BRPI0417209A - formulações tópicas compreendendo um derivado de 1-n-arilpirazol e uma formamidina - Google Patents
formulações tópicas compreendendo um derivado de 1-n-arilpirazol e uma formamidinaInfo
- Publication number
- BRPI0417209A BRPI0417209A BRPI0417209-4A BRPI0417209A BRPI0417209A BR PI0417209 A BRPI0417209 A BR PI0417209A BR PI0417209 A BRPI0417209 A BR PI0417209A BR PI0417209 A BRPI0417209 A BR PI0417209A
- Authority
- BR
- Brazil
- Prior art keywords
- formulations
- formamidine
- derivative
- ticks
- provides
- Prior art date
Links
- PNKUSGQVOMIXLU-UHFFFAOYSA-N Formamidine Chemical compound NC=N PNKUSGQVOMIXLU-UHFFFAOYSA-N 0.000 title abstract 3
- 239000012049 topical pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 5
- 238000009472 formulation Methods 0.000 abstract 4
- 241000238876 Acari Species 0.000 abstract 3
- 241000255925 Diptera Species 0.000 abstract 2
- 244000045947 parasite Species 0.000 abstract 2
- RFEJUZJILGIRHQ-XRIOVQLTSA-N 2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)C(O)C(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-XRIOVQLTSA-N 0.000 abstract 1
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical class C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 abstract 1
- 239000005660 Abamectin Substances 0.000 abstract 1
- 206010063409 Acarodermatitis Diseases 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 abstract 1
- 206010061217 Infestation Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241001674048 Phthiraptera Species 0.000 abstract 1
- 241000447727 Scabies Species 0.000 abstract 1
- 241000258242 Siphonaptera Species 0.000 abstract 1
- 208000035056 Tick-Borne disease Diseases 0.000 abstract 1
- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 abstract 1
- 229960002587 amitraz Drugs 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 229940124339 anthelmintic agent Drugs 0.000 abstract 1
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 244000078703 ectoparasite Species 0.000 abstract 1
- 239000013057 ectoparasiticide Substances 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Chemical class COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 abstract 1
- 239000002728 pyrethroid Substances 0.000 abstract 1
- 208000005687 scabies Diseases 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 208000016523 tick-borne infectious disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"FORMULAçõES TóPICAS COMPREENDENDO UM DERIVADO DE 1-N-ARILPIRAZOL E UMA FORMAMIDINA". A presente invenção apresenta, entre outras coisas, novas formulações tópica compreendendo pelo menos um derivado de 1-N-arilpirazol e uma formamidina, como amitraz, e métodos para o tratamento, controle ou prevenção de infestações por parasitas em mamíferos ou aves. As formulações da invenção incluem formulações para aplicação no local, espalhamento ou pulverização e podem incluir um ectoparasiticida adicional, como um composto de IGR, um derivado de avermectina ou milbemicina, ou um inseticida piretróide, e/ou anti-helmínticos, como benzimidazóis ou imidazotiazóis. A formulação da invenção proporciona uma duração mais longa de controle de parasitas, a uma taxa mais rápida de controle. A fórmula da invenção continua eficaz durante até três meses após a primeira aplicação. Além disso, as formulações da invenção previnem a fixação de carrapatos ao animal, conferindo, dessa forma, proteção contra doenças transmitidas por carrapatos. Os ectoparasitas que podem ser controlados, tratados ou prevenidos pela presente invenção incluem carrapatos, pulgas, ácaros, sarna, piolhos, mosquitos, moscas e larvas de insetos no gado.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53052503P | 2003-12-17 | 2003-12-17 | |
| US60/530,525 | 2003-12-17 | ||
| US10/783,459 | 2004-02-20 | ||
