ECSP066615A - Derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina - Google Patents

Derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina

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Publication number
ECSP066615A
ECSP066615A EC2006006615A ECSP066615A ECSP066615A EC SP066615 A ECSP066615 A EC SP066615A EC 2006006615 A EC2006006615 A EC 2006006615A EC SP066615 A ECSP066615 A EC SP066615A EC SP066615 A ECSP066615 A EC SP066615A
Authority
EC
Ecuador
Prior art keywords
derivatives
present
cycalalkylaminopirrolidine
chemiokin
chemokine receptor
Prior art date
Application number
EC2006006615A
Other languages
English (en)
Inventor
Chu Biao Xue
Brian Metcalf
Darius J Robinson
Amy Qi Han
Changsheng Zheng
Anlai Wang
Yingxin Zhang
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP066615A publication Critical patent/ECSP066615A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

La presente invención está dirigida a moduladores de receptor de quimiocina, por ejemplo antagonistas, y a su uso como agentes medicinales. La presente invención se refiere adicionalmente a nuevos compuestos y procedimientos de tratamiento médico de la inflamación y otros trastornos, especialmente aquellos asociados a la acumulación de linfocitos o monocitos tales como artritis reumatoide, lupus, enfermedades de injerto contra huésped y/o rechazo de transplante. Más particularmente, la presente invención se refiere a derivados de 3-cicloalquilaminopirrolidina y a su uso como moduladores de receptores de quimiocina.
EC2006006615A 2003-12-18 2006-06-07 Derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina ECSP066615A (es)

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US53127003P 2003-12-18 2003-12-18

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ECSP066615A true ECSP066615A (es) 2006-10-25

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US (5) US7576089B2 (es)
EP (1) EP1696919B1 (es)
JP (1) JP4740151B2 (es)
KR (2) KR20080052683A (es)
CN (2) CN1893945A (es)
AP (1) AP2439A (es)
AU (1) AU2004305079B2 (es)
BR (1) BRPI0417605B8 (es)
CA (1) CA2550596C (es)
CR (1) CR8455A (es)
DK (1) DK1696919T3 (es)
EA (1) EA013631B1 (es)
EC (1) ECSP066615A (es)
ES (1) ES2439894T3 (es)
GE (1) GEP20084505B (es)
IL (1) IL175953A (es)
IS (1) IS2956B (es)
MA (1) MA28391B1 (es)
MX (1) MXPA06007000A (es)
NI (1) NI200600136A (es)
NO (1) NO336486B1 (es)
NZ (1) NZ547316A (es)
OA (1) OA13338A (es)
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UA (1) UA82917C2 (es)
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ZA (1) ZA200604875B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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