BRPI0516236A - sìntese assimétrica de derivados de diidrobenzofurano - Google Patents

sìntese assimétrica de derivados de diidrobenzofurano

Info

Publication number
BRPI0516236A
BRPI0516236A BRPI0516236-0A BRPI0516236A BRPI0516236A BR PI0516236 A BRPI0516236 A BR PI0516236A BR PI0516236 A BRPI0516236 A BR PI0516236A BR PI0516236 A BRPI0516236 A BR PI0516236A
Authority
BR
Brazil
Prior art keywords
asymmetric synthesis
derivatives
dihydrobenzofuran derivatives
dihydrobenzofuran
asymmetric
Prior art date
Application number
BRPI0516236-0A
Other languages
English (en)
Inventor
Dahui Zhou
Gary Paul Stack
Alexander V Gontcharov
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0516236A publication Critical patent/BRPI0516236A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SìNTESE ASSIMéTRICA DE DERIVADOS DE DIIDROBENZOFURANO. Esta invenção diz respeito a um processo para a preparação de derivados de benzofurano. Em alguns aspectos, estes compostos são da fórmula 1: em que cada um de R¹, R², R³, e R¬ 4¬ é como definido aqui.
BRPI0516236-0A 2004-10-21 2005-10-21 sìntese assimétrica de derivados de diidrobenzofurano BRPI0516236A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62102304P 2004-10-21 2004-10-21
PCT/US2005/037894 WO2006047288A2 (en) 2004-10-21 2005-10-21 Asymmetric synthesis of dihydrobenzofuran derivatives

Publications (1)

Publication Number Publication Date
BRPI0516236A true BRPI0516236A (pt) 2008-08-26

Family

ID=35965910

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516236-0A BRPI0516236A (pt) 2004-10-21 2005-10-21 sìntese assimétrica de derivados de diidrobenzofurano

Country Status (14)

Country Link
US (1) US20060089405A1 (pt)
EP (1) EP1802598A2 (pt)
JP (1) JP2008517929A (pt)
CN (1) CN101107238A (pt)
AR (1) AR053980A1 (pt)
AU (1) AU2005299757A1 (pt)
BR (1) BRPI0516236A (pt)
CA (1) CA2584775A1 (pt)
GT (1) GT200500296A (pt)
MX (1) MX2007004637A (pt)
PA (1) PA8650501A1 (pt)
PE (1) PE20061033A1 (pt)
TW (1) TW200619215A (pt)
WO (1) WO2006047288A2 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
CN101198323A (zh) * 2005-04-22 2008-06-11 惠氏公司 用于治疗或预防精神障碍的治疗组合
WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
TW200718692A (en) * 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
JP2008538577A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
CA2605117A1 (en) * 2005-04-22 2006-11-02 Wyeth Treatment of pain
GT200600159A (es) * 2005-04-22 2007-03-14 Derivados benzodioxano y benzodioxolano y usos de los mismos
CN101198322A (zh) * 2005-04-22 2008-06-11 惠氏公司 用于治疗或预防抑郁症的新治疗组合
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
JP2008538571A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
JP2008538576A (ja) * 2005-04-22 2008-10-30 ワイス クロマンおよびクロメン誘導体およびその使用
BRPI0609952A2 (pt) * 2005-04-24 2010-05-11 Wyeth Corp métodos para modular a função da bexiga
WO2007112065A2 (en) * 2006-03-24 2007-10-04 Wyeth Methods for treating cognitive and other disorders
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
GB2486631A (en) * 2010-12-01 2012-06-27 Univ Sheffield Phenol/quinone boronic acids/esters and method of preparation thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN109776465B (zh) * 2019-03-22 2023-06-06 国网湖南省电力有限公司 一种具有c2季碳中心的苯并二氢呋喃衍生物的合成方法
CN110283150A (zh) * 2019-07-12 2019-09-27 南开大学 一类手性二氢苯并呋喃的不对称合成方法
EP3878447A1 (en) 2020-03-11 2021-09-15 InterAx Biotech AG Beta adrenergic receptor antagonists
CN114560754A (zh) * 2022-02-25 2022-05-31 滁州学院 一种烷基醇的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100327264B1 (ko) * 1993-10-29 2002-07-02 요시히로 미와 인돌유도체,그의염및이를함유하는심질환치료제
WO1996001816A1 (en) * 1994-07-07 1996-01-25 Asahi Kasei Kogyo Kabushiki Kaisha Novel 2,3-dihydrobenzofuran derivative, process for producing the same, and use thereof
JPH09227562A (ja) * 1996-02-23 1997-09-02 Kowa Co インドール誘導体の製造法
JP2000007671A (ja) * 1998-06-25 2000-01-11 Asahi Chem Ind Co Ltd ２，３−ジヒドロベンゾフラン誘導体
JP2000080091A (ja) * 1998-06-26 2000-03-21 Asahi Chem Ind Co Ltd ２，３―ジヒドロベンゾフラン誘導体の製造方法
CN1564818A (zh) * 2001-10-05 2005-01-12 惠氏公司 2－羟甲基－苯并二氢吡喃的立体选择性合成方法
US7728155B2 (en) * 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
US7516224B2 (en) * 2004-10-21 2009-04-07 Cisco Technology, Inc. Pseudowire termination directly on a router
BRPI0610509A2 (pt) * 2005-04-22 2010-06-29 Wyeth Corp tratamento de dependência a drogas
GT200600159A (es) * 2005-04-22 2007-03-14 Derivados benzodioxano y benzodioxolano y usos de los mismos
JP2008538577A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
JP2008538576A (ja) * 2005-04-22 2008-10-30 ワイス クロマンおよびクロメン誘導体およびその使用
CA2605117A1 (en) * 2005-04-22 2006-11-02 Wyeth Treatment of pain
CN101198323A (zh) * 2005-04-22 2008-06-11 惠氏公司 用于治疗或预防精神障碍的治疗组合
CN101198322A (zh) * 2005-04-22 2008-06-11 惠氏公司 用于治疗或预防抑郁症的新治疗组合
TW200718692A (en) * 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
JP2008538571A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
BRPI0609952A2 (pt) * 2005-04-24 2010-05-11 Wyeth Corp métodos para modular a função da bexiga
US7593398B2 (en) * 2005-09-08 2009-09-22 Cisco Technology, Inc. Layer-two interworking applied to L2-L3 pseudowires

Also Published As

Publication number Publication date
AU2005299757A1 (en) 2006-05-04
CN101107238A (zh) 2008-01-16
PA8650501A1 (es) 2006-07-03
TW200619215A (en) 2006-06-16
CA2584775A1 (en) 2006-05-04
US20060089405A1 (en) 2006-04-27
PE20061033A1 (es) 2006-11-08
WO2006047288A2 (en) 2006-05-04
AR053980A1 (es) 2007-05-30
MX2007004637A (es) 2007-06-08
EP1802598A2 (en) 2007-07-04
WO2006047288A3 (en) 2007-03-15
JP2008517929A (ja) 2008-05-29
GT200500296A (es) 2006-10-02

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]