BRPI0417895A - derivado de indeno (2,1a)indeno e isoindolo(2,1-a)indole, processo para a preparação de um composto, composições farmacêuticas, uso do derivado, uso de um rádiocomposto identificado e método para um tratamento de prevenção ou um tratamento de desordem - Google Patents
derivado de indeno (2,1a)indeno e isoindolo(2,1-a)indole, processo para a preparação de um composto, composições farmacêuticas, uso do derivado, uso de um rádiocomposto identificado e método para um tratamento de prevenção ou um tratamento de desordemInfo
- Publication number
- BRPI0417895A BRPI0417895A BRPI0417895-5A BRPI0417895A BRPI0417895A BR PI0417895 A BRPI0417895 A BR PI0417895A BR PI0417895 A BRPI0417895 A BR PI0417895A BR PI0417895 A BRPI0417895 A BR PI0417895A
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- indene
- derivative
- treatment
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 title 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical compound C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 title 1
- 150000002469 indenes Chemical class 0.000 title 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 230000003449 preventive effect Effects 0.000 title 1
- JJUQRPHMJPHFBH-UHFFFAOYSA-N 6h-isoindolo[2,1-a]indole Chemical class C1=CC=C2N3CC4=CC=CC=C4C3=CC2=C1 JJUQRPHMJPHFBH-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- OZEPXROCWSMGGM-UHFFFAOYSA-N dibenzopentalene Chemical compound C1=CC=C2C=C3C4=CC=CC=C4C=C3C2=C1 OZEPXROCWSMGGM-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADO DE INDENO ¢2,1A! INDENO E ISOINDOLO ¢2,1-A! ìNDOLE, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, COMPOSIçõES FARMACêUTICAS, USO DO DERIVADO, USO DE UM RADIOCOMPOSTO IDENTIFICADO E MéTODO PARA UM TRATAMENTO DE PREVENçãO OU UM TRATAMENTO DE DESORDEM. A presente invenção descreve os derivados de indeno¢2,la!indeno e de isoindolo¢2,1-a! índole tendo a Fórmula (I), os seus sais e os seus estéreo isómeros, nos quais X, R~ 1~,R~ 2~, R~ 3~, R~ 4~, R~ 6~, R~ 7~, R~ 8~, R~ 9~, R~ 11~, R~ 12~ , R~ 13~ e R~ 1~ são conforme descritos no relatório descritivo. A invenção também proporciona um método para preparar um composto com a Fórmula (1), uma composição farmacêutica contendo tais compostos e um método para fabricar um medicamento. Estes compostos são úteis no tratamento de várias desordens do CNS, de desordens hematológicas, de desordens de alimentação, de doenças associadas com a dor, de doenças respiratórias, de desordens qenito-urológicas, de doenças cardiovasculares e de câncer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5CH2004 | 2004-01-02 | ||
| IN5/CHE/2004 | 2004-01-02 | ||
| PCT/IN2004/000430 WO2005066184A1 (en) | 2004-01-02 | 2004-12-30 | Novel indeno[2,1a]indenes and isoindol[2,1-a]indoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0417895A true BRPI0417895A (pt) | 2008-03-04 |
| BRPI0417895B1 BRPI0417895B1 (pt) | 2020-03-03 |
| BRPI0417895B8 BRPI0417895B8 (pt) | 2021-05-25 |
Family
ID=34746651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417895A BRPI0417895B8 (pt) | 2004-01-02 | 2004-12-30 | composto, processo para a preparação de um composto e uso do composto |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7388024B2 (pt) |
| EP (1) | EP1704154B1 (pt) |
| JP (1) | JP4886522B2 (pt) |
| KR (1) | KR101049868B1 (pt) |
| CN (1) | CN1918173B (pt) |
| AT (1) | ATE430752T1 (pt) |
| AU (1) | AU2004312229B2 (pt) |
| BR (1) | BRPI0417895B8 (pt) |
| CA (1) | CA2552106C (pt) |
| CY (1) | CY1109278T1 (pt) |
| DE (1) | DE602004021031D1 (pt) |
| DK (1) | DK1704154T3 (pt) |
| EA (1) | EA010406B1 (pt) |
| ES (1) | ES2326658T3 (pt) |
| HR (1) | HRP20090419T1 (pt) |
| MX (1) | MXPA06007415A (pt) |
| NO (1) | NO335838B1 (pt) |
| NZ (1) | NZ548743A (pt) |
| PL (1) | PL1704154T3 (pt) |
| PT (1) | PT1704154E (pt) |
| RS (1) | RS50824B (pt) |
| SI (1) | SI1704154T1 (pt) |
| WO (1) | WO2005066184A1 (pt) |
