BRPI0418166A - compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes - Google Patents

compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes

Info

Publication number
BRPI0418166A
BRPI0418166A BRPI0418166-2A BRPI0418166A BRPI0418166A BR PI0418166 A BRPI0418166 A BR PI0418166A BR PI0418166 A BRPI0418166 A BR PI0418166A BR PI0418166 A BRPI0418166 A BR PI0418166A
Authority
BR
Brazil
Prior art keywords
compounds
ion channel
bicycloetheroylamine
channel ligands
ligands
Prior art date
Application number
BRPI0418166-2A
Other languages
English (en)
Inventor
Michael G Kelly
Satyanarayana Janagani
Guoxian Wu
John Kincaid
David Lonergan
Yunfeng Fang
Zhi-Liang Wei
Original Assignee
Renovis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Publication of BRPI0418166A publication Critical patent/BRPI0418166A/pt

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

COMPOSTOS DE BICICLOETEROARILAMINA COMO LIGANDOS DE CANAL DE ìON E USOS DESTES. A presente invenção refere-se a compostos de amina que têm uma fórmula representada pela seguinte: Os compostos podem ser preparados como composições farmacêuticas e podem ser empregados para a prevenção e tratamento de uma veriedade de condições em mamíferos incluindo seres humanos, incluindo por meio de exemplos não limitantes,dor, inflamação, lesão traumática e outros.
BRPI0418166-2A 2003-12-24 2004-12-23 compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes BRPI0418166A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53237103P 2003-12-24 2003-12-24
PCT/US2004/043456 WO2005066171A1 (en) 2003-12-24 2004-12-23 Bicycloheteroarylamine compounds as ion channel ligands and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0418166A true BRPI0418166A (pt) 2007-06-19

Family

ID=34748796

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418166-2A BRPI0418166A (pt) 2003-12-24 2004-12-23 compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes

Country Status (8)

Country Link
US (1) US7414131B2 (pt)
EP (1) EP1697361A1 (pt)
JP (1) JP2007517045A (pt)
AR (1) AR051156A1 (pt)
BR (1) BRPI0418166A (pt)
CA (1) CA2550717A1 (pt)
TW (1) TW200530235A (pt)
WO (1) WO2005066171A1 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312330B2 (en) * 2003-12-24 2007-12-25 Renovis, Inc. Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
US20060128710A1 (en) * 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
MX2007012335A (es) * 2005-04-11 2007-11-21 Hoffmann La Roche (3,4-dihidro-quinazolina-2-il)-indano-1-il-aminas.
MX2007013606A (es) * 2005-05-04 2007-12-10 Hoffmann La Roche (3,4-dihidro-quinazolin2-il)-(2-ariloxi-etil)-aminas que tienen una actividad en el receptor 5-ht.
KR20080070749A (ko) 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법
TWI464148B (zh) * 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
WO2007109182A2 (en) * 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
US20080004282A1 (en) * 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20080095720A1 (en) * 2006-10-18 2008-04-24 Conopco, Inc., D/B/A Unilever Skin Benefit Compositions with a Vanilloid Receptor Antagonist
CN101686680B (zh) * 2007-03-09 2015-12-09 伊沃泰克美国股份有限公司 作为p2x7调节剂的双环杂芳基化合物及其用途
WO2008130481A1 (en) * 2007-04-17 2008-10-30 Renovis, Inc. 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CA2689429C (en) * 2007-06-15 2012-08-21 Banyu Pharmaceutical Co., Ltd. Bicycloaniline derivatives
WO2009078999A1 (en) 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
BRPI0910850B1 (pt) 2008-04-21 2022-06-14 Otonomy, Inc. Composição intratimpânica compreendendo fator neurotrófico de crescimento derivado do cérebro (bdnf) para o tratamento ou prevenção da perda auditiva
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
CN102105133B (zh) 2008-07-21 2015-06-17 奥德纳米有限公司 控制释放型耳结构调节和先天性免疫系统调节组合物以及治疗耳部病症的方法
EP2318377B1 (en) 2008-07-31 2013-08-21 Genentech, Inc. Pyrimidine compounds, compositions and methods of use
CA2733533C (en) 2008-08-25 2013-12-17 Irm Llc Hedgehog pathway modulators
US8759362B2 (en) * 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
CN102711766B (zh) 2009-11-12 2014-06-04 霍夫曼-拉罗奇有限公司 N-9-取代的嘌呤化合物、组合物和使用方法
CN102712642B (zh) 2009-11-12 2015-08-12 霍夫曼-拉罗奇有限公司 N-7取代的嘌呤和吡唑并嘧啶化合物、组合物和使用方法
WO2013134518A1 (en) * 2012-03-09 2013-09-12 Amgen Inc. Sulfamide sodium channel inhibitors
JP5851663B1 (ja) 2014-05-29 2016-02-03 大鵬薬品工業株式会社 新規テトラヒドロピリドピリミジン化合物又はその塩
WO2017090719A1 (ja) * 2015-11-27 2017-06-01 大鵬薬品工業株式会社 縮環ピリミジン化合物又はその塩
KR20190024983A (ko) 2016-06-29 2019-03-08 오토노미, 인코포레이티드 트리글리세라이드 귀 제제 및 이의 용도
AU2018349376A1 (en) * 2017-10-09 2020-05-07 Ramot At Tel-Aviv University Ltd. Modulators of potassium ion and TRPV1 channels and uses thereof
AR118243A1 (es) 2019-03-07 2021-09-22 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN110256420B (zh) * 2019-05-07 2020-04-28 江西中医药大学 四氢吡啶并嘧啶衍生物及其制备方法和用途
JP2024538851A (ja) * 2021-10-08 2024-10-23 ブライズ セラピューティクス，インコーポレイテッド がん治療のための小分子

