BRPI0415681A - processo para a fabricação do sal de cálcio de ácido (e) -7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metil sulfonil) amino] pirimidin-5-il] (3r, 5s) 3,5-dihidroxihept-6-enóico, composto, processo para formação de sal de cálcio de bis ([ácido (e)-7-[-4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil)amino] pirimidin-5-il](3r, 5s)-3,5-dihidroxihept-6-enóico], e, uso de um composto - Google Patents

processo para a fabricação do sal de cálcio de ácido (e) -7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metil sulfonil) amino] pirimidin-5-il] (3r, 5s) 3,5-dihidroxihept-6-enóico, composto, processo para formação de sal de cálcio de bis ([ácido (e)-7-[-4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil)amino] pirimidin-5-il](3r, 5s)-3,5-dihidroxihept-6-enóico], e, uso de um composto

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Publication number
BRPI0415681A
BRPI0415681A BRPI0415681-1A BRPI0415681A BRPI0415681A BR PI0415681 A BRPI0415681 A BR PI0415681A BR PI0415681 A BRPI0415681 A BR PI0415681A BR PI0415681 A BRPI0415681 A BR PI0415681A
Authority
BR
Brazil
Prior art keywords
methyl
enoic
fluorophenyl
compound
amino
Prior art date
Application number
BRPI0415681-1A
Other languages
English (en)
Inventor
Tetsuo Okada
John Horbury
David Dermot Patrick Laffan
Original Assignee
Astazeneca Uk Ltd
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29595716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0415681(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astazeneca Uk Ltd, Shionogi & Co filed Critical Astazeneca Uk Ltd
Publication of BRPI0415681A publication Critical patent/BRPI0415681A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSO PARA A FABRICAçãO DO SAL DE CáLCIO DE áCIDO (E)-7-¢4-(4-FLUOROFENIL)-6-ISOPROPIL-2-¢METIL(METIL SULFONIL)AMINO!PIR1MIDIN-5-IL!(3R,5S)-3,5-DIHIDROXIHEPT 6-ENóICO, COMPOSTO, PROCESSO PARA FORMAçãO DE SAL DE CáLCIO DE BIS (¢áCIDO (E)-7-¢4-(4-FLUOROFENIL)-6-ISOPROPIL-2¢METIL(METILSULFON IL)AMINO!PIRIMIDIN-5-IL!(3R,5S)-3,5DIHIDROXIHEPT-6-ENóIC O!, E, USO DE UM COMPOSTO". Processo para a fabricação de sal de cálcio de ácido (E)-7-¢4(4-fluorofenil)-6-isopropil-2-¢metil(metilsulfonil)amino!pirimidin-5 il!(3R,5S)-3,5-dihidroxihept-6-enóico, utilizável como um inibidor de HMGCoA reductase, a partir de um composto de fórmula (7), em que A é um grupo de proteção acetal ou cetal e R é alquila, via compostos cristalinos isolados de fórmula (8) ou fórmula (10) é descrito. Os intermediários cristalinos de fórmulas 7, 8 e 10 são também descritos.
BRPI0415681-1A 2003-10-24 2004-10-22 processo para a fabricação do sal de cálcio de ácido (e) -7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metil sulfonil) amino] pirimidin-5-il] (3r, 5s) 3,5-dihidroxihept-6-enóico, composto, processo para formação de sal de cálcio de bis ([ácido (e)-7-[-4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil)amino] pirimidin-5-il](3r, 5s)-3,5-dihidroxihept-6-enóico], e, uso de um composto BRPI0415681A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0324791.3A GB0324791D0 (en) 2003-10-24 2003-10-24 Chemical process
PCT/GB2004/004481 WO2005042522A1 (en) 2003-10-24 2004-10-22 Process for the manufacture of the calcium salt of rosuvatatin (e)-7-`4- (4-fluorophenyl) -6-isopropyl-2-`methyl (methylsulfonyl) amino ! pyrimidin -5-yl ! (3r, 5s) -3, 5-dihydroxyhept-6-enoic acid and crystalline intermediates thereof

Publications (1)

Publication Number Publication Date
BRPI0415681A true BRPI0415681A (pt) 2006-12-19

Family

ID=29595716

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415681-1A BRPI0415681A (pt) 2003-10-24 2004-10-22 processo para a fabricação do sal de cálcio de ácido (e) -7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metil sulfonil) amino] pirimidin-5-il] (3r, 5s) 3,5-dihidroxihept-6-enóico, composto, processo para formação de sal de cálcio de bis ([ácido (e)-7-[-4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil)amino] pirimidin-5-il](3r, 5s)-3,5-dihidroxihept-6-enóico], e, uso de um composto

Country Status (28)

Country Link
US (2) US20070255060A1 (pt)
EP (2) EP1682536B1 (pt)
JP (3) JP2007509119A (pt)
KR (1) KR20060132829A (pt)
CN (2) CN101654453B (pt)
AR (1) AR046191A1 (pt)
AU (1) AU2004285750B2 (pt)
BR (1) BRPI0415681A (pt)
CA (1) CA2543358A1 (pt)
CY (1) CY1114145T1 (pt)
DK (1) DK1682536T3 (pt)
ES (1) ES2404693T3 (pt)
GB (1) GB0324791D0 (pt)
IL (1) IL175086A0 (pt)
IS (1) IS8478A (pt)
MY (1) MY146002A (pt)
NO (1) NO20062263L (pt)
NZ (1) NZ547094A (pt)
PL (1) PL1682536T3 (pt)
PT (1) PT1682536E (pt)
RU (1) RU2372349C2 (pt)
SA (1) SA04250425B1 (pt)
SI (1) SI1682536T1 (pt)
TW (1) TWI344957B (pt)
UA (1) UA83076C2 (pt)
UY (1) UY28577A1 (pt)
WO (1) WO2005042522A1 (pt)
ZA (1) ZA200603173B (pt)

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UA83076C2 (en) 2008-06-10
IL175086A0 (en) 2006-08-20
US9371291B2 (en) 2016-06-21
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DK1682536T3 (da) 2013-05-06
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CN1898233A (zh) 2007-01-17
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