BRPI0416593A - moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmas - Google Patents
moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmasInfo
- Publication number
- BRPI0416593A BRPI0416593A BRPI0416593-4A BRPI0416593A BRPI0416593A BR PI0416593 A BRPI0416593 A BR PI0416593A BR PI0416593 A BRPI0416593 A BR PI0416593A BR PI0416593 A BRPI0416593 A BR PI0416593A
- Authority
- BR
- Brazil
- Prior art keywords
- sulfonyl
- peroxic
- derivative
- applications
- represent
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 230000000078 anti-malarial effect Effects 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 150000003456 sulfonamides Chemical class 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- -1 cyclic peroxide Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 230000000153 supplemental effect Effects 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"MOLéCULAS DUAIS CONTENDO UM DERIVADO PEROXìDICO, SìNTESE E APLICAçõES DAS MESMAS". A presente invenção refere-se às moléculas duais, correspondentes à fórmula (I), na qual - A representa um resíduo de molécula com atividade antipalúdica e/ou um resíduo que facilita a biodisponibilidade, - p, p<39>, p<39><39> representam independentemente uns dos outros 0 ou 1, pelo menos um de p ou de p<39><39>sendo igual a 1, - Y~ 1~ e Y~ 2~, idênticos ou diferentes, representam uma cadeia alquileno, comportando eventualmente um ou vários radicais amina, amida, tioamida, sulfonila, sulfonato, sulfonamida, carbonila, tiocarbonila, carboxila, tiocarboxila, éter ou tioéter, - U representa um radical amina, amida, tioamida, sulfonila, sulfonato, sulfonamida, carbonila, tiocarbonila, carboxila, tiocarboxila, éter ou tioéter, - Z~ 1~ e Z~ 2~ representam um radical alquileno ou o conjunto Z~ 1~ + Z~ 2~ representa uma estrutura policíclica, - R~ x~ e R~ y~ formam juntos um peróxido cíclico, compreendendo de 4 a 8 cadeias e comportando 1 ou 2 átomos de oxigênio suplementares na estrutura cíclica. Processo de preparo e aplicação como medicamentos com atividade antipalúdica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313371A FR2862304A1 (fr) | 2003-11-14 | 2003-11-14 | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| PCT/FR2004/002874 WO2005049619A1 (fr) | 2003-11-14 | 2004-11-09 | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416593A true BRPI0416593A (pt) | 2007-01-30 |
Family
ID=34508480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416593-4A BRPI0416593A (pt) | 2003-11-14 | 2004-11-09 | moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmas |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7947701B2 (pt) |
| EP (1) | EP1687312B1 (pt) |
| JP (1) | JP2007511489A (pt) |
| CN (1) | CN100448878C (pt) |
| AP (1) | AP2006003626A0 (pt) |
| AR (1) | AR046449A1 (pt) |
| AT (1) | ATE473983T1 (pt) |
| AU (1) | AU2004291374A1 (pt) |
| BR (1) | BRPI0416593A (pt) |
| CA (1) | CA2545491A1 (pt) |
| DE (1) | DE602004028149D1 (pt) |
| DK (1) | DK1687312T3 (pt) |
| ES (1) | ES2348624T3 (pt) |
| FR (1) | FR2862304A1 (pt) |
| HR (1) | HRP20100557T1 (pt) |
| IL (1) | IL175589A0 (pt) |
| MX (1) | MXPA06005409A (pt) |
| NO (1) | NO20062740L (pt) |
| NZ (1) | NZ547805A (pt) |
| PL (1) | PL1687312T3 (pt) |
| PT (1) | PT1687312E (pt) |
| SI (1) | SI1687312T1 (pt) |