| US10/783,459 US7531186B2 (en) | 2003-12-17 | 2004-02-20 | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| PCT/US2004/042379 WO2005058038A1 (en) | 2003-12-17 | 2004-12-17 | Topical formulations comprising a 1-n-arylpyrazole derivative and a formamidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0417209A true BRPI0417209A (pt) | 2007-02-06 |
| BRPI0417209B1 BRPI0417209B1 (pt) | 2018-06-26 |
Family
ID=34681575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417209-4A BRPI0417209B1 (pt) | 2003-12-17 | 2004-12-17 | Formulações tópicas compreendendo um derivado de 1-n-arilpirazol e uma formamidina |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7531186B2 (pt) |
| EP (1) | EP1694123B1 (pt) |
| JP (2) | JP4926719B2 (pt) |
| KR (1) | KR101187235B1 (pt) |
| CN (1) | CN1905794B (pt) |
| AP (1) | AP2083A (pt) |
| AU (2) | AU2004299120B2 (pt) |
| BR (1) | BRPI0417209B1 (pt) |
| CA (1) | CA2550256C (pt) |
| CO (1) | CO5700671A2 (pt) |
| CR (2) | CR8464A (pt) |
| ES (1) | ES2650713T3 (pt) |
| IL (1) | IL176360A (pt) |
| IN (1) | IN2012DN02432A (pt) |
| NO (1) | NO336284B1 (pt) |
| NZ (2) | NZ578628A (pt) |
| OA (1) | OA13346A (pt) |
| PL (2) | PL210628B1 (pt) |
| RU (1) | RU2361401C2 (pt) |
| WO (1) | WO2005058038A1 (pt) |
| ZA (1) | ZA200605109B (pt) |
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| CN1903029A (zh) * | 2005-07-27 | 2007-01-31 | 拜尔农作物科学有限公司 | 微乳剂 |
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| NZ552096A (en) * | 2006-12-15 | 2009-06-26 | Merial Ltd | Veterinary formulation |
| DE102006061537A1 (de) * | 2006-12-27 | 2008-07-03 | Bayer Healthcare Ag | Mittel zur Bekämpfung von Parasiten an Tieren |
| DE102006061538A1 (de) * | 2006-12-27 | 2008-07-03 | Bayer Healthcare Ag | Kombinationsprodukt zur Bekämpfung von Parasiten an Tieren |
| TW200846029A (en) * | 2007-02-09 | 2008-12-01 | Wyeth Corp | High dose, long-acting ectoparasiticide for extended control |
| US8097266B2 (en) * | 2007-11-26 | 2012-01-17 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| US8404260B2 (en) | 2008-04-02 | 2013-03-26 | Bayer Cropscience Lp | Synergistic pesticide compositions |
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| GB2464449B (en) * | 2008-09-05 | 2011-10-12 | Norbrook Lab Ltd | A topical ectoparasticide composition |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| US8450357B2 (en) * | 2008-11-19 | 2013-05-28 | Merial Limited | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
| US20130252911A1 (en) | 2009-11-02 | 2013-09-26 | Alpha-Biocare Gmbh | Compositions comprising flavonoid-containing extracts from plants of the genus citrus and/or isolated citrus flavonoids and specific cationic surface active agents, and said composition for use as an agent for treating infestations with head lice |
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| RU2437668C1 (ru) * | 2010-08-16 | 2011-12-27 | ГНУ Всероссийский научно-исследовательский институт ветеринарной энтомологии и арахнологии Россельхозакадемии (ГНУ ВНИИВЭА) | Способ лечения подкожнооводовых инвазий северных оленей и крупного рогатого скота |
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| RS61048B1 (sr) | 2011-09-12 | 2020-12-31 | Boehringer Ingelheim Animal Health Usa Inc | Paraziticidne kompozicije koje sadrže izoksazolin aktivni agens, postupak i njihove primene |
| KR102066757B1 (ko) | 2011-11-17 | 2020-01-15 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 아릴 피라졸 및 치환된 이미다졸을 함유하는 조성물, 그의 방법 및 용도 |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
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| US9314018B2 (en) | 2012-06-25 | 2016-04-19 | Institut de Recherche en Semiochimie et Ethologie Appliquee | Feline scratch marking semiochemicals |
| WO2014060960A1 (en) | 2012-10-16 | 2014-04-24 | Solano Smart Products Ltd. | Topical formulations for treating parasitic infestations |
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| US9049860B2 (en) | 2013-04-17 | 2015-06-09 | The Hartz Mountain Corporation | Ectoparasiticidal methods |