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04224580A (ja) 1990-12-25 1992-08-13 Nippon Soda Co Ltd ピリミジン誘導体、その製造方法及び農園芸用殺菌剤
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
JP4495257B2 (ja) 1997-02-19 2010-06-30 バーレツクス ラボラトリーズ インコーポレーテツド Ｎｏｓ抑制剤としてのｎ−複素環誘導体
AU1071301A (en) 1999-11-01 2001-05-14 Eli Lilly And Company Pharmaceutical compounds
ES2266258T3 (es) 2000-09-15 2007-03-01 Vertex Pharmaceuticals Incorporated Compuestos de pirazol utiles como inhibidores de proteina cinasas.
EP1345925B1 (en) 2000-12-21 2006-05-17 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ATE295362T1 (de) 2001-01-02 2005-05-15 Hoffmann La Roche Chinazolone derivate als alfa 1a/b adrenozeptor antagonisten
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
US7105667B2 (en) * 2001-05-01 2006-09-12 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
CA2469316A1 (en) 2001-12-07 2003-06-19 Vertex Pharmaceuticals, Inc. Pyrimidine-based compounds useful as gsk-3 inhibitors
US6924290B2 (en) 2002-01-23 2005-08-02 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
GB0206033D0 (en) 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy
AU2003242252A1 (en) 2002-06-07 2003-12-22 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
JP4530852B2 (ja) 2002-07-15 2010-08-25 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病治療のためのピペリジノピリミジンジペプチジルペプチダーゼ阻害剤
GB0225908D0 (en) 2002-11-06 2002-12-11 Pfizer Ltd Treatment of female sexual dysfunction
CA2520465A1 (en) 2003-03-28 2004-10-14 Scios Inc. Bi-cyclic pyrimidine inhibitors of tgf.beta.
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
JP2007524673A (ja) * 2004-01-23 2007-08-30 アムジエン・インコーポレーテツド バニロイド受容体リガンドと治療におけるその使用

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EP1697361A1 (en) 2006-09-06
JP2007517045A (ja) 2007-06-28
TW200530235A (en) 2005-09-16
CA2550717A1 (en) 2005-07-21
WO2005066171A1 (en) 2005-07-21

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