| TW (1) | TW200530249A (pt) |
| WO (1) | WO2005049619A1 (pt) |
| ZA (1) | ZA200604247B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| WO2015085229A1 (en) * | 2013-12-08 | 2015-06-11 | Van Andel Research Institute | Autophagy inhibitors |
| WO2015123595A1 (en) * | 2014-02-14 | 2015-08-20 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2807433B1 (fr) * | 2000-04-06 | 2002-09-20 | Centre Nat Rech Scient | Molecules duales contenant un derives peroxydique, leur synthese et leurs applications therapeutiques |
| US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
-
2003
- 2003-11-14 FR FR0313371A patent/FR2862304A1/fr not_active Withdrawn
-
2004
- 2004-11-09 JP JP2006538893A patent/JP2007511489A/ja active Pending
- 2004-11-09 CN CNB2004800372615A patent/CN100448878C/zh not_active Expired - Fee Related
- 2004-11-09 DK DK04805417.5T patent/DK1687312T3/da active
- 2004-11-09 NZ NZ547805A patent/NZ547805A/en unknown
- 2004-11-09 BR BRPI0416593-4A patent/BRPI0416593A/pt not_active IP Right Cessation
- 2004-11-09 MX MXPA06005409A patent/MXPA06005409A/es not_active Application Discontinuation
- 2004-11-09 AP AP2006003626A patent/AP2006003626A0/xx unknown
- 2004-11-09 PL PL04805417T patent/PL1687312T3/pl unknown
- 2004-11-09 ES ES04805417T patent/ES2348624T3/es not_active Expired - Lifetime
- 2004-11-09 PT PT04805417T patent/PT1687312E/pt unknown
- 2004-11-09 ZA ZA200604247A patent/ZA200604247B/en unknown
- 2004-11-09 CA CA002545491A patent/CA2545491A1/fr not_active Abandoned
- 2004-11-09 SI SI200431519T patent/SI1687312T1/sl unknown
- 2004-11-09 DE DE602004028149T patent/DE602004028149D1/de not_active Expired - Lifetime
- 2004-11-09 WO PCT/FR2004/002874 patent/WO2005049619A1/fr not_active Ceased
- 2004-11-09 HR HR20100557T patent/HRP20100557T1/hr unknown
- 2004-11-09 EP EP04805417A patent/EP1687312B1/fr not_active Expired - Lifetime
- 2004-11-09 AT AT04805417T patent/ATE473983T1/de active
- 2004-11-09 AU AU2004291374A patent/AU2004291374A1/en not_active Abandoned
- 2004-11-12 AR ARP040104170A patent/AR046449A1/es unknown
- 2004-11-12 TW TW093134762A patent/TW200530249A/zh unknown
-
2006
- 2006-05-11 IL IL175589A patent/IL175589A0/en unknown
- 2006-05-12 US US11/433,890 patent/US7947701B2/en not_active Expired - Fee Related
- 2006-06-13 NO NO20062740A patent/NO20062740L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007511489A (ja) | 2007-05-10 |
| ZA200604247B (en) | 2008-05-28 |
| CA2545491A1 (fr) | 2005-06-02 |
| MXPA06005409A (es) | 2007-11-22 |
| EP1687312B1 (fr) | 2010-07-14 |
| IL175589A0 (en) | 2006-09-05 |
| AR046449A1 (es) | 2005-12-07 |
| PT1687312E (pt) | 2010-10-18 |
| CN1910189A (zh) | 2007-02-07 |
| DK1687312T3 (da) | 2010-11-08 |
| FR2862304A1 (fr) | 2005-05-20 |
| AP2006003626A0 (en) | 2006-06-30 |
| TW200530249A (en) | 2005-09-16 |
| DE602004028149D1 (de) | 2010-08-26 |
| NO20062740L (no) | 2006-08-11 |
| AU2004291374A1 (en) | 2005-06-02 |
| HRP20100557T1 (hr) | 2011-03-31 |
| ATE473983T1 (de) | 2010-07-15 |
| NZ547805A (en) | 2010-05-28 |
| PL1687312T3 (pl) | 2011-07-29 |
| CN100448878C (zh) | 2009-01-07 |
| ES2348624T3 (es) | 2010-12-09 |
| SI1687312T1 (sl) | 2010-11-30 |
| EP1687312A1 (fr) | 2006-08-09 |
| US7947701B2 (en) | 2011-05-24 |
| WO2005049619A1 (fr) | 2005-06-02 |