| ZA (1) | ZA200604748B (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2421870B1 (en) * | 2009-04-23 | 2016-03-09 | AbbVie Inc. | Modulators of 5-ht receptors and methods of use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
| EA200300717A1 (ru) * | 2000-12-22 | 2003-12-25 | Уайт | Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов |
| MXPA03006605A (es) * | 2001-01-30 | 2003-09-22 | Lilly Co Eli | Esteres de indol-5-ilo del acido bencensulfonico como antagonistas del receptor 5-ht6. |
| DK1438045T3 (da) * | 2001-10-23 | 2007-06-11 | Biovitrum Ab | Anvendelse af indol- og indolin-derivater ved behandling af obesitet eller til reduktion af födeindtag |
| ES2187300B1 (es) * | 2001-11-14 | 2004-06-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. |
| DK1455779T3 (da) * | 2001-12-20 | 2006-10-30 | Wyeth Corp | Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander |
| EP1472544A2 (en) | 2002-02-01 | 2004-11-03 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor |
| WO2003066056A1 (en) | 2002-02-05 | 2003-08-14 | Glaxo Group Limited | Method of promoting neuronal growth |
| BR0312175A (pt) * | 2002-06-21 | 2005-04-05 | Suven Life Sciences Ltd | Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso |
| ES2297216T3 (es) * | 2002-06-21 | 2008-05-01 | Suven Life Sciences Limited | Indoles tetraciclicos arilsulfonil que tienen afinidad con el receptor de la serotonina. |
| SI1517909T1 (sl) * | 2002-06-21 | 2007-06-30 | Suven Life Sciences Ltd | Novi tetraciklični arilkarbonil indoli, ki imajo afiniteto za serotoninski receptor, uporabni kot terapevtska sredstva, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo |
| US7507835B2 (en) | 2002-11-28 | 2009-03-24 | Suven Life Sciences Ltd. | N-arylsulfonyl-3-aminoalkoxyindoles |
| ATE401307T1 (de) | 2002-11-28 | 2008-08-15 | Suven Life Sciences Ltd | N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
| WO2004048331A1 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| JP4571507B2 (ja) | 2002-12-18 | 2010-10-27 | スベン ライフ サイエンシズ リミティド | セロトニン受容体親和性を有する四環系３−置換インドール |
-
2004
- 2004-12-30 AT AT04806777T patent/ATE430752T1/de active
- 2004-12-30 PL PL04806777T patent/PL1704154T3/pl unknown
- 2004-12-30 SI SI200431175T patent/SI1704154T1/sl unknown
- 2004-12-30 MX MXPA06007415A patent/MXPA06007415A/es active IP Right Grant
- 2004-12-30 DE DE602004021031T patent/DE602004021031D1/de not_active Expired - Lifetime
- 2004-12-30 EA EA200601270A patent/EA010406B1/ru not_active IP Right Cessation
- 2004-12-30 KR KR1020067012980A patent/KR101049868B1/ko not_active Expired - Fee Related
- 2004-12-30 DK DK04806777T patent/DK1704154T3/da active
- 2004-12-30 BR BRPI0417895A patent/BRPI0417895B8/pt not_active IP Right Cessation
- 2004-12-30 HR HR20090419T patent/HRP20090419T1/hr unknown
- 2004-12-30 CN CN2004800417654A patent/CN1918173B/zh not_active Expired - Fee Related
- 2004-12-30 JP JP2006546485A patent/JP4886522B2/ja not_active Expired - Fee Related
- 2004-12-30 WO PCT/IN2004/000430 patent/WO2005066184A1/en not_active Ceased
- 2004-12-30 ES ES04806777T patent/ES2326658T3/es not_active Expired - Lifetime
- 2004-12-30 EP EP04806777A patent/EP1704154B1/en not_active Expired - Lifetime
- 2004-12-30 CA CA2552106A patent/CA2552106C/en not_active Expired - Fee Related
- 2004-12-30 AU AU2004312229A patent/AU2004312229B2/en not_active Ceased
- 2004-12-30 NZ NZ548743A patent/NZ548743A/xx not_active IP Right Cessation
- 2004-12-30 PT PT04806777T patent/PT1704154E/pt unknown
- 2004-12-30 RS RSP-2009/0329A patent/RS50824B/sr unknown
-
2006
- 2006-06-09 ZA ZA200604748A patent/ZA200604748B/xx unknown
- 2006-06-15 NO NO20062805A patent/NO335838B1/no not_active IP Right Cessation
- 2006-06-29 US US11/478,968 patent/US7388024B2/en not_active Expired - Lifetime
-
2009
- 2009-08-03 CY CY20091100812T patent/CY1109278T1/el unknown
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