BRPI0415292A - derivados de alcanol e cicloalcanol-amina e métodos para seu uso - Google Patents

derivados de alcanol e cicloalcanol-amina e métodos para seu uso

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Publication number
BRPI0415292A
BRPI0415292A BRPI0415292-1A BRPI0415292A BRPI0415292A BR PI0415292 A BRPI0415292 A BR PI0415292A BR PI0415292 A BRPI0415292 A BR PI0415292A BR PI0415292 A BRPI0415292 A BR PI0415292A
Authority
BR
Brazil
Prior art keywords
methods
derivatives
amine derivatives
combinations
cycloalkanol
Prior art date
Application number
BRPI0415292-1A
Other languages
English (en)
Inventor
Eugene John Trybulski
Paige Erin Mahaney
Lori Danielle Krim
William Jay Moore
Joseph Peter Sabatucci
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0415292A publication Critical patent/BRPI0415292A/pt

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

"DERIVADOS DE ALCANOL E CICLOALCANOL-AMINA E MéTODOS PARA SEU USO". A presente invenção refere-se a derivados de alcanoíla e cicloalcanoil-amina, composições contendo esses derivados e métodos para seu uso para a prevenção e tratamento de condições melhoradas pela reabsorção de monoamina incluindo, inter alia, sintomas vasomotores (SVM), disfunção sexual, dístúrbios gastrointestinais e genitourinários, síndrome da fadiga crónica, síndrome da fibromialgia, distúrbios do sistema nervoso e suas combinações, particularmente aquelas condições selecionadas do grupo consistindo em distúrbio depressivo maior, sintomas vasomotores, estresse e incontinência urinária de urgência, fibromialgia, dor, neuropatia diabética e suas combinações.
BRPI0415292-1A 2003-10-14 2004-10-13 derivados de alcanol e cicloalcanol-amina e métodos para seu uso BRPI0415292A (pt)

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US51094203P 2003-10-14 2003-10-14
US56142204P 2004-04-12 2004-04-12
US56988404P 2004-05-11 2004-05-11
US10/962,880 US7491723B2 (en) 2003-10-14 2004-10-12 Alkanol and cycloalkanol-amine derivatives and methods of their use
PCT/US2004/033730 WO2005037207A2 (en) 2003-10-14 2004-10-13 Arylalkyl-piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms (vms)

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