ECSP066416A - Procedimiento para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo - Google Patents

Procedimiento para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo

Info

Publication number
ECSP066416A
ECSP066416A EC2006006416A ECSP066416A ECSP066416A EC SP066416 A ECSP066416 A EC SP066416A EC 2006006416 A EC2006006416 A EC 2006006416A EC SP066416 A ECSP066416 A EC SP066416A EC SP066416 A ECSP066416 A EC SP066416A
Authority
EC
Ecuador
Prior art keywords
hydroxinaftonitrile
hydroxyphenyl
fluoro
synthesis
procedure
Prior art date
Application number
EC2006006416A
Other languages
English (en)
Inventor
Yanzhong Wu
Jianxin Ren
Mousumi Ghosh
Mahmut Levent
Karen Wiggins Sutherland
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34312297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066416(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066416A publication Critical patent/ECSP066416A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para hacer un compuesto de la fórmula I en donde R1 es CN, F o Cl; R2 es H o Br; y R3 y R4 son cada uno independientemente H o F. Estos compuestos son útiles en el tratamiento de enfermedades inflamatorias crónicas, tales como artritis reumatoide.
EC2006006416A 2003-09-09 2006-03-08 Procedimiento para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo ECSP066416A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50170003P 2003-09-09 2003-09-09

Publications (1)

Publication Number Publication Date
ECSP066416A true ECSP066416A (es) 2006-09-18

Family

ID=34312297

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006416A ECSP066416A (es) 2003-09-09 2006-03-08 Procedimiento para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo

Country Status (26)

Country Link
US (1) US7557237B2 (es)
EP (1) EP1663929A2 (es)
JP (1) JP2007505119A (es)
KR (1) KR20060088876A (es)
CN (1) CN1894185A (es)
AR (1) AR045613A1 (es)
AU (1) AU2004272571A1 (es)
BR (1) BRPI0413724A (es)
CA (1) CA2536768A1 (es)
CO (1) CO5670331A2 (es)
CR (1) CR8263A (es)
EC (1) ECSP066416A (es)
GT (1) GT200400179A (es)
IL (1) IL173922A0 (es)
MX (1) MXPA06002450A (es)
NI (1) NI200600063A (es)
NO (1) NO20061117L (es)
NZ (1) NZ569134A (es)
PA (1) PA8611901A1 (es)
PE (1) PE20050947A1 (es)
RU (1) RU2006105916A (es)
SG (1) SG146646A1 (es)
TW (1) TW200510280A (es)
UA (1) UA84166C2 (es)
WO (1) WO2005026105A2 (es)
ZA (1) ZA200601986B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013122174A1 (ja) 2012-02-17 2013-08-22 旭硝子株式会社 含フッ素芳香族化合物及びその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
EP0925270B1 (en) 1996-09-13 2001-01-10 Albemarle Corporation Production of 6-bromo-2-naphthol and derivatives
US5840996A (en) 1997-05-08 1998-11-24 Albemarle Corporation Production of brominated methoxynaphthalene compounds
TWI306450B (en) * 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents

Also Published As

Publication number Publication date
SG146646A1 (en) 2008-10-30
UA84166C2 (ru) 2008-09-25
PA8611901A1 (es) 2006-06-02
NZ569134A (en) 2009-10-30
KR20060088876A (ko) 2006-08-07
CO5670331A2 (es) 2006-08-31
BRPI0413724A (pt) 2006-10-17
TW200510280A (en) 2005-03-16
WO2005026105A3 (en) 2005-06-23
US7557237B2 (en) 2009-07-07
JP2007505119A (ja) 2007-03-08
EP1663929A2 (en) 2006-06-07
US20050054870A1 (en) 2005-03-10
AR045613A1 (es) 2005-11-02
CN1894185A (zh) 2007-01-10
ZA200601986B (en) 2009-09-30
NI200600063A (es) 2006-06-21
PE20050947A1 (es) 2005-12-13
RU2006105916A (ru) 2007-10-20
MXPA06002450A (es) 2006-06-20
CR8263A (es) 2006-10-06
GT200400179A (es) 2005-04-18
IL173922A0 (en) 2006-07-05
CA2536768A1 (en) 2005-03-24
AU2004272571A1 (en) 2005-03-24
WO2005026105A2 (en) 2005-03-24
NO20061117L (no) 2006-03-22

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