BRPI0417272B8 - processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato - Google Patents

processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato

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Publication number
BRPI0417272B8
BRPI0417272B8 BRPI0417272A BRPI0417272A BRPI0417272B8 BR PI0417272 B8 BRPI0417272 B8 BR PI0417272B8 BR PI0417272 A BRPI0417272 A BR PI0417272A BR PI0417272 A BRPI0417272 A BR PI0417272A BR PI0417272 B8 BRPI0417272 B8 BR PI0417272B8
Authority
BR
Brazil
Prior art keywords
amino
isobutyl
hydroxypropylcarbamate
hexahydrofuro
aminophenyl
Prior art date
Application number
BRPI0417272A
Other languages
English (en)
Inventor
M Ebert Birgit
Burghard Zinser Hartmut
Martha Felix Goyvaerts Nicolaas
Tom Bert Paul Wigerinck Piet
Original Assignee
Janssen R&D Ireland
Janssen Sciences Ireland Uc
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34740665&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0417272(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R&D Ireland, Janssen Sciences Ireland Uc, Tibotec Pharm Ltd filed Critical Janssen R&D Ireland
Publication of BRPI0417272A publication Critical patent/BRPI0417272A/pt
Publication of BRPI0417272B1 publication Critical patent/BRPI0417272B1/pt
Publication of BRPI0417272B8 publication Critical patent/BRPI0417272B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

processo para a preparação de (3r,3as,6ar)-hexahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4aminofenil) sulfonil] (isobutil) amino]-1-benzil-2hidroxipropilcarbamato. a presente invenção refere-se a um processo para a preparação de (3r,3as,6ar)hexahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato bem como intermediários para uso em ditos processos. mais em particular, a invenção relaciona-se a processos para a preparação de (3r,3as,6ar)hexahidrofuro [2,3b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino ]-1-benzil-2hidroxipropilcarbamato o qual faz uso do intermediário 4-amino-n[(2r,3s)-3amino-2-hidróxi-4-fenilbutil]-n-isobutil)benzeno sulfonamida, e os quais são processos amenáveis a escala industrial. (3r,3as,6ar)hexahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2hidroxipropilcarbamato é particularmente útil como inibidor de hiv-protease.
BRPI0417272A 2003-12-23 2004-12-23 processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato BRPI0417272B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP031049497 2003-12-23
EP03104949 2003-12-23
US56818304P 2004-05-04 2004-05-04
US60/568,183 2004-05-04
PCT/EP2004/053692 WO2005063770A1 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Publications (3)

Publication Number Publication Date
BRPI0417272A BRPI0417272A (pt) 2007-03-27
BRPI0417272B1 BRPI0417272B1 (pt) 2020-08-18
BRPI0417272B8 true BRPI0417272B8 (pt) 2021-05-25

Family

ID=34740665

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417272A BRPI0417272B8 (pt) 2003-12-23 2004-12-23 processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato

Country Status (21)

