BRPI0810609A2 - Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida - Google Patents

Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida

Info

Publication number
BRPI0810609A2
BRPI0810609A2 BRPI0810609-6A2A BRPI0810609A BRPI0810609A2 BR PI0810609 A2 BRPI0810609 A2 BR PI0810609A2 BR PI0810609 A BRPI0810609 A BR PI0810609A BR PI0810609 A2 BRPI0810609 A2 BR PI0810609A2
Authority
BR
Brazil
Prior art keywords
hydroxy
amino
derivatives
phenylbutil
nzenosulfonilamide
Prior art date
Application number
BRPI0810609-6A2A
Other languages
English (en)
Inventor
Hartmut Burghard Zinser
Peter Hermann Hoelzle
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of BRPI0810609A2 publication Critical patent/BRPI0810609A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0810609-6A2A 2007-04-27 2008-04-25 Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida BRPI0810609A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107177 2007-04-27
PCT/EP2008/055042 WO2008132154A1 (en) 2007-04-27 2008-04-25 Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives

Publications (1)

Publication Number Publication Date
BRPI0810609A2 true BRPI0810609A2 (pt) 2014-10-21

Family

ID=38924830

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810609-6A2A BRPI0810609A2 (pt) 2007-04-27 2008-04-25 Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida

Country Status (20)

Country Link
US (1) US8076513B2 (pt)
EP (1) EP2152667B1 (pt)
JP (1) JP2010525029A (pt)
CN (1) CN101668734A (pt)
AT (1) ATE498606T1 (pt)
AU (1) AU2008244306A1 (pt)
BR (1) BRPI0810609A2 (pt)
CA (1) CA2682616A1 (pt)
CY (1) CY1111457T1 (pt)
DE (1) DE602008005012D1 (pt)
DK (1) DK2152667T3 (pt)
ES (1) ES2360654T3 (pt)
HR (1) HRP20110290T1 (pt)
IL (1) IL200811A0 (pt)
MX (1) MX2009011574A (pt)
PL (1) PL2152667T3 (pt)
PT (1) PT2152667E (pt)
RU (1) RU2009143867A (pt)
SI (1) SI2152667T1 (pt)
WO (1) WO2008132154A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
CN102725295A (zh) 2010-01-28 2012-10-10 Mapi医药公司 制备达芦那韦和达芦那韦中间体的方法
WO2011158259A1 (en) * 2010-06-18 2011-12-22 Matrix Laboratories Ltd Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts thereof
WO2012070057A1 (en) 2010-11-23 2012-05-31 Matrix Laboratories Ltd Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol
CN105315178B (zh) * 2014-07-09 2018-07-06 浙江九洲药业股份有限公司 达芦那韦相关物质及其制备方法
CN117142989A (zh) * 2020-12-30 2023-12-01 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体a的生长方法和所得晶体

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
JPH07110846B2 (ja) * 1987-12-23 1995-11-29 アグロカネショウ株式会社 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤
DK0810209T3 (da) * 1992-08-25 2002-08-12 Monsanto Co Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
AU7669794A (en) 1993-08-24 1995-03-21 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US5929284A (en) 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
JP2000515488A (ja) 1995-11-15 2000-11-21 ジー．ディー．サール アンド カンパニー 置換スルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド レトロウイルスプロテアーゼ阻害剤
AU767728B2 (en) 1998-06-19 2003-11-20 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
ES2604662T3 (es) 1998-06-23 2017-03-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Ensayo de acondicionamiento físico y métodos para reducir la resistencia del VIH a la terapia
AU4828199A (en) 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
ATE269314T1 (de) 1998-08-25 2004-07-15 Kaneka Corp Verfahren zur herstellung von (2r, 3s)-amino-1,2- oxiran
EP1067125B1 (en) 1999-01-29 2006-07-26 Kaneka Corporation PROCESSES FOR THE PREPARATION OF threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTANE DERIVATIVES
ES2254156T3 (es) 1999-02-12 2006-06-16 Vertex Pharmaceuticals Incorporated Inhibidores de aspartil-proteasa.
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
WO2001046120A1 (en) 1999-12-23 2001-06-28 Aerojet Fine Chemicals Llc Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
JP2002332270A (ja) * 2001-03-07 2002-11-22 Ajinomoto Co Inc スルホンアミド誘導体の製造方法
JP4521185B2 (ja) 2001-09-10 2010-08-11 テイボテク・フアーマシユーチカルズ・リミテツド ヘキサヒドロ−フロ［２，３−ｂ］フラン−３−オールの製造法
AU2003287038A1 (en) 2002-10-09 2004-05-04 The Board Of Trustees Of The University Of Illinois METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO (2, 3-b) FURAN AND RELATED COMPOUNDS
AU2003275675A1 (en) 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
UA79404C2 (en) * 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
HRP20090488T1 (hr) * 2003-12-23 2009-10-31 Tibotec Pharmaceuticals Ltd. Postupak za pripravu (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-il(1s,23)-3-[[(4-aminofenil)sulfonil](izobutil)amino]-1-benzil-2-hidroksipropilkarbamata
TWI383975B (zh) 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
CY1111457T1 (el) 2015-08-05
CA2682616A1 (en) 2008-11-06
EP2152667A1 (en) 2010-02-17
US8076513B2 (en) 2011-12-13
JP2010525029A (ja) 2010-07-22
IL200811A0 (en) 2010-05-17
RU2009143867A (ru) 2011-06-10
EP2152667B1 (en) 2011-02-16
DE602008005012D1 (de) 2011-03-31
CN101668734A (zh) 2010-03-10
DK2152667T3 (da) 2011-05-16
PT2152667E (pt) 2011-04-06
PL2152667T3 (pl) 2011-06-30
ATE498606T1 (de) 2011-03-15
MX2009011574A (es) 2009-11-09
US20100121094A1 (en) 2010-05-13
HRP20110290T1 (hr) 2011-05-31
WO2008132154A1 (en) 2008-11-06
AU2008244306A1 (en) 2008-11-06
SI2152667T1 (sl) 2011-06-30
ES2360654T3 (es) 2011-06-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]