BRPI0416873A - derivados de benzoxazina e usos dos mesmos - Google Patents

derivados de benzoxazina e usos dos mesmos

Info

Publication number
BRPI0416873A
BRPI0416873A BRPI0416873-9A BRPI0416873A BRPI0416873A BR PI0416873 A BRPI0416873 A BR PI0416873A BR PI0416873 A BRPI0416873 A BR PI0416873A BR PI0416873 A BRPI0416873 A BR PI0416873A
Authority
BR
Brazil
Prior art keywords
compounds
benzoxazine derivatives
formula
benzoxazine
derivatives
Prior art date
Application number
BRPI0416873-9A
Other languages
English (en)
Inventor
Jacob Berger
Robin Douglas Clark
Shu-Hai Zhao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0416873A publication Critical patent/BRPI0416873A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE BENZOXAZINA E USOS DOS MESMOS". A presente invenção proporciona compostos de fórmula (I): ou sais farmaceuticamente aceitáveis, solvatos ou pró-drogas dos compostos, onde R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬,R¬ 5¬, R¬ 6¬, R¬ 7¬, R¬ 8¬,R¬ 9¬, X, Y e m são como definidos neste relatório. Também proporcionado são composições contendo esses compostos, o uso desses compostos para a produção de medicamentos, bem como métodos para preparar o composto de fórmula (I).
BRPI0416873-9A 2003-12-09 2004-11-30 derivados de benzoxazina e usos dos mesmos BRPI0416873A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52837803P 2003-12-09 2003-12-09
PCT/EP2004/013557 WO2005058847A1 (en) 2003-12-09 2004-11-30 Benzoxazine derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0416873A true BRPI0416873A (pt) 2007-02-27

Family

ID=34699863

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416873-9A BRPI0416873A (pt) 2003-12-09 2004-11-30 derivados de benzoxazina e usos dos mesmos

Country Status (21)

Country Link
US (1) US7202241B2 (pt)
EP (1) EP1694656B1 (pt)
JP (1) JP4527730B2 (pt)
KR (1) KR100827915B1 (pt)
CN (1) CN100532369C (pt)
AR (1) AR046753A1 (pt)
AT (1) ATE371653T1 (pt)
AU (1) AU2004299201B2 (pt)
BR (1) BRPI0416873A (pt)
CA (1) CA2547764A1 (pt)
CO (1) CO5700768A2 (pt)
DE (1) DE602004008668T2 (pt)
ES (1) ES2291984T3 (pt)
IL (1) IL175817A0 (pt)
MY (1) MY145576A (pt)
NO (1) NO20062491L (pt)
NZ (1) NZ547120A (pt)
RU (1) RU2354651C2 (pt)
TW (1) TW200522953A (pt)
WO (1) WO2005058847A1 (pt)
ZA (1) ZA200604725B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
ES2348467T3 (es) * 2004-09-30 2010-12-07 F. Hoffmann-La Roche Ag Derivados y usos de la benzoxazina y la quinoxalina.
EP1999121A1 (en) * 2006-03-17 2008-12-10 AstraZeneca AB Novel tetralins as 5-ht6 modulators
CL2007003044A1 (es) * 2006-10-24 2008-07-04 Wyeth Corp Compuestos derivados de benzoxazina; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y abuso o dependencia de sustancias entre otros.
WO2011023753A1 (en) * 2009-08-27 2011-03-03 Glaxo Group Limited Benzoxazine derivatives as glycine transport inhibitors
CN101836993B (zh) 2010-05-20 2011-06-22 山东大学 2，3-二氢-3-羟甲基-6-氨基-[1，4]-苯并噁嗪在制备诱导胚胎干细胞向血管内皮细胞分化药物中的应用
CN102060810B (zh) * 2010-12-20 2012-07-04 金坛市爱特生物科技有限公司 一种n-叔丁氧羰基-哌嗪的提纯方法
AU2015222917A1 (en) 2014-02-27 2016-09-15 Lycera Corporation Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods
JP6728061B2 (ja) 2014-05-05 2020-07-22 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療
JP6523337B2 (ja) 2014-05-05 2019-05-29 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
EP3166924B1 (en) 2014-07-08 2019-02-20 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
AU2016257997A1 (en) 2015-05-05 2017-11-09 Lycera Corporation Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
US10611740B2 (en) 2015-06-11 2020-04-07 Lycera Corporation Aryl dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
CN109568321B (zh) * 2019-01-14 2022-02-22 山东轩竹医药科技有限公司 RORγ调节剂
EP4192957A4 (en) * 2020-08-07 2024-09-04 Casma Therapeutics, Inc. Trpml modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803419D0 (en) * 1988-02-15 1988-03-16 Erba Carlo Spa 1 4-benzoxazine & 1 4-benzothiazine derivatives & process for their preparation
GB9507203D0 (en) 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
IL132409A0 (en) 1997-04-18 2001-03-19 Smithkline Beecham Plc Indole derivatives having combined 5ht1a 5ht1b and 5ht1d receptor antagonist activity
JP2002543194A (ja) * 1999-04-28 2002-12-17 ドクター・レディーズ・ラボラトリーズ・リミテッド 置換二環系ヘテロ環化合物、その製造方法、並びに抗肥満症及び抗高コレステロール血症剤としてのこれらの使用
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
EP1255743A1 (en) 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
DE60303376T2 (de) * 2002-05-13 2006-11-16 F. Hoffmann-La Roche Ag Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen
EP1562918B1 (en) * 2002-11-08 2008-01-16 F. Hoffmann-La Roche Ag Substituted benzoxazinones and uses thereof

Also Published As

Publication number Publication date
JP4527730B2 (ja) 2010-08-18
US20050124613A1 (en) 2005-06-09
ZA200604725B (en) 2007-12-27
MY145576A (en) 2012-02-29
AR046753A1 (es) 2005-12-21
NZ547120A (en) 2009-02-28
IL175817A0 (en) 2006-10-05
RU2006124513A (ru) 2008-01-27
KR20060097758A (ko) 2006-09-15
RU2354651C2 (ru) 2009-05-10
TW200522953A (en) 2005-07-16
AU2004299201B2 (en) 2009-12-03
US7202241B2 (en) 2007-04-10
KR100827915B1 (ko) 2008-05-07
EP1694656B1 (en) 2007-08-29
AU2004299201A1 (en) 2005-06-30
DE602004008668T2 (de) 2008-06-12
EP1694656A1 (en) 2006-08-30
DE602004008668D1 (de) 2007-10-11
JP2007513904A (ja) 2007-05-31
ATE371653T1 (de) 2007-09-15
CN100532369C (zh) 2009-08-26
NO20062491L (no) 2006-09-06
CA2547764A1 (en) 2005-06-30
WO2005058847A1 (en) 2005-06-30
CN1890227A (zh) 2007-01-03
CO5700768A2 (es) 2006-11-30
ES2291984T3 (es) 2008-03-01

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]