BRPI0416492A - forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória - Google Patents

forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória

Info

Publication number
BRPI0416492A
BRPI0416492A BRPI0416492-0A BRPI0416492A BRPI0416492A BR PI0416492 A BRPI0416492 A BR PI0416492A BR PI0416492 A BRPI0416492 A BR PI0416492A BR PI0416492 A BRPI0416492 A BR PI0416492A
Authority
BR
Brazil
Prior art keywords
substance
active ingredient
influences
matrix
distribution
Prior art date
Application number
BRPI0416492-0A
Other languages
English (en)
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Original Assignee
R Hm Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Hm Gmbh & Co Kg filed Critical R Hm Gmbh & Co Kg
Publication of BRPI0416492A publication Critical patent/BRPI0416492A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"FORMA FARMACêUTICA MULTICAMADAS COM UMA MATRIZ A QUAL INFLUENCIA A DISTRIBUIçãO DE UMA SUBSTáNCIA MODULATóRIA". A presente invenção refere-se a uma forma farmacêutica de múltiplas camadas para liberação controlada de ingrediente ativo, essencialmente compreendendo: a) Opcionalmente um núcleo neutro (não-análogo), b) Uma camada de controle interna compreendendo uma substância com um efeito modulador, a qual está embebida numa matriz a qual influencia a distribuição da substância modulatória e a qual compreende polímeros, ceras, resinas e/ou proteínas farmaceuticamente usáveis, e onde apropriado um ingrediente ativo, c) Uma camada de ingrediente ativo compreendendo um ingrediente farmaceuticamente ativo e, onde apropriado, uma substância com um efeito modulador, d) Uma camada de controle externa compreendendo pelo menos 60% em peso de uma ou uma mistura de uma pluralidade de copolímeros de (met)acrilato composta de 98 a 85 de ésteres de ácido (met)acrílico de alquiIa C~ 1~ a C~ 4~ e de 2 a 15% em peso de monómeros de metacrilato com um grupo quaternário de amónio no radical alquila e, onde apropriado, polímeros adicionais farmaceuticamente usáveis insolúveis em água, onde as camadas podem adicionalmente e de uma forma conhecida per se compreender excipientes farmaceuticamente usuais.
BRPI0416492-0A 2003-11-13 2004-09-15 forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória BRPI0416492A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353196A DE10353196A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
PCT/EP2004/010300 WO2005046561A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix

Publications (1)

Publication Number Publication Date
BRPI0416492A true BRPI0416492A (pt) 2007-03-13

Family

ID=34585091

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416492-0A BRPI0416492A (pt) 2003-11-13 2004-09-15 forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória

Country Status (10)

Country Link
US (1) US20070042045A1 (pt)
EP (1) EP1682094A2 (pt)
JP (1) JP2007510677A (pt)
KR (1) KR20060113728A (pt)
CN (1) CN1863516A (pt)
BR (1) BRPI0416492A (pt)
CA (1) CA2544487A1 (pt)
DE (1) DE10353196A1 (pt)
IL (1) IL175562A0 (pt)
WO (1) WO2005046561A2 (pt)

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WO2010096732A1 (en) * 2009-02-20 2010-08-26 University Of Medicine And Dentistry Of New Jersey Combination therapy to improve drug efficiency
KR101317592B1 (ko) 2009-10-28 2013-10-15 씨제이제일제당 (주) 프레가발린, 폴리에틸렌옥사이드 및 폴리비닐알코올-폴리에틸렌글리콜 그라프트 공중합체를 함유하는 위체류형 서방성 제제
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Also Published As

Publication number Publication date
DE10353196A1 (de) 2005-06-16
WO2005046561A3 (de) 2006-03-16
EP1682094A2 (de) 2006-07-26
KR20060113728A (ko) 2006-11-02
CN1863516A (zh) 2006-11-15
JP2007510677A (ja) 2007-04-26
CA2544487A1 (en) 2005-05-26
US20070042045A1 (en) 2007-02-22
WO2005046561A2 (de) 2005-05-26
IL175562A0 (en) 2008-04-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.