BRPI0414778A - 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer - Google Patents

6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer

Info

Publication number
BRPI0414778A
BRPI0414778A BRPI0414778-2A BRPI0414778A BRPI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A
Authority
BR
Brazil
Prior art keywords
imidazo
halo
aryl
pyrimidines
anticancer agents
Prior art date
Application number
BRPI0414778-2A
Other languages
English (en)
Inventor
Nan Zhang
Semiranis Ayral-Kaloustian
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0414778A publication Critical patent/BRPI0414778A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"6-ARIL-7-HALO-IMIDAZO¢1,2-a!PIRIMIDINAS COMO AGENTES ANTICáNCER". A presente invenção refere-se a certas 6-arila-7-halo-imidazo ¢1,2-a!pirimidinas ou sais farmaceuticamente aceitáveis das mesmas, e composições contendo os referidos compostos ou sais farmaceuticamente aceitáveis dos mesmos, em que os referidos compostos são agentes anticâncer úteis para o tratamento de câncer em mamíferos por promoção de polimerização de microtúbulo. Esta invenção também refere-se a um método de tratar ou inibir o desenvolvimento de células de tumores cancerosos e doenças associadas em um mamífero e também fornece um método para o tratamento ou prevenção de tumores cancerosos que expressam resistência à múltiplas drogas (MDR) ou são resistentes por causa da MDR, em um mamífero com necessidade do mesmo cujo método compreende administrar ao referido mamífero uma quantidade eficaz dos referidos compostos ou sais farmaceuticamente aceitáveis dos mesmos.
BRPI0414778-2A 2003-09-24 2004-09-17 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer BRPI0414778A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
BRPI0414778A true BRPI0414778A (pt) 2006-11-21

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414778-2A BRPI0414778A (pt) 2003-09-24 2004-09-17 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer

Country Status (14)

Country Link
US (2) US7285555B2 (pt)
EP (1) EP1684763B1 (pt)
JP (1) JP4695595B2 (pt)
CN (1) CN100486580C (pt)
AT (1) ATE398452T1 (pt)
AU (1) AU2004275728A1 (pt)
BR (1) BRPI0414778A (pt)
CA (1) CA2537520A1 (pt)
DE (1) DE602004014525D1 (pt)
DK (1) DK1684763T3 (pt)
ES (1) ES2308256T3 (pt)
MX (1) MXPA06002939A (pt)
PL (1) PL1684763T3 (pt)
WO (1) WO2005030218A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE385778T1 (de) * 1998-12-18 2008-03-15 Hadasit Med Res Service Verfahren zur verabreichung von einer verbindung an mehrfachresistente zellen
EA034598B1 (ru) 2005-12-23 2020-02-25 Ариад Фармасьютикалз, Инк. Применение бициклических гетероарильных соединений для лечения рака
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

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JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
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US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
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US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
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DK1341794T3 (da) 2000-12-06 2004-12-06 Wyeth Corp Fungicide 6-(2-trifluormethyl-phenyl)-triazolopyrimidiner
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Also Published As

Publication number Publication date
PL1684763T3 (pl) 2008-11-28
US7915266B2 (en) 2011-03-29
US7285555B2 (en) 2007-10-23
ATE398452T1 (de) 2008-07-15
ES2308256T3 (es) 2008-12-01
US20050065167A1 (en) 2005-03-24
CA2537520A1 (en) 2005-04-07
JP4695595B2 (ja) 2011-06-08
CN1856311A (zh) 2006-11-01
AU2004275728A1 (en) 2005-04-07
US20080255157A1 (en) 2008-10-16
WO2005030218A1 (en) 2005-04-07
JP2007506745A (ja) 2007-03-22
EP1684763A1 (en) 2006-08-02
DK1684763T3 (da) 2008-09-01
DE602004014525D1 (de) 2008-07-31
MXPA06002939A (es) 2006-05-31
EP1684763B1 (en) 2008-06-18
CN100486580C (zh) 2009-05-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.