (1) RU2006105916A (pt)
SG (1) SG146646A1 (pt)
TW (1) TW200510280A (pt)
UA (1) UA84166C2 (pt)
WO (1) WO2005026105A2 (pt)
ZA (1) ZA200601986B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104114521A (zh) * 2012-02-17 2014-10-22 旭硝子株式会社 含氟芳香族化合物及其制造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554621A (en) 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
JP2001500155A (ja) 1996-09-13 2001-01-09 アルベマール・コーポレーシヨン ６―ブロモ―２―ナフトール及びその誘導体の製造
US5840996A (en) 1997-05-08 1998-11-24 Albemarle Corporation Production of brominated methoxynaphthalene compounds
TWI306450B (en) 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents

Also Published As

Publication number Publication date
CN1894185A (zh) 2007-01-10
EP1663929A2 (en) 2006-06-07
NI200600063A (es) 2006-06-21
JP2007505119A (ja) 2007-03-08
TW200510280A (en) 2005-03-16
SG146646A1 (en) 2008-10-30
US7557237B2 (en) 2009-07-07
CA2536768A1 (en) 2005-03-24
UA84166C2 (ru) 2008-09-25
GT200400179A (es) 2005-04-18
RU2006105916A (ru) 2007-10-20
NO20061117L (no) 2006-03-22
PA8611901A1 (es) 2006-06-02
IL173922A0 (en) 2006-07-05
MXPA06002450A (es) 2006-06-20
ZA200601986B (en) 2009-09-30
CR8263A (es) 2006-10-06
AU2004272571A1 (en) 2005-03-24
NZ569134A (en) 2009-10-30
US20050054870A1 (en) 2005-03-10
ECSP066416A (es) 2006-09-18
CO5670331A2 (es) 2006-08-31
WO2005026105A2 (en) 2005-03-24
AR045613A1 (es) 2005-11-02
PE20050947A1 (es) 2005-12-13
WO2005026105A3 (en) 2005-06-23
KR20060088876A (ko) 2006-08-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.