| US20070021423A1 (en) | 2007-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9911329A (pt) | Novos pseudodipeptìdeos de acila, processo de preparação e composições farmacêuticas contendo os mesmos | |
| KR960034164A (ko) | 스틸벤 유도체 및 이를 함유하는 약제학적 조성물 | |
| BR0114223A (pt) | Derivados de sulfonamida, farmaceuticamente ativos, possuindo grupos lipofìlicos e ionizáveis como inibidores de junkinases de proteìnas, uso de um derivado de sulfonamida, composição farmacêutica, contendo pelo menos um derivado de sulfonamida, processo para a preparação de um derivado de sulfonamida e compostos de sulfonamida | |
| BR0012880A (pt) | Derivados de mutilina e seu uso como antibacterianos | |
| BR0009641A (pt) | Derivados de 1,4-benzotiazepin-1,1-dióxido, substituìdos com radicais de açúcar, processo para produção dos mesmos, medicamentos contendo esses compostos e sua utilização | |
| ATE152113T1 (de) | Vanadium komplexe, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten | |
| BR9914036A (pt) | Agentes antiincrustação | |
| ATE368066T1 (de) | Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff | |
| AR063555A1 (es) | Derivados de androstano, su uso en la fabricacion de medicamentos, composiciones farmaceuticas que los comprenden y procesos para prepararlos | |
| BRPI0416593A (pt) | moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmas | |
| YU13396A (sh) | N-(3-benzofuranil) urea derivati, postupci za njihovo dobijanje, kompozicije koje ih sadrže i njihova upotreba u lekovima | |
| EA200601512A1 (ru) | Новые азабициклические соединения, способ их получения и фармацевтические композиции, которые их содержат | |
| BRPI0415020A (pt) | dissulfeto, sulfeto, sulfóxido e derivados de sulfona de açúcares cìclicos e usos dos mesmos | |
| ES2115904T3 (es) | Derivados amino ramificados del tiazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. | |
| BR9909386A (pt) | Piperidinas substituìdas, processo para sua preparação e seu uso como pesticidas e fungicidas | |
| CY1108071T1 (el) | Διμερη μορια που περιεχουν παραγωγο υπεροξειδιου, συνθεση και θεραπευτικες εφαρμογες αυτων | |
| BR9809643A (pt) | Compostos heterocìclicos, seu processo de preparo e as composições farmacêuticas que os contêm | |
| BR0003021A (pt) | Processo para a preparação de um composto de trifluoroacetato. | |
| BRPI0411068B8 (pt) | análogos de colchicosídeos | |
| ATE88479T1 (de) | Syntheseprodukte aus schwefel oder nichtschwefelhaltigen aminosaeuren mit pregnanderivaten, ihre herstellung und ihre anwendung. | |
| BR9803702A (pt) | Processo para preparação de produtos de politriazina contendo grupos 2,2,6,6-tetrametil-4-piperidila. | |
| UY29999A1 (es) | "n-pirazinil-fenilsulfonamidas, procedimientos y compuestos intemedios utilizados en su preparacion, composiciones farmaceuticas que las contienen y aplicaciones" | |
| MA28326A1 (fr) | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| BR9714007A (pt) | Novos derivados da eritromicina seu processo de preparação e sua aplicação como medicamentos | |
| TH74287A (th) | โมเลกุลคู่ซึ่งมีอนุพันธ์ของเปอร์ออกไซด์, การสังเคราะห์ และการใช้ทางการรักษาของสารเหล่านั้น |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 8A E 9A ANUIDADES. |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A, 10A, 11A, 12A, 13A, 14A E 15A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |