BRPI0416492A - forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória - Google Patents

forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória

Info

Publication number
BRPI0416492A
BRPI0416492A BRPI0416492-0A BRPI0416492A BRPI0416492A BR PI0416492 A BRPI0416492 A BR PI0416492A BR PI0416492 A BRPI0416492 A BR PI0416492A BR PI0416492 A BRPI0416492 A BR PI0416492A
Authority
BR
Brazil
Prior art keywords
substance
active ingredient
influences
matrix
distribution
Prior art date
Application number
BRPI0416492-0A
Other languages
English (en)
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Original Assignee
R Hm Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Hm Gmbh & Co Kg filed Critical R Hm Gmbh & Co Kg
Publication of BRPI0416492A publication Critical patent/BRPI0416492A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"FORMA FARMACêUTICA MULTICAMADAS COM UMA MATRIZ A QUAL INFLUENCIA A DISTRIBUIçãO DE UMA SUBSTáNCIA MODULATóRIA". A presente invenção refere-se a uma forma farmacêutica de múltiplas camadas para liberação controlada de ingrediente ativo, essencialmente compreendendo: a) Opcionalmente um núcleo neutro (não-análogo), b) Uma camada de controle interna compreendendo uma substância com um efeito modulador, a qual está embebida numa matriz a qual influencia a distribuição da substância modulatória e a qual compreende polímeros, ceras, resinas e/ou proteínas farmaceuticamente usáveis, e onde apropriado um ingrediente ativo, c) Uma camada de ingrediente ativo compreendendo um ingrediente farmaceuticamente ativo e, onde apropriado, uma substância com um efeito modulador, d) Uma camada de controle externa compreendendo pelo menos 60% em peso de uma ou uma mistura de uma pluralidade de copolímeros de (met)acrilato composta de 98 a 85 de ésteres de ácido (met)acrílico de alquiIa C~ 1~ a C~ 4~ e de 2 a 15% em peso de monómeros de metacrilato com um grupo quaternário de amónio no radical alquila e, onde apropriado, polímeros adicionais farmaceuticamente usáveis insolúveis em água, onde as camadas podem adicionalmente e de uma forma conhecida per se compreender excipientes farmaceuticamente usuais.
BRPI0416492-0A 2003-11-13 2004-09-15 forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória BRPI0416492A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353196A DE10353196A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
PCT/EP2004/010300 WO2005046561A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix

Publications (1)

Publication Number Publication Date
BRPI0416492A true BRPI0416492A (pt) 2007-03-13

Family

ID=34585091

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416492-0A BRPI0416492A (pt) 2003-11-13 2004-09-15 forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória

Country Status (10)

Country Link
US (1) US20070042045A1 (pt)
EP (1) EP1682094A2 (pt)
JP (1) JP2007510677A (pt)
KR (1) KR20060113728A (pt)
CN (1) CN1863516A (pt)
BR (1) BRPI0416492A (pt)
CA (1) CA2544487A1 (pt)
DE (1) DE10353196A1 (pt)
IL (1) IL175562A0 (pt)
WO (1) WO2005046561A2 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2283842T1 (sl) 2000-02-08 2015-07-31 Euro-Celtique S.A. Oralne formulacije opioidnih agonistov, varne pred zlorabo
SI1551372T1 (en) 2002-09-20 2018-08-31 Alpharma Pharmaceuticals Llc SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
DE102004036437A1 (de) 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005007059A1 (de) 2005-02-15 2006-08-24 Röhm GmbH & Co. KG Teilneutralisiertes anionisches (Meth)acrylat-Copolymer
WO2006102965A1 (en) * 2005-03-29 2006-10-05 Evonik Röhm Gmbh Multiparticulate pharmaceutical form comprising pellets with a matrix which influences the delivery of a modulatory substance
CA2600282A1 (en) * 2005-03-29 2006-10-05 Roehm Gmbh Multiparticulate pharmaceutical form comprising pellets with a substance having a modular effect in relation to active ingredient release
KR101320016B1 (ko) * 2005-12-14 2013-10-29 주식회사 대웅 안정화된 코엔자임ｑ10, 종합 비타민 및 미네랄 성분을함유하는 복합제제
DE102006006532B4 (de) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
ITMI20061024A1 (it) * 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
SI2484346T1 (sl) 2006-06-19 2017-05-31 Alpharma Pharmaceuticals Llc Farmacevtski sestavki
DE102006035549A1 (de) * 2006-07-27 2008-01-31 Evonik Röhm Gmbh Arzneiform mit mindestens zweischichtiger Trennschicht
GB0618879D0 (en) * 2006-09-26 2006-11-01 Zysis Ltd Pharmaceutical compositions
AU2008288105A1 (en) * 2007-03-29 2009-02-19 Panacea Biotec Limited. Modified dosage forms of tacrolimus
US20100266645A1 (en) * 2007-12-17 2010-10-21 Alfred Liang Pharmaceutical compositions
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2615137A1 (en) * 2007-12-17 2009-06-17 Pharmascience Inc. Single layered controlled release therapeutic system
CA2711475A1 (en) * 2008-01-10 2009-07-16 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release
BRPI0822026B8 (pt) * 2008-01-10 2021-05-25 Evonik Roehm Gmbh preparação farmacêutica ou nutracêutica, comprimido, gelatina ou cápsula de hpmc, e uso de uma ou uma mistura de uma pluralidade de polímeros ou copolímeros
ES2715274T3 (es) 2008-01-10 2019-06-03 Evonik Roehm Gmbh Preparación farmacéutica o nutracéutica recubierta con liberación de sustancias activas mejorada
US20100069390A1 (en) 2008-09-05 2010-03-18 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (ADHD)
US20100159009A1 (en) * 2008-12-24 2010-06-24 Zhongshui Yu Controlled-release formulations
US20100172979A1 (en) * 2008-12-24 2010-07-08 Zhongshui Yu Controlled-release formulations
WO2010096732A1 (en) * 2009-02-20 2010-08-26 University Of Medicine And Dentistry Of New Jersey Combination therapy to improve drug efficiency
KR101317592B1 (ko) 2009-10-28 2013-10-15 씨제이제일제당 (주) 프레가발린, 폴리에틸렌옥사이드 및 폴리비닐알코올-폴리에틸렌글리콜 그라프트 공중합체를 함유하는 위체류형 서방성 제제
KR101137467B1 (ko) * 2009-11-02 2012-04-20 안국약품 주식회사 테오브로민 함유 서방성 정제
WO2011107855A2 (en) * 2010-03-04 2011-09-09 Torrent Pharmaceuticals Limited Sustained release oral liquid suspension dosage form
KR101220830B1 (ko) * 2010-08-18 2013-01-10 안국약품 주식회사 테오브로민의 서방성 과립제 및 그 제조방법
EP2605664A1 (en) * 2010-08-18 2013-06-26 Kraft Foods Global Brands LLC Mouth-moistening gum compositions and products containing the same
RU2013136350A (ru) 2011-02-02 2015-03-27 АЛФАРМА ФАРМАСЬЮТИКЭЛЗ, ЭлЭлСи Фармацевтическая композиция, содержащая опиоидный агонист и секвестрированный антагонист
EP4233915A3 (en) * 2012-02-08 2023-09-20 Supernus Pharmaceuticals, Inc. Modified release formulations of viloxazine
US8859005B2 (en) 2012-12-03 2014-10-14 Intercontinental Great Brands Llc Enteric delivery of functional ingredients suitable for hot comestible applications
KR101659983B1 (ko) 2012-12-31 2016-09-26 주식회사 삼양바이오팜 용융 압출된 방출 제어용 약학 조성물, 및 이를 포함하는 경구용 제제
KR102241487B1 (ko) 2013-02-20 2021-04-16 주식회사 종근당 제어방출 펠릿으로 된 약제학적 조성물
CN110913841A (zh) * 2017-07-07 2020-03-24 帝斯曼知识产权资产管理有限公司 压制片剂
ES2938609T3 (es) 2017-09-20 2023-04-13 Tillotts Pharma Ag Preparación de formas farmacéuticas sólidas que comprenden anticuerpos mediante estratificación de solución/suspensión
US12569481B2 (en) 2020-06-12 2026-03-10 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
CN120981225A (zh) 2023-03-28 2025-11-18 蒂洛特斯制药股份有限公司 用于在下部胃肠道中缓释的包含抗体的固体口服剂型
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122070B1 (en) * 1983-03-18 1990-10-03 Matsushita Electric Industrial Co., Ltd. Video signal processing apparatus for video tape recorders
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
WO1992020326A1 (en) * 1991-05-20 1992-11-26 Marion Laboratories, Inc. Multi-layered controlled release formulation
JPH04360826A (ja) * 1991-06-07 1992-12-14 Bayer Yakuhin Kk 放出制御製剤
US5260068A (en) * 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
DE10149674A1 (de) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
DE10250543A1 (de) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Mehrschichtige Arzneiform

Also Published As

Publication number Publication date
US20070042045A1 (en) 2007-02-22
IL175562A0 (en) 2008-04-13
CN1863516A (zh) 2006-11-15
DE10353196A1 (de) 2005-06-16
KR20060113728A (ko) 2006-11-02
CA2544487A1 (en) 2005-05-26
JP2007510677A (ja) 2007-04-26
WO2005046561A2 (de) 2005-05-26
EP1682094A2 (de) 2006-07-26
WO2005046561A3 (de) 2006-03-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.