BRPI0415838A - compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncer - Google Patents
compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncerInfo
- Publication number
- BRPI0415838A BRPI0415838A BRPI0415838-5A BRPI0415838A BRPI0415838A BR PI0415838 A BRPI0415838 A BR PI0415838A BR PI0415838 A BRPI0415838 A BR PI0415838A BR PI0415838 A BRPI0415838 A BR PI0415838A
- Authority
- BR
- Brazil
- Prior art keywords
- cancer
- ethenyl
- oxazole
- phenyl
- compounds
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 150000003557 thiazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTOS DE 2-(E)-2- (FENIL) ETENIL-4- (ARILALCOXI)-OXAZOLA OU-TIAZOLA COMO INIBIDORES DE HER-2 TIROSINA QUINASES E SEU USO NO TRATAMENTO DE CáNCER". São objetos da presente invenção os compostos de fórmula (I), seus sais aceitáveis do ponto de vista farmacêutico, formas enancioméricas dos mesmos, diastereoisómeros e racematos, a preparação dos compostos acima mencionados, medicamentos contendo os mesmos e sua fabricação, bem como o uso dos compostos mencionados no controle ou prevenção de doenças tais como câncer.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03024399 | 2003-10-24 | ||
| EP03024694 | 2003-10-28 | ||
| EP03025948 | 2003-11-13 | ||
| PCT/EP2004/011943 WO2005040158A1 (en) | 2003-10-24 | 2004-10-22 | 1-′(e)-2-(phenyl) ethenyl-4-(arylalkoxy)-oxazole or - thiazole compounds as her-2 tyrosine kinases inhibitors and their use in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0415838A true BRPI0415838A (pt) | 2007-01-02 |
Family
ID=34527387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0415838-5A BRPI0415838A (pt) | 2003-10-24 | 2004-10-22 | compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7259262B2 (pt) |
| EP (1) | EP1680417A1 (pt) |
| JP (1) | JP2007509102A (pt) |
| KR (1) | KR100797434B1 (pt) |
| AU (1) | AU2004283874A1 (pt) |
| BR (1) | BRPI0415838A (pt) |
| CA (1) | CA2539720A1 (pt) |
| MX (1) | MXPA06004404A (pt) |
| WO (1) | WO2005040158A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200531688A (en) * | 2004-03-05 | 2005-10-01 | Hoffmann La Roche | Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents |
| JP4982367B2 (ja) * | 2004-07-26 | 2012-07-25 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤としてのオキサゾール誘導体、製造及び治療的使用 |
| WO2012094451A1 (en) * | 2011-01-06 | 2012-07-12 | Beta Pharma Canada Inc. | Novel ureas for the treatment and prevention of cancer |
| WO2017109793A1 (en) * | 2015-12-21 | 2017-06-29 | Council Of Scientific & Industrial Research | Novel 1,2,3 triazole-thiazole compounds, process for preparation and use thereof |
| CN117820251B (zh) * | 2024-03-01 | 2024-05-03 | 南京桦冠生物技术有限公司 | 双α-酮酸酰胺类化合物及其组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003505A2 (en) | 1996-07-19 | 1998-01-29 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| PE20011178A1 (es) | 2000-04-07 | 2001-11-19 | Takeda Chemical Industries Ltd | Compuestos heterociclicos y su produccion |
| HUP0400683A2 (hu) | 2000-12-11 | 2004-06-28 | Takeda Chemical Industries, Ltd. | HER2 inhibitort tartalmazó fokozott felszívódású gyógyászati készítmény |
| US6984653B2 (en) | 2001-10-05 | 2006-01-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof |
| AU2003203170A1 (en) | 2002-01-17 | 2003-07-30 | Takeda Chemical Industries, Ltd. | Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof |
| TW200612914A (en) * | 2004-03-05 | 2006-05-01 | Hoffmann La Roche | Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents |
-
2004
- 2004-10-15 US US10/965,996 patent/US7259262B2/en not_active Expired - Fee Related
- 2004-10-22 BR BRPI0415838-5A patent/BRPI0415838A/pt not_active IP Right Cessation
- 2004-10-22 JP JP2006536053A patent/JP2007509102A/ja active Pending
- 2004-10-22 AU AU2004283874A patent/AU2004283874A1/en not_active Abandoned
- 2004-10-22 EP EP04790740A patent/EP1680417A1/en not_active Withdrawn
- 2004-10-22 MX MXPA06004404A patent/MXPA06004404A/es active IP Right Grant
- 2004-10-22 KR KR1020067004941A patent/KR100797434B1/ko not_active Expired - Fee Related
- 2004-10-22 CA CA002539720A patent/CA2539720A1/en not_active Abandoned
- 2004-10-22 WO PCT/EP2004/011943 patent/WO2005040158A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06004404A (es) | 2006-06-14 |
| JP2007509102A (ja) | 2007-04-12 |
| US7259262B2 (en) | 2007-08-21 |
| KR20060057009A (ko) | 2006-05-25 |
| CA2539720A1 (en) | 2005-05-06 |
| KR100797434B1 (ko) | 2008-01-23 |
| WO2005040158A1 (en) | 2005-05-06 |
| AU2004283874A1 (en) | 2005-05-06 |
| US20050124670A1 (en) | 2005-06-09 |
| EP1680417A1 (en) | 2006-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |