BRPI0413923A - composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo - Google Patents

composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo

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Publication number
BRPI0413923A
BRPI0413923A BRPI0413923-2A BRPI0413923A BRPI0413923A BR PI0413923 A BRPI0413923 A BR PI0413923A BR PI0413923 A BRPI0413923 A BR PI0413923A BR PI0413923 A BRPI0413923 A BR PI0413923A
Authority
BR
Brazil
Prior art keywords
edg
binding
compound
pharmaceutical use
compound capable
Prior art date
Application number
BRPI0413923-2A
Other languages
English (en)
Inventor
Shinji Nakade
Hirotaka Mizuno
Takeji Ono
Masashi Minami
Hiroshi Saga
Hiroshi Hagiya
Takaki Komiya
Himoru Habashita
Haruto Kurata
Kazuhiro Ohtsuki
Kensuke Kusumi
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Priority claimed from PCT/JP2004/012768 external-priority patent/WO2005020882A1/ja
Publication of BRPI0413923A publication Critical patent/BRPI0413923A/pt

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    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO CAPAZ DE LIGAR O RECEPTOR DE S1P E USO FARMACêUTICO DO MESMO". Um composto capaz de ligar os receptores de S1P (especialmente EDG-6, preferivelmente EDG-1 e EDG-6). Por exemplo, um composto da fórmula geral (I), o seu sal ou solvato, ou um pró-medicamento do mesmo é capaz de ligar os receptores de S1P (especialmente EDG-6, preferivelmente EDG-1 e EDG-6) e é, desse modo, útil na prevenção e/ou no tratamento de reação imunológica ao transplante, doença do enxerto versus hospedeiro, doença auto-imune, alergose, etc. (I) (em que o anel A é um grupo cíclico; o anel B é um grupo cíclico opcionalmente substituído; X é um espaçador com uma cadeia principal de 1 a 8 átomos, etc.; Y é um espaçador com uma cadeia principal de 1 a 10 átomos, etc. ; e n é 0 ou 1, desde que quando n for 0, m seja 1 e R¬ 1¬ seja um átomo de hidrogênio ou um substituinte, e que quando n for 1, m seja 0 ou um número inteiro de 1 a 7 e R¬ 1¬ seja um substituinte, em que quando m for 2 ou mais, os R¬ 1¬s podem ser idênticos ou diferentes um dos outros).
BRPI0413923-2A 2003-08-29 2004-08-27 composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo BRPI0413923A (pt)

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JP2003306088 2003-08-29
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JP2004198523 2004-07-05
PCT/JP2004/012768 WO2005020882A1 (ja) 2003-08-29 2004-08-27 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途

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JP5381959B2 (ja) 2014-01-08
AU2004268455A1 (en) 2005-03-10
KR20110140139A (ko) 2011-12-30
JP2011057688A (ja) 2011-03-24
KR101186386B1 (ko) 2012-09-26
CA2537093A1 (en) 2005-03-10
MXPA06002310A (es) 2006-05-25
JPWO2005020882A1 (ja) 2006-10-26
US20110020324A1 (en) 2011-01-27
US20140288034A1 (en) 2014-09-25
NZ545805A (en) 2009-12-24
US8791159B2 (en) 2014-07-29
ZA200602558B (en) 2006-12-27
JP4947406B2 (ja) 2012-06-06
NO20061372L (no) 2006-05-22
JP5817763B2 (ja) 2015-11-18
IL173973A (en) 2011-04-28
CA2824106A1 (en) 2005-03-10
EP1661881A2 (en) 2006-05-31
KR20060119919A (ko) 2006-11-24
IL173973A0 (en) 2006-07-05
CA2537093C (en) 2013-11-12
ES2527117T3 (es) 2015-01-20
AU2004268455B2 (en) 2009-12-17
EP1661881B1 (en) 2014-12-17
ES2754221T3 (es) 2020-04-16
JP2013151528A (ja) 2013-08-08
EP2883865B1 (en) 2019-09-25
WO2005020882A2 (ja) 2005-03-10
JP2014240432A (ja) 2014-12-25
WO2005020882A3 (ja) 2005-04-21
EP1661881A4 (en) 2008-02-27
EP2883865A1 (en) 2015-06-17
IL206888A0 (en) 2011-08-01
JP5928915B2 (ja) 2016-06-01

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