Country Link
EP (1) EP1725566B1 (pt)
KR (1) KR101192859B1 (pt)
CN (1) CN1898248B (pt)
AT (1) ATE433982T1 (pt)
AU (1) AU2004309122B2 (pt)
BR (1) BRPI0417272B8 (pt)
CA (1) CA2549460C (pt)
CY (1) CY1109379T1 (pt)
DE (1) DE602004021640D1 (pt)
DK (1) DK1725566T3 (pt)
ES (1) ES2328701T3 (pt)
HR (1) HRP20090488T1 (pt)
IL (1) IL174960A (pt)
MX (1) MXPA06007211A (pt)
NO (1) NO337636B1 (pt)
PL (1) PL1725566T3 (pt)
PT (1) PT1725566E (pt)
RU (1) RU2376308C2 (pt)
SI (1) SI1725566T1 (pt)
WO (1) WO2005063770A1 (pt)
ZA (1) ZA200605163B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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AR058238A1 (es) * 2005-11-28 2008-01-23 Tibotec Pharm Ltd Compuestos y derivados de aminofenilsulfonamida sustituida como inhibidores de proteasa del vih
ES2359949T3 (es) * 2006-11-09 2011-05-30 Tibotec Pharmaceuticals Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol.
BRPI0810609A2 (pt) * 2007-04-27 2014-10-21 Tibotec Pharm Ltd Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
AU2008317375B2 (en) * 2007-10-26 2013-02-28 Concert Pharmaceuticals, Inc. Deuterated darunavir
AR073248A1 (es) * 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2426124T3 (pl) * 2009-05-13 2013-12-31 Meiji Seika Pharma Co Ltd Sposób wytwarzania pirypiropenowych pochodnych
WO2011048604A2 (en) 2009-09-17 2011-04-28 Matrix Laboratories Limited An improved process for the preparation of darunavir
AU2010340799B2 (en) 2010-01-05 2015-06-11 Cipla Limited Darunavir polymorph and process for preparation thereof
EP2528923B1 (en) 2010-01-28 2014-07-30 Mapi Pharma Limited Process for the preparation of darunavir and darunavir intermediates
CN102584844B (zh) * 2011-01-11 2016-04-13 浙江九洲药业股份有限公司 一种达芦那韦晶型及其制备方法
ES2848216T3 (es) 2012-07-24 2021-08-05 Laurus Labs Ltd Un proceso para la preparación de Darunavir
CN103893178B (zh) * 2014-03-19 2016-06-01 中山大学 苯-磺酰胺类化合物在制备抗hiv-1病毒药物中的应用
US20160075643A1 (en) * 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
WO2016207907A1 (en) * 2015-06-25 2016-12-29 Msn Laboratories Private Limited Process for the preparation of [(1 s,2r)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1 -(phenylmethyl)propyl]-carbamic acid (3r,3as,6ar)hexahydro furo[2,3-b]furan-3-yl ester and its amorphous form
US10407438B2 (en) 2016-10-27 2019-09-10 Gilead Sciences, Inc. Crystalline forms of darunavir
US10774088B2 (en) * 2016-11-17 2020-09-15 Janssen Sciences Ireland Unlimited Company Simplified procedure for the preparation of darunavir
CN118026896A (zh) * 2020-12-30 2024-05-14 上海飞腾医药科技有限公司 抗hiv类药物中间体晶体的生长方法和所得晶体
CN113896658A (zh) * 2021-09-24 2022-01-07 上药康丽（常州）药业有限公司 一种利用微通道反应器合成地瑞那韦中间体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022287A1 (en) 1995-01-20 1996-07-25 G.D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
KR100411856B1 (ko) 1995-02-03 2004-05-20 카네카 코포레이션 α-할로케톤,α-할로히드린및에폭사이드의제조법
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
AU717598B2 (en) 1995-03-10 2000-03-30 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
GB9805898D0 (en) * 1998-03-20 1998-05-13 Glaxo Group Ltd Process for the sythesis of hiv protease inhibitors
EP1067125B1 (en) 1999-01-29 2006-07-26 Kaneka Corporation PROCESSES FOR THE PREPARATION OF threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTANE DERIVATIVES
RU2190614C2 (ru) * 2000-07-11 2002-10-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл" Способ получения 1,4,3,6-диангидро-д-сорбита динитрата
KR20020046948A (ko) 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
EE05307B1 (et) 2001-05-11 2010-06-15 Tibotec Pharmaceuticals Ltd. Laiaspektrilised 2-aminobensoksasoolsulfoonamiidid kui HIV proteaasi inhibiitorid, nende kasutamine, farmatseutiline kompositsioon ja meetod retroviiruse replikatsiooni inhibeerimiseks
EP1466896A4 (en) * 2001-12-28 2005-01-26 Ajinomoto Kk PROCESS FOR PRODUCING A CRYSTAL OF A BENZENESULFONAMIDE DERIVATIVE, AND A NEW CRYSTAL OF AN INTERMEDIATE PRODUCT OF SAID DERIVATIVE AND METHOD FOR PRODUCING THE SAME

Also Published As

Publication number Publication date
IL174960A0 (en) 2006-08-20
MXPA06007211A (es) 2006-08-18
RU2006126670A (ru) 2008-01-27
IL174960A (en) 2011-06-30
KR20060123740A (ko) 2006-12-04
KR101192859B1 (ko) 2012-10-19
CY1109379T1 (el) 2014-07-02
RU2376308C2 (ru) 2009-12-20
BRPI0417272B1 (pt) 2020-08-18
PT1725566E (pt) 2009-09-16
NO337636B1 (no) 2016-05-23
PL1725566T3 (pl) 2009-11-30
ES2328701T3 (es) 2009-11-17
CA2549460A1 (en) 2005-07-14
EP1725566A1 (en) 2006-11-29
DK1725566T3 (da) 2009-10-05
CN1898248A (zh) 2007-01-17
EP1725566B1 (en) 2009-06-17
AU2004309122A1 (en) 2005-07-14
CA2549460C (en) 2014-08-05
ZA200605163B (en) 2007-12-27
HRP20090488T1 (hr) 2009-10-31
CN1898248B (zh) 2011-08-17
SI1725566T1 (sl) 2009-12-31
BRPI0417272A (pt) 2007-03-27
AU2004309122B2 (en) 2011-07-21
ATE433982T1 (de) 2009-07-15
DE602004021640D1 (de) 2009-07-30
NO20063401L (no) 2006-07-21
WO2005063770A1 (en) 2005-07-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 493/04, A61P 31/00

Ipc: C07D 493/04 (2011.01)

B25D Requested change of name of applicant approved

Owner name: TIBOTEC PHARMACEUTICALS (IE)

B25D Requested change of name of applicant approved

Owner name: JANSSEN R AND D IRELAND (IE)

B25A Requested transfer of rights approved

Owner name: JANSSEN SCIENCES IRELAND UC (IE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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