BRPI0416994A - inibidores de proteìna cinase com base em indolinona avançada - Google Patents

inibidores de proteìna cinase com base em indolinona avançada

Info

Publication number
BRPI0416994A
BRPI0416994A BRPI0416994-8A BRPI0416994A BRPI0416994A BR PI0416994 A BRPI0416994 A BR PI0416994A BR PI0416994 A BRPI0416994 A BR PI0416994A BR PI0416994 A BRPI0416994 A BR PI0416994A
Authority
BR
Brazil
Prior art keywords
protein kinase
indolinone
kinase inhibitors
advanced
based protein
Prior art date
Application number
BRPI0416994-8A
Other languages
English (en)
Inventor
Congxin Liang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of BRPI0416994A publication Critical patent/BRPI0416994A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"INIBIDORES DE PROTEìNA CINASE COM BASE EM INDOLINONA AVANçADA". Os derivados de pirrolil-indolinona de carbóxi de hidróxi têm propriedades de droga realçadas e inesperadas como inibidores de proteína cinases e são úteis no tratamento de distúrbios relacionados com atividades de proteína cinase anormais, tais como câncer.
BRPI0416994-8A 2003-11-26 2004-11-26 inibidores de proteìna cinase com base em indolinona avançada BRPI0416994A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52543003P 2003-11-26 2003-11-26
US54572104P 2004-02-18 2004-02-18
PCT/US2004/039728 WO2005053614A2 (en) 2003-11-26 2004-11-26 Advanced indolinone based protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0416994A true BRPI0416994A (pt) 2007-02-06

Family

ID=34657179

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416994-8A BRPI0416994A (pt) 2003-11-26 2004-11-26 inibidores de proteìna cinase com base em indolinona avançada

Country Status (9)

Country Link
US (1) US20080044881A1 (pt)
EP (1) EP1686987A4 (pt)
JP (1) JP2007512353A (pt)
AU (1) AU2004294981A1 (pt)
BR (1) BRPI0416994A (pt)
CA (1) CA2547066A1 (pt)
IL (1) IL175889A0 (pt)
MX (2) MXPA06006049A (pt)
WO (2) WO2005053686A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2610067A1 (en) * 2005-05-26 2006-11-30 The Scripps Research Institute Enhanced indolinone based protein kinase inhibitors
BRPI0616378A2 (pt) * 2005-09-22 2011-06-21 Scripps Research Inst inibidores de proteìna cinase baseados em alcóxi indolinona e métodos para modulação da atividade catalìtica
JP2009522276A (ja) * 2005-12-29 2009-06-11 ザ スクリップス リサーチ インスティテュート インドリノンベースのプロテインキナーゼ阻害剤のアミノ酸誘導体
CN101054379A (zh) * 2006-04-11 2007-10-17 上海恒瑞医药有限公司 吡咯取代的嘧啶酮衍生物、其制备方法及其在医药上的用途
CA2663147A1 (en) * 2006-09-11 2008-03-20 Curis, Inc. Substituted 2-indolinone as ptk inhibitors containing a zinc binding moiety
KR101507375B1 (ko) 2006-09-15 2015-04-07 엑스커버리 홀딩 컴퍼니 엘엘씨 키나아제 억제제 화합물
ES2383084T3 (es) 2006-12-04 2012-06-18 Jiangsu Simcere Pharmaceutical R&D Co., Ltd. Derivados de 3-pirrolo[b]ciclohexilen-2-dihidroindolinona y usos de los mismos
WO2010011834A2 (en) 2008-07-24 2010-01-28 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
CN102115472B (zh) * 2010-01-04 2013-12-04 深圳市天和医药科技开发有限公司 3-(2-吡咯亚甲基)氮杂吲哚啉-2-酮衍生物及其制法与应用
CN110016052B (zh) * 2018-01-08 2021-09-28 四川海思科制药有限公司 N-去乙基舒尼替尼的磷酰胺衍生物及其制备方法
CN109293638B (zh) * 2018-03-27 2020-08-14 大连理工大学 一种增强型的靶向识别受体酪氨酸激酶的荧光传感器及细胞膜荧光成像的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1255752T1 (sl) * 2000-02-15 2007-12-31 Pharmacia & Upjohn Co Llc S pirolom substituirani zaviralci 2-indolinon protein kinaza
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
US6797725B2 (en) * 2001-04-09 2004-09-28 Sugen, Inc. Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2007509173A (ja) * 2003-10-24 2007-04-12 シエーリング アクチエンゲゼルシャフト インドリノン誘導体類及び疾病状態、例えば癌の処理へのそれらの使用

Also Published As

Publication number Publication date
EP1686987A2 (en) 2006-08-09
IL175889A0 (en) 2006-10-05
AU2004294981A1 (en) 2005-06-16
US20080044881A1 (en) 2008-02-21
EP1686987A4 (en) 2009-02-25
WO2005053686A1 (en) 2005-06-16
WO2005053614A3 (en) 2006-02-23
JP2007512353A (ja) 2007-05-17
CA2547066A1 (en) 2005-06-16
MXPA06006049A (es) 2007-05-24
MXPA06006050A (es) 2007-05-24
WO2005053614A2 (en) 2005-06-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.