BRPI0416041A - locus da micolactona: uma linha de montagem para produção de novos policetìdeos com usos terapêutico e profilático - Google Patents
locus da micolactona: uma linha de montagem para produção de novos policetìdeos com usos terapêutico e profiláticoInfo
- Publication number
- BRPI0416041A BRPI0416041A BRPI0416041-0A BRPI0416041A BRPI0416041A BR PI0416041 A BRPI0416041 A BR PI0416041A BR PI0416041 A BRPI0416041 A BR PI0416041A BR PI0416041 A BRPI0416041 A BR PI0416041A
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptides
- production
- micolactone
- locus
- assembly line
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229930001119 polyketide Natural products 0.000 title abstract 2
- 125000000830 polyketide group Chemical group 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000000069 prophylactic effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108010030975 Polyketide Synthases Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000187917 Mycobacterium ulcerans Species 0.000 abstract 1
- WKTLNJXZVDLRTJ-QRRXZRELSA-N Mycolactone Chemical compound C[C@@H](O)C[C@@H](O)[C@H](C)\C=C(/C)C[C@H](C)[C@H]1C\C=C(C)\C[C@H](C)[C@@H](OC(=O)\C=C\C(\C)=C\C(\C)=C\C=C\C(\C)=C\[C@H](O)[C@@H](O)C[C@H](C)O)CCCC(=O)O1 WKTLNJXZVDLRTJ-QRRXZRELSA-N 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229930185122 mycolactone Natural products 0.000 abstract 1
- WKTLNJXZVDLRTJ-PPVVEJQLSA-N mycolactone A Natural products CC(O)CC(O)C(C)C=C(/C)CC(C)C1CC=C(/C)CC(C)C(CCCC(=O)O1)OC(=O)C=CC(=C/C(=C/C=C/C(=C/C(O)C(O)CC(C)O)/C)/C)C WKTLNJXZVDLRTJ-PPVVEJQLSA-N 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"LOCUS DA MICOLACTONA: UMA LINHA DE MONTAGEM PARA PRODUçãO DE NOVOS POLICETIDEOS COM USOS TERAPêUTICO E PROFILáTICO". A presente invenção refere-se a plasmídeo virulento de Mycobacterium ulceran, pMUM001, e particularmente a um agrupamento de genes carreados por este plasmídeo, que codifica policetideo sintases (PKSs) e enzimas modificadoras de policetídeo, necessárias e suficientes para biossíntese de micolactona. Mais particularmente, esta invenção é direcionada a novos polipeptídeos purificados ou isolados, o polinculeotídeos codificando tais polipeptídeos, processos para produção de tais polipeptídeos, anticorpos gerados, contra estes polipeptídeos, o uso de tais polinucleotídeos e polipeptídeos em métodos de diagnóstico, kits, vacinas, terapia e para a produção de derivados de micolactona ou novos policetídeos por síntese combinatorial.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51986403P | 2003-11-14 | 2003-11-14 | |
| PCT/IB2004/003999 WO2005047509A2 (en) | 2003-11-14 | 2004-11-15 | The mycolactone locus : an assembly line for producing novel polyketides, with therapeutic and prophylatic uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416041A true BRPI0416041A (pt) | 2007-01-02 |
Family
ID=35732788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416041-0A BRPI0416041A (pt) | 2003-11-14 | 2004-11-15 | locus da micolactona: uma linha de montagem para produção de novos policetìdeos com usos terapêutico e profilático |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060024806A1 (pt) |
| EP (1) | EP1704235A2 (pt) |
| JP (1) | JP2007511218A (pt) |
| BR (1) | BRPI0416041A (pt) |
| CA (1) | CA2546243A1 (pt) |
| NO (1) | NO20062790L (pt) |
| WO (1) | WO2005047509A2 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2015770B1 (en) | 2006-05-09 | 2012-09-26 | Novo Nordisk A/S | Insulin derivative |
| ITRM20100411A1 (it) * | 2010-07-23 | 2012-01-24 | Massimo Amicosante | Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino. |
| PL3302032T3 (pl) | 2015-06-06 | 2022-06-20 | Dsm Ip Assets B.V. | Wytwarzanie wielonienasyconych kwasów tłuszczowych (PUFA) z zastosowaniem nowej, modularnej syntazy kwasu dokozaheksaenowego (DHA) |
| CN113265354B (zh) * | 2021-05-19 | 2022-08-26 | 科润生科技发展有限公司 | 同时降解黄曲霉毒素和呕吐毒素的娄彻氏链霉菌及其制剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003501423A (ja) * | 1999-06-03 | 2003-01-14 | アメリカ合衆国 | マイコラクトンおよび関連化合物、組成物、ならびに使用方法 |
| WO2001019993A2 (en) * | 1999-09-17 | 2001-03-22 | University Of Maryland, Baltimore | Virulence genes of m. marinum and m. tuberculosis |
| WO2002012533A2 (en) * | 2000-08-03 | 2002-02-14 | Kosan Biosciences, Inc. | Fermentation and purification of mycolactones |
-
2004
- 2004-11-15 BR BRPI0416041-0A patent/BRPI0416041A/pt not_active Application Discontinuation
- 2004-11-15 CA CA002546243A patent/CA2546243A1/en not_active Abandoned
- 2004-11-15 EP EP04799035A patent/EP1704235A2/en not_active Withdrawn
- 2004-11-15 JP JP2006538998A patent/JP2007511218A/ja active Pending
- 2004-11-15 WO PCT/IB2004/003999 patent/WO2005047509A2/en not_active Ceased
-
2005
- 2005-07-07 US US11/175,689 patent/US20060024806A1/en not_active Abandoned
-
2006
- 2006-06-14 NO NO20062790A patent/NO20062790L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1704235A2 (en) | 2006-09-27 |
| CA2546243A1 (en) | 2005-05-26 |
| NO20062790L (no) | 2006-08-14 |
| JP2007511218A (ja) | 2007-05-10 |
| WO2005047509A8 (en) | 2006-02-16 |
| WO2005047509A3 (en) | 2006-07-20 |
| US20060024806A1 (en) | 2006-02-02 |
| WO2005047509A2 (en) | 2005-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |