BRPI0415851A - utilizações médicas de compostos que apresentam atividade antagonìstica de cb1 e tratamento de combinação envolvendo os referidos compostos - Google Patents

utilizações médicas de compostos que apresentam atividade antagonìstica de cb1 e tratamento de combinação envolvendo os referidos compostos

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Publication number
BRPI0415851A
BRPI0415851A BRPI0415851-2A BRPI0415851A BRPI0415851A BR PI0415851 A BRPI0415851 A BR PI0415851A BR PI0415851 A BRPI0415851 A BR PI0415851A BR PI0415851 A BRPI0415851 A BR PI0415851A
Authority
BR
Brazil
Prior art keywords
compounds
treatment
prophylaxis
young patients
combination
Prior art date
Application number
BRPI0415851-2A
Other languages
English (en)
Inventor
Jochen Antel
Peter-Colin Gregory
Harald Waldeck
Guenter Krause
Josephus Hubertus Maria Lange
Chris Kruse
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0415851A publication Critical patent/BRPI0415851A/pt

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

"UTILIZAçõES MéDICAS DE COMPOSTOS QUE APRESENTAM ATIVIDADE ANTAGONìSTICA DE CB~ 1~ E TRATAMENTO DE COMBINAçãO ENVOLVENDO OS REFERIDOS COMPOSTOS". A presente invenção refere-se a uma nova utilização clínica de compostos com atividade no receptor CB~ 1~ selecionados a partir do grupo de derivados de 4,5-di-hidro-1H-pirazol, derivados de 1H-Imidazol, derivados de tiazol e/ou derivados de 1H-1,2,4-triazol-3-carboxamida, como cada um definido na descrição, ou de um seu pró-fármaco, um seu tautómero ou um seu sal, na preparação de medicamentos para o tratamento e/ou profilaxia de doenças relacionadas com o receptor CB~ 1~ em doentes jovens e/ou para o tratamento e/ou profilaxia da obesidade induzida por fármaco em doentes jovens, assim como em adolescentes. Além disso, a invenção refere-se à utilização dos referidos compostos com atividade no receptor CB~ 1~ em combinação com inibidores de lipase. Os referidos compostos são particularmente adequados em combinação com inibidores de lipase na preparação de medicamentos para o tratamento e/ou profilaxia da obesidade em pacientes adolescentes ou jovens e/ou para o tratamento e/ou profilaxia da obesidade induzida por fármaco em doentes jovens assim como em adolescentes. Os inibidores de lipase preferidos são orlistato, panclicinas, ATL-962 e/ou lipstatina.
BRPI0415851-2A 2003-10-24 2004-10-22 utilizações médicas de compostos que apresentam atividade antagonìstica de cb1 e tratamento de combinação envolvendo os referidos compostos BRPI0415851A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103961 2003-10-24
EP03103967 2003-10-27
PCT/EP2004/052639 WO2005039550A2 (en) 2003-10-24 2004-10-22 Novel medical uses of compounds showing cb1-antagonistic activity and combination treatment involving said compounds

Publications (1)

Publication Number Publication Date
BRPI0415851A true BRPI0415851A (pt) 2007-01-02

Family

ID=34524748

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415851-2A BRPI0415851A (pt) 2003-10-24 2004-10-22 utilizações médicas de compostos que apresentam atividade antagonìstica de cb1 e tratamento de combinação envolvendo os referidos compostos

Country Status (8)

Country Link
EP (1) EP1753413A2 (pt)
JP (1) JP2007513872A (pt)
AU (1) AU2004283056A1 (pt)
BR (1) BRPI0415851A (pt)
CA (1) CA2543338A1 (pt)
MX (1) MXPA06004434A (pt)
RU (1) RU2006117627A (pt)
WO (1) WO2005039550A2 (pt)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
WO2004058145A2 (en) 2002-12-19 2004-07-15 Merck & Co., Inc. Substituted amides
AR046132A1 (es) * 2003-10-24 2005-11-23 Solvay Pharm Gmbh Composicin farmaceutica que contiene al menos un compuesto con actividad de receptor de cb1, o un profarmaco , tautomero o sal del mismo, como componente activo adecuado para el tratamiento y/o profilaxis de enfermedades relacionadas con el receptor cb1 en pacientes juveniles y/o para el tratamiento
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
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