| US10064871B2 (en) | 2014-01-22 | 2018-09-04 | Biomimetix Jv, Llc | Methods of treating skin disorders |
| WO2015112586A1 (en) | 2014-01-22 | 2015-07-30 | Duke University | Methods of treating pruritus |
| RU2557986C1 (ru) * | 2014-07-31 | 2015-07-27 | Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт ветеринарной энтомологии и арахнологии" (ФГБНУ ВНИИВЭА) | Способ защиты крупного рогатого скота от иксодовых клещей |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| CN105248434A (zh) * | 2015-02-12 | 2016-01-20 | 四川利尔作物科学有限公司 | 杀虫杀螨组合物及其应用 |
| EP3228317A1 (en) * | 2016-04-07 | 2017-10-11 | Smartpak Equine LLC | Equine parasite treatment methods and compositions |
| US10512628B2 (en) | 2016-04-24 | 2019-12-24 | Solano S.P. Ltd. | Dinotefuran liquid flea and tick treatment |
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| KR20250057155A (ko) | 2017-12-15 | 2025-04-28 | 타르서스 파마수티칼스, 아이엔씨. | 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법 |
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| GR1002899B (el) * | 1996-03-29 | 1998-05-11 | Rhone Merieux | Περιλαιμιο κατα ψυλλων και κροτωνων για σκυλους και γατες, με βαση ν-φαινυλπυραζολη |
| IE80657B1 (en) | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
| US5885607A (en) | 1996-03-29 | 1999-03-23 | Rhone Merieux | N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs |
| FR2752525B1 (fr) | 1996-08-20 | 2000-05-05 | Rhone Merieux | Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede |
| US6413542B1 (en) | 1996-03-29 | 2002-07-02 | Merial | Direct pour-on antiparasitic skin solution and methods for treating, preventing and controlling myasis |
| US6010710A (en) | 1996-03-29 | 2000-01-04 | Merial | Direct pour-on skin solution for antiparasitic use in cattle and sheep |
| US6998131B2 (en) | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
| JP4126621B2 (ja) | 1996-11-25 | 2008-07-30 | 日本農薬株式会社 | 殺虫・殺ダニ剤 |
| WO1998039972A1 (en) | 1997-03-11 | 1998-09-17 | Rhone-Poulenc Agro | Pesticidal combination |
| JPH10324605A (ja) * | 1997-05-22 | 1998-12-08 | Nippon Nohyaku Co Ltd | 殺ダニ剤組成物及びその使用方法 |
| AUPP105597A0 (en) | 1997-12-19 | 1998-01-15 | Schering-Plough Animal Health Limited | Solvent/surfactant insecticidal pour-on formulation |
| US6090751A (en) | 1998-06-10 | 2000-07-18 | Rhone-Poulenc Agro | Emulsifiable concentrate comprising an insecticidal 1-arylpyrazole |
| CO5210925A1 (es) * | 1998-11-17 | 2002-10-30 | Novartis Ag | Derivados de diamino nitroguanidina tetrasustituidos |
| US6350922B1 (en) | 1998-12-18 | 2002-02-26 | The Dow Chemical Company | Process for making 2,3-dihalopropanols |
| BR0017616B1 (pt) * | 1999-03-12 | 2013-03-05 | composiÇço inseticida sinÉrgica, e, processos para controle de insetos, e para proteger plantas contra infestaÇço e ataque de insetos. | |
| US20020090381A1 (en) | 1999-04-09 | 2002-07-11 | H. Kim Bottomly | System for controlling immune system response to antigen |
| GB9916052D0 (en) | 1999-07-08 | 1999-09-08 | Pfizer Ltd | Anthelmintic compositions |
| CA2311881C (en) | 2000-06-16 | 2007-08-28 | Gary O. Maupin | Control of arthropods in rodents |
| CA2311862C (en) | 2000-06-16 | 2006-10-10 | Gary O. Maupin | Control of arthropod vectors of parasitic diseases |
| NZ505779A (en) | 2000-07-14 | 2003-06-30 | Akzo Nobel Nv | Pesticidal composition containing insect growth regulating (IGR) insecticide in an aromatic hydrocarbon and/or pyrrolidone and/or propylene glycol monoalkyl ether solvent system |
| AR036872A1 (es) * | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
| US7906128B2 (en) * | 2002-10-21 | 2011-03-15 | Wyeth Llc | Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals |
| US7262214B2 (en) * | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| US8450357B2 (en) * | 2008-11-19 | 2013-05-28 | Merial Limited | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
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