BRPI0415273A - composto, sal de hidrocloreto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para inibir a reabsorção de norepinefrina em mamìferos e para tratar distúrbios associados com disfunção de norepinefrina em mamìferos, e, processo para a preparação de um composto - Google Patents

composto, sal de hidrocloreto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para inibir a reabsorção de norepinefrina em mamìferos e para tratar distúrbios associados com disfunção de norepinefrina em mamìferos, e, processo para a preparação de um composto

Info

Publication number
BRPI0415273A
BRPI0415273A BRPI0415273-5A BRPI0415273A BRPI0415273A BR PI0415273 A BRPI0415273 A BR PI0415273A BR PI0415273 A BRPI0415273 A BR PI0415273A BR PI0415273 A BRPI0415273 A BR PI0415273A
Authority
BR
Brazil
Prior art keywords
compound
mammals
norepinephrine
pharmaceutically acceptable
pharmaceutical composition
Prior art date
Application number
BRPI0415273-5A
Other languages
English (en)
Inventor
Gordon Iain Campbell
Manuel Javier Cases-Thomas
Teresa Man
Hel Ne Catherine Eugenie Rudyk
John Joseph Masters
Magnus Wilheim Walter
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29726235&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0415273(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0415273A publication Critical patent/BRPI0415273A/pt
Publication of BRPI0415273B1 publication Critical patent/BRPI0415273B1/pt
Publication of BRPI0415273B8 publication Critical patent/BRPI0415273B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, SAL DE HIDROCLORETO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO, MéTODOS PARA INIBIR A REABSORçãO DE NOREPINEFRINA EM MAMìFEROS E PARA TRATAR DISTURBIOS ASSOCIADOS COM DISFUNçãO DE NOREPINEFRINA EM MAMìFEROS, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". Compostos da fórmula geral (I) são inibidores da reabsorção de norepinefrina. Como tais, eles podem ser úteis para o tratamento de distúrbios do sistema nervoso central e/ou periférico.
BRPI0415273A 2003-11-10 2004-10-28 derivados de morfolina como inibidores de reabsorção de norepinefrina, seu sal de cloridrato, seu uso, seus intermediários e seu processo de preparação, e composição farmacêutica BRPI0415273B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0326148.4 2003-11-10
GBGB0326148.4A GB0326148D0 (en) 2003-11-10 2003-11-10 Morpholine derivatives
US53545904P 2004-01-09 2004-01-09
US60/535,459 2004-01-09
PCT/US2004/032771 WO2005047272A1 (en) 2003-11-10 2004-10-28 Morpholine derivatives as norepinephrine reuptake inhibitors

Publications (3)

Publication Number Publication Date
BRPI0415273A true BRPI0415273A (pt) 2006-12-19
BRPI0415273B1 BRPI0415273B1 (pt) 2019-04-30
BRPI0415273B8 BRPI0415273B8 (pt) 2021-05-25

Family

ID=29726235

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415273A BRPI0415273B8 (pt) 2003-11-10 2004-10-28 derivados de morfolina como inibidores de reabsorção de norepinefrina, seu sal de cloridrato, seu uso, seus intermediários e seu processo de preparação, e composição farmacêutica

Country Status (33)

Country Link
US (1) US7423037B2 (pt)
EP (2) EP1682523B1 (pt)
JP (1) JP4850068B2 (pt)
KR (1) KR100783855B1 (pt)
CN (1) CN1878762B (pt)
AR (1) AR046927A1 (pt)
AT (1) ATE478057T1 (pt)
AU (1) AU2004289616B2 (pt)
BR (1) BRPI0415273B8 (pt)
CA (1) CA2544649C (pt)
CR (1) CR8390A (pt)
CY (1) CY1110796T1 (pt)
DE (1) DE602004028750D1 (pt)
DK (1) DK1682523T3 (pt)
EA (1) EA009960B1 (pt)
EC (1) ECSP066555A (pt)
ES (1) ES2348872T3 (pt)
GB (1) GB0326148D0 (pt)
HR (1) HRP20100476T1 (pt)
IL (1) IL175365A (pt)
MA (1) MA28330A1 (pt)
MY (1) MY141048A (pt)
NO (1) NO336268B1 (pt)
NZ (1) NZ546067A (pt)
PE (1) PE20050491A1 (pt)
PL (1) PL1682523T3 (pt)
PT (1) PT1682523E (pt)
SI (1) SI1682523T1 (pt)
SV (1) SV2006001934A (pt)
TW (1) TWI339658B (pt)
UA (1) UA85198C2 (pt)
WO (1) WO2005047272A1 (pt)
ZA (1) ZA200603680B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060121178A (ko) * 2003-12-12 2006-11-28 일라이 릴리 앤드 캄파니 일과성 전신 열감, 충동 조절 장애 및 일반적인 의학상태로 인한 인격 변화 치료용 선택적 노르에피네프린재흡수 억제제
US8580776B2 (en) * 2007-07-10 2013-11-12 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating neurodegenerating diseases
RU2613633C1 (ru) * 2016-03-09 2017-03-21 федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФА Минздрава России) Хлорид 4-[(1Е)-1-(6-хлор-4-оксо-4Н-хромен-3-ил)-4-метилпент-1-ен-3-ил]морфолин-4-ия, способ его получения и противотуберкулезная активность
GB201915753D0 (en) * 2019-10-30 2019-12-11 Univ Warwick Alzheimer's disease

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GB895309A (en) 1959-11-18 1962-05-02 Res Lab Dr C Janssen Nv Pyrrolidine and piperidine derivatives
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PL193622B1 (pl) 1998-01-21 2007-02-28 Glaxo Group Ltd Farmaceutycznie czynny morfolinol, zawierająca gokompozycja oraz jego zastosowanie
EP1194152A4 (en) 1999-06-30 2002-11-06 Merck & Co Inc Links to SRC kinase inhibition
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JP2004277318A (ja) * 2003-03-14 2004-10-07 Dainippon Pharmaceut Co Ltd １−（１−置換カルボニル−４−ピペリジニルメチル）ピペリジン誘導体およびそれを含有する医薬組成物
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Also Published As

Publication number Publication date
NZ546067A (en) 2009-04-30
BRPI0415273B1 (pt) 2019-04-30
PL1682523T3 (pl) 2011-01-31
AR046927A1 (es) 2006-01-04
EP2223916A1 (en) 2010-09-01
TW200524885A (en) 2005-08-01
JP2007510720A (ja) 2007-04-26
ZA200603680B (en) 2007-07-25
NO336268B1 (no) 2015-07-06
AU2004289616A1 (en) 2005-05-26
EP1682523B1 (en) 2010-08-18
KR20060086408A (ko) 2006-07-31
EA200600945A1 (ru) 2006-10-27
DE602004028750D1 (de) 2010-09-30
JP4850068B2 (ja) 2012-01-11
US20070083046A1 (en) 2007-04-12
GB0326148D0 (en) 2003-12-17
DK1682523T3 (da) 2010-11-15
NO20062700L (no) 2006-08-08
BRPI0415273B8 (pt) 2021-05-25
IL175365A (en) 2011-02-28
CN1878762B (zh) 2010-10-27
HK1095135A1 (en) 2007-04-27
AU2004289616B2 (en) 2010-08-05
US7423037B2 (en) 2008-09-09
PE20050491A1 (es) 2005-08-24
HRP20100476T1 (hr) 2010-10-31
CY1110796T1 (el) 2015-06-10
CA2544649C (en) 2012-08-14
ES2348872T3 (es) 2010-12-16
EA009960B1 (ru) 2008-04-28
MA28330A1 (fr) 2006-12-01
KR100783855B1 (ko) 2007-12-10
CN1878762A (zh) 2006-12-13
CA2544649A1 (en) 2005-05-26
PT1682523E (pt) 2010-09-20
UA85198C2 (ru) 2009-01-12
CR8390A (es) 2007-12-07
IL175365A0 (en) 2006-09-05
EP1682523A1 (en) 2006-07-26
ECSP066555A (es) 2006-10-17
MY141048A (en) 2010-02-25
SI1682523T1 (sl) 2010-12-31
ATE478057T1 (de) 2010-09-15
WO2005047272A1 (en) 2005-05-26
TWI339658B (en) 2011-04-01
SV2006001934A (es) 2006-02